In silico analyses suggest the cardiac ganglion of the lobster, Homarus americanus, contains a diverse array of putative innexin/innexin-like proteins, including both known and novel members of this protein family [PDF]
Gap junctions are physical channels that connect adjacent cells, permitting the flow of small molecules/ions between the cytoplasms of the coupled units.
Hull, J. Joe +2 more
core
Gap junctions: historical discoveries and new findings in the Caenorhabditis elegans nervous system
Gap junctions are evolutionarily conserved structures at close membrane contacts between two cells. In the nervous system, they mediate rapid, often bi-directional, transmission of signals through channels called innexins in invertebrates and connexins ...
Eugene Jennifer Jin +3 more
doaj +1 more source
How collective cell migration starts and stops is a fundamental question but remains poorly understood. This review discusses the distinct mechanisms in in vivo models and cancer metastasis that define the regulatory pathways and collective features governing the initiation and termination of collective cell migration.
Guangxia Miao
wiley +1 more source
A Gap Junction Protein, Inx2, Modulates Calcium Flux to Specify Border Cell Fate during Drosophila oogenesis. [PDF]
Intercellular communication mediated by gap junction (GJ) proteins is indispensable during embryogenesis, tissue regeneration and wound healing. Here we report functional analysis of a gap junction protein, Innexin 2 (Inx2), in cell type specification ...
Aresh Sahu +3 more
doaj +1 more source
FMRFamides are evolutionarily conserved neuropeptides that play critical roles in behavior, energy balance, and reproduction. Here, we show that FMRFamide signaling from the nervous system is critical for the rhythmic activation of a single cell of ...
Ukjin Choi +3 more
doaj +1 more source
Cloning and Expression of Hydra Innexin 2, a Gap Junction Protein Required for Coordinated Contraction of the Body Column [PDF]
In invertebrates gap junctions are formed by the innexin family of proteins. Remarkably, the genome of Hydra magnipapillata contains 17 innexin genes. This study focused on Hydra innexin-2 (h-Inx2) which is expressed in nerve cells and plays a role in ...
O\u27Brien, Ashley
core
The Concise Guide to PHARMACOLOGY 2025/26: Ion channels
The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander +86 more
wiley +1 more source
Innexins: Expression, Regulation, and Functions
The innexin (Inx) proteins form gap junction channels and non-junctional channels (named hemichannels) in invertebrates. These channels participate in cellular communication playing a relevant role in several physiological processes.
Juan Güiza +4 more
doaj +1 more source
The Southern King Crab (Lithodes santolla), an ecologically and commercially important species in sub‐Antarctic waters. In this study, we assembled the first gill de novo transcriptome of L. santolla to characterize gene expression related to environmental responses.
Alexandra Brante +5 more
wiley +1 more source
An Innexin-Dependent Cell Network Establishes Left-Right Neuronal Asymmetry in C. elegans [PDF]
SummaryGap junctions are widespread in immature neuronal circuits, but their functional significance is poorly understood. We show here that a transient network formed by the innexin gap-junction protein NSY-5 coordinates left-right asymmetry in the ...
VanHoven, Miri K. +4 more
core +1 more source

