Results 81 to 90 of about 1,266 (160)

Effects of Innexin knockdown with RNAi on the strength of the JON-GF connection.

, 2016
Box-whisker plots of the probability of GF spiking in response to SEP1 and SEP2. Controls are shown in gray and correspond to JO15-GAL4/+ in A and peb-GAL4 > Dcr-2 in B-H. Experimental RNAi data are shown in pink.
Jonathan M. Blagburn (442152), Jonathan P. Bacon (2600689), Adeline P. Pézier (2600692), Sami H. Jezzini (650703)   +3 more
core   +1 more source

The caenorhabditis elegans innexin INX-3 is localized to gap junctions and is essential for embryonic development [PDF]

, 2003
Innexins are the proposed structural components of gap junctions in invertebrates. Antibodies that specifically recognize the Caenorhabditis elegans innexin protein INX-3 were generated and used to examine the patterns of inx-3 gene expression and the ...
Nguyen, Rachel L, Hall, David H, Shaw, Jocelyn E, Miller, Agnes, Starich, Todd A   +4 more
core   +1 more source

Reduced insulin signaling maintains electrical transmission in a neural circuit in aging flies.

PLoS Biology, 2017
Lowered insulin/insulin-like growth factor (IGF) signaling (IIS) can extend healthy lifespan in worms, flies, and mice, but it can also have adverse effects (the "insulin paradox").
Hrvoje Augustin, Kieran McGourty, Marcus J Allen, Sirisha Kudumala Madem, Jennifer Adcott, Fiona Kerr, Chi Tung Wong, Alec Vincent, Tanja Godenschwege, Emmanuel Boucrot, Linda Partridge   +10 more
doaj   +1 more source

Atomic structure of the innexin-6 gap junction channel determined by cryo-EM

Nature Communications, 2016
Gap junctions have critical roles in maintaining homeostasis in multicellular organisms. Here the authors present cryo-EM structures of the C. elegansinnexin-6 gap junction channel, revealing high structural similarity to human connexin 26 despite a ...
Atsunori Oshima, Kazutoshi Tani, Yoshinori Fujiyoshi   +2 more
doaj   +1 more source

Structural Analysis of the Drosophila Innexin ShakB: Role of the N-Terminus in Rectifying Electrical Synapses [PDF]

, 2012
Gap junction channels mediate direct intercellular communication in all multicellular animals. They are comprised of the connexin family of proteins in vertebrates and the innexin family in prechordates.
Marks, William
core  

Innexin hemichannel activation by Microplitis bicoloratus ecSOD monopolymer reduces ROS

iScience
Summary: The extracellular superoxide dismutases (ecSODs) secreted by Microplitis bicoloratus reduce the reactive oxygen species (ROS) stimulated by the Microplitis bicoloratus bracovirus.
Jiang-Hui Meng, Yong-Biao Huang, Jin Long, Qiu-Chen Cai, Xin Qiao, Qiong-Li Zhang, Li-Dan Zhang, Xiang Yan, Rui Jing, Xing-Shan Liu, Sai-Jun Zhou, Yong-Sheng Yuan, Yin-Chen Ma, Li-Xiang Zhou, Nan-Nan Peng, Xing-Cheng Li, Cheng-Hui Cai, Hong-Mei Tang, André F. Martins, Jean X. Jiang, Kai-Jun Luo   +20 more
doaj   +1 more source

Arachidonic acid closes innexin/pannexin channels and thereby inhibits microglia cell movement to a nerve injury

, 2013
Pannexons are membrane channels formed by pannexins and are permeable to ATP. They have been implicated in various physiological and pathophysiological processes. Innexins, the invertebrate homologues of the pannexins, form innexons. Nerve injury induces
Dahl, Gerhard, Muller, Kenneth J, Gerhard Dahl, Samuels, Stuart E, Junjie Wang, Stuart E. Samuels, Lipitz, Jeffrey B, Kenneth J. Muller, Wang, Junjie, Jeffrey B. Lipitz   +9 more
core   +1 more source

On the molecular nature of large-pore channels.

, 2021
Membrane transport is a fundamental means to control basic cellular processes such as apoptosis, inflammation, and neurodegeneration and is mediated by a number of transporters, pumps, and channels.
Syrjanen, Johanna, Michalski, Kevin, Kawate, Toshimitsu, Furukawa, Hiro   +3 more
core   +1 more source

Functional implications of calcium permeability of the channel formed by pannexin 1. [PDF]

, 2006
Although human pannexins (PanX) are homologous to gap junction molecules, their physiological function in vertebrates remains poorly understood. Our results demonstrate that overexpression of PanX1 results in the formation of Ca(2+)-permeable gap ...
Ivanov, Dmitry, V, Panchin, YV, Vanden Abeele, F, Fabien Vanden Abeele, Panchin, Yuri V, Gordienko, D, Yuri V. Panchin, Baranova, AV, Skryma, R, Baranova, Ancha, V, Skryma, Roman, Gordienko, Dmitri, Gabriel Bidaux, Beck, Benjamin, Ivanov, DV, Prevarskaya, N, Ancha V. Baranova, Baranova, Ancha V, Natalia Prevarskaya, Benjamin Beck, Ivanov, Dmitry V, Panchin, Yuri, Ivanov, Dimitri, Prevarskaya, Natalia, Vanden Abeele, Fabien, Bidaux, G, Bidaux, Gabriel, Dmitry V. Ivanov, Beck, B, Panchin, Yuri, V, Roman Skryma, Dmitri Gordienko   +31 more
core   +1 more source

Study of cell interaction through innexin-2 in the formation of gap junctions in Rhynchosciara americana: a a morphological and molecular approach.

, 2017
As junções comunicantes medeiam a comunicação entre células e são fundamentais para o desenvolvimento e homeostase em organismos multicelulares. Nos invertebrados as junções são formadas por proteínas transmembrana denominadas inexinas.
Neves, Jorge Henrique
core   +1 more source