Results 121 to 130 of about 582,708 (219)
PLoS Neglected Tropical Diseases, 2020 Chagas cardiomyopathy is the most severe manifestation of human Chagas disease and represents the major cause of morbidity and mortality in Latin America.
Alfredo Mijares +3 more
doaj +1 more source
Advanced Science, Volume 13, Issue 53, 24 September 2026.NSUN2‐mediated m5C modification cooperates with ALYREF to stabilize and export IP3R3 mRNA, increasing IP3R3 expression and Ca2 + overload in chondrocytes. This signaling promotes mitochondrial dysfunction, NLRP3 inflammasome activation, and senescence, thereby accelerating osteoarthritis progression.
Guping Mao +8 more
wiley +1 more source
Functional determination of calcium-binding sites required for the activation of inositol 1,4,5-trisphosphate receptors. [PDF]
Proc Natl Acad Sci U S A, 2022 Arige V +8 more
europepmc +1 more source
Developmental and Regional Studies of the Metabolism of Inositol 1,4,5-Trisphosphate in Rat Brain [PDF]
, 1990 Coupling of CNS receptors to phosphoinositide turnover has previously been found to vary with both age and brain region. To determine whether the metabolism of the second messenger inositol 1,4,5-trisphosphate also displays such variations, activities of
Seguin, Edward B. +2 more
core +1 more source
Biological Research, 2006 Nuclear calcium appears to have an important role in the regulation of gene expression in many cells, but the mechanisms involved in controlling nuclear Ca2+ signaling are controversial and still poorly understood.
CARLOS KUSNIER +3 more
doaj
Cell Biochemistry and Function, Volume 44, Issue 9, September 2026.ABSTRACT Idiopathic pulmonary fibrosis (IPF) is a fatal interstitial lung disease of unknown cause, marked by excessive deposition of extracellular matrix (ECM) components such as collagen. This pathological accumulation results in progressive destruction of the lung architecture and ultimately leads to respiratory failure.
Yining Zhang +4 more
wiley +1 more source
IP3 receptors and Ca2+ signals in adult skeletal muscle satellite cells in situ
Biological Research, 2004 In this short article we review muscle satellite cell characteristics and our studies in adult rodent muscle satellite cells in situ. Using confocal laser scanning microscopy and immunocytochemistry, a high level of IP3 receptor (IP3R) immunostaining was
JORDI MOLGÓ +3 more
doaj
Subcellular Mechanisms of Presenilin-Mediated Enhancement of Calcium Signaling
Neurobiology of Disease, 2001 Mutations in presenilin-1 (PS1), the leading cause of early-onset, autosomal-dominant familial Alzheimer's disease (FAD), enhance calcium signaling mediated by inositol 1,4,5-trisphosphate (IP3).
Malcolm A. Leissring +3 more
doaj +1 more source
European Journal of Immunology, Volume 56, Issue 9, September 2026.(A) BMMCs are substantially more resistant to oxygen deprivation than neurons, microglia, oligodendrocytes, astrocytes, and fibroblasts. (B) Role of SHIP‐1 in primary mouse bone marrow mast cells’ hypoxia response. Under hypoxia, SHIP‐1 induces cytokine release. SHIP1 restrains hypoxia/reoxygenation‐induced cytokine secretion in BMMCs via the RAS/ RAF,
Lara Gubeljak +8 more
wiley +1 more source
Stepwise enzymatic dephosphorylation of inositol 1,4,5-trisphosphate to inositol in liver
, 1984 Many receptors for hormones, neurotransmitters and other signals cause hydrolysis of phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) and effect a rise in cytosolic Ca2+ concentration1-7.
Kirk, Christopher J. +7 more
core +1 more source