Results 101 to 110 of about 582,708 (219)
Endoplasmic Reticulum Calcium Signaling in Hippocampal Neurons
BiomoleculesThe endoplasmic reticulum (ER) is a key organelle in cellular homeostasis, regulating calcium levels and coordinating protein synthesis and folding. In neurons, the ER forms interconnected sheets and tubules that facilitate the propagation of calcium ...
Vyacheslav M. Shkryl
doaj +1 more source
Investigation of the Pathomechanism of Chronic Cough Using an In Vitro Approach
Clinical &Experimental Allergy, Volume 55, Issue 3, Page 247-249, March 2025.
Umesh Singh, Jonathan A. Bernstein
wiley +1 more source
Reciprocal control of viral infection and phosphoinositide dynamics
FEBS Letters, Volume 600, Issue 17, Page 2526-2546, September 2026.Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley +1 more source
Inositol 1,4,5-Trisphosphate Receptor Phosphorylation in Breast Cancer
Tumor Biology, 2005 The aim of this study was to establish the type(s) of inositol 1,4,5-trisphosphate receptors (IP3Rs) in T47D breast cancer cells that regulate intracellular calcium (Ca2+) and whether they interact with cyclin (Cy), an important regulator of cyclin-dependent kinases (cdk), during cell cycle progression.
Damien, Soghoian +4 more
openaire +2 more sources
Distribution of Inositol 1,4,5-Trisphosphate Receptors in Rat Osteoclasts
ACTA HISTOCHEMICA ET CYTOCHEMICA, 2008 Inositol 1,4,5-trisphosphate (IP3) receptors (IP3Rs) are Ca2+ channels that localize to intracellular Ca2+ stores such as the endoplasmic reticulum (ER). Recently, IP3Rs were found to participate in the formation of the cytoskeleton and cellular adhesions. In this study, we examined the cellular localization of type I, II, and III IP3Rs to assess their
Morikawa, Kazumasa +4 more
openaire +3 more sources
Molecular genetic characterization of ataxic movement disorders in mouse and human [PDF]
, 2009 Deletion at ITPR1 underlies a young onset autosomal recessive ataxia in mice and a late onset autosomal dominant ataxia (SCA15) in humans. Data presented show the utility of investigating spontaneous mouse mutations in understanding human disease ...
van de Leemput, J.C.H. +1 more
core
Dephosphorylation of myo-inositol 1,4,5-trisphosphate and myo-inositol 1,3,4-trisphosphate [PDF]
, 1987 We have augmented our previous studies [Storey, Shears, Kirk & Michell (1984) Nature (London) 312, 374-376] on the subcellular location and properties of Ins(1,4,5)P3 (inositol 1,4,5-trisphosphate) phosphatases in rat liver and human erythrocytes. We
Storey, DJ +6 more
core +1 more source
, 1993 The correlation between the increase of [Ca2+]i and the activation of hydrolysis of phosphoinositide-4,5-bisphosphate and formation of inositol(1,4,5)trisphosphate in neutrophils treated with Fc receptor-binding agonists is still under discussion.
DUSI, Stefano +3 more
core +1 more source
Inositol 1,4,5 trisphosphate (IP3) receptor.
Folia Pharmacologica Japonica, 2003 The intensive molecular and biochemical study of IP(3)R has made great progress in elucidating the following unique properties of IP(3)R: 1) IP(3) dependent Ca(2+) release is quantal in nature; 2) IP(3)R allosterically and dynamically changes its form; 3) IP(3)R is functional even though it is fragmented by proteases into several pieces; 4) IP(3)R ...
openaire +3 more sources
Inositol 1,4,5-trisphosphate receptor in the liver: Expression and function
World Journal of Gastroenterology, 2019 The liver is a complex organ that performs several functions to maintain homeostasis. These functions are modulated by calcium, a second messenger that regulates several intracellular events. In hepatocytes and cholangiocytes, which are the epithelial cell types in the liver, inositol 1,4,5-trisphosphate (InsP3) receptors (ITPR) are the only ...
Lemos, Fernanda de Oliveira +4 more
openaire +2 more sources