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Adaptive responses of innate lymphocytes
Nature Immunology, 2018The activating natural killer cell receptor NKG2C can specifically recognize peptides derived from the cytomegalovirus protein UL40 in the context of HLA-E. This drives the expansion of a population of adaptive NKG2C+ natural killer cells.
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B-lymphocytes, innate immunity, and autoimmunity
Clinical Immunology, 2005Having evolved to generate a huge Ag-specific repertoire and to mount T cell-dependent responses and long-term memory, the B lymphocyte is a central player in the adaptive branch of immune defense. However, accumulating evidence indicates that B-1 cells of the peritoneal cavity and marginal zone (MZ) B cells of the spleen also can play innate-like ...
Muriel, Viau, Moncef, Zouali
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Transcriptional Regulation of Innate and Adaptive Lymphocyte Lineages
Annual Review of Immunology, 2015The lymphocyte family has expanded significantly in recent years to include not only the adaptive lymphocytes (T cells, B cells) and NK cells, but also several additional innate lymphoid cell (ILC) types. ILCs lack clonally distributed antigen receptors characteristic of adaptive lymphocytes and instead respond exclusively to signaling via germline ...
Avinash Bhandoola +1 more
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iNKT Cells: Innate Lymphocytes with a Diverse Response
Critical Reviews in Immunology, 2014It is now established that natural killer T (NKT) cells can influence adaptive immune responses by producing vast amounts of cytokines. Different subsets of NKT cells with distinctive functional characteristics regarding cytokine production have been described.
Monteiro, Marta, Graca, Luis
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Transcriptional control of innate lymphocyte fate decisions
Current Opinion in Immunology, 2012It has recently emerged that innate lymphocytes are more diverse than previously appreciated. In addition to natural killer cells, various subsets of innate lymphoid cells are now being characterized. It has become apparent that the transcriptional programs underlying lineage specification and cell fate decisions of innate lymphocytes strikingly ...
Klose, Christoph S. N. +4 more
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Parallels and differences between innate and adaptive lymphocytes
Nature Immunology, 2016Lymphocytes are essential in innate and adaptive immunity. Recent insights suggest that some innate lymphocytes execute functions with adaptive characteristics, while adaptive lymphocytes can operate in ways reminiscent of innate cells. Rather than partitioning lymphocytes according to the type of effector function they execute, we propose that a ...
Sammy, Bedoui +3 more
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Autoreactivity by design: innate B and T lymphocytes
Nature Reviews Immunology, 2001Innate B and T lymphocytes are a subset of lymphocytes that express a restricted set of semi-invariant, germ-line-encoded, autoreactive antigen receptors. Although they have long been set apart from mainstream immunological thought, they now seem to represent a distinct immune-recognition strategy that targets conserved stress-induced self-structures ...
A, Bendelac, M, Bonneville, J F, Kearney
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A shared gene‐expression signature in innate‐like lymphocytes
Immunological Reviews, 2005Summary: Innate and adaptive immunities are the two major arms of the immune system, which rely on distinct cell types. These cells can be distinguished not only by the source of diversity for non‐self recognition, of germline or somatic origin, but also by their localization and the pattern and rates of response after encounter of antigenic triggers.
Tetsuya, Yamagata +2 more
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