Results 111 to 120 of about 582,708 (219)

Differential coupling of G-protein-linked receptors to Ca2+mobilization through inositol(1,4,5)trisphosphate or ryanodine receptors in cerebellar granule cells in primary culture

, 1999
Rat cerebellar granule cells in primary culture possess muscarinic, metabotropic glutamatergic, histaminergic and α‐adrenergic receptors which couple to phosphoinositide‐specific phospholipase C.
McLaughlin, Mark, Downes, C.P., Del Río, E., E. Del Río, D. G. Nicholls, Mark Mclaughlin, Nicholls, D.G., C. P. Downes   +7 more
core   +1 more source

Formation and actions of calcium-mobilizing messenger, inositol 1,4,5-trisphosphate

, 1987
A variety of surface membrane receptors can activate a phospholipase C, which degrades phosphatidylinositol 4,5-bisphosphate liberating a calcium mobilizing second messenger, inositol 1,4,5-trisphosphate [(1,4,5)IP3].
J. W. Putney
core   +1 more source

Expression of Tas1 taste receptors in mammalian spermatozoa [PDF]

, 2012
Background: During their transit through the female genital tract, sperm have to recognize and discriminate numerous chemical compounds. However, our current knowledge of the molecular identity of appropriate chemosensory receptor proteins in sperm is ...
Ulrich Boehm (180339), de Angelis Martin Hrabé, Breit, A., Dorke Meyer, Andreas Breit (180329), Hrabě de Angelis, M., Widmayer Patricia, Wolfgang Meyerhof, Boekhoff Ingrid, Boehm, Ulrich, Martin Hrabé de Angelis, Meyer, Dorke, Ulrich Boehm, Dorke Meyer (180311), Sandra Huebner, Gudermann, T., Boehm, U., Borth, Heike, Borth Heike, Meyerhof, Wolfgang, Susan Marschall, Huebner Sandra, Voigt, Anja, Meyerhof, W., Hrabé de Angelis, Martin, Huebner, S., Sandra Huebner (180323), Thomas Gudermann (77426), Huebner, Sandra, Heike Borth, Borth, H., Susan Marschall (180334), Meyerhof Wolfgang, Ingrid Boekhoff, Ingrid Boekhoff (180345), Heike Borth (180317), Andreas Breit, Meyer Dorke, Boekhoff, I., Voigt Anja, Thomas Gudermann, Anja Voigt, Voigt, A., Gudermann Thomas, Breit Andreas, Boehm Ulrich, Marschall Susan, Marschall, Susan, Widmayer, Patricia, Widmayer, P., Wolfgang Meyerhof (7851), Patricia Widmayer, Martin Hrabé de Angelis (10007), Patricia Widmayer (180314), Breit, Andreas, Boekhoff, Ingrid, Gudermann, Thomas, Anja Voigt (173059), Marschall, S., Meyer, D., Meyer, D. ; Voigt, A. ; Widmayer, P. ; Borth, H. ; Huebner, S. ; Breit, A. ; Marschall, S. ; Hrabé de Angelis, M. ; Boehm, U. ; Meyerhof, W. ; Gudermann, T. ; Boekhoff, I.   +60 more
core   +1 more source

Mechanisms underlying gastric antral slow waves – a human perspective

The Journal of Physiology, EarlyView.
Dirk F. van Helden
wiley   +1 more source

MAM‐Localized MANF Counteracts Microinflammatory Stress to Attenuate Mitochondrial Dysfunction and Cataractogenesis in High Myopia

Advanced Science, Volume 13, Issue 53, 24 September 2026.
Chronic microinflammation in high myopia suppresses MANF in lens epithelial cells. MANF normally resides within MAMs and promotes ubiquitin‐mediated degradation of the ER Ca2+ pump SERCA2. MANF loss causes pathological SERCA2 accumulation, MAM hyperassembly, and disrupted ER‐to‐mitochondria Ca2+ transfer, leading to mitochondrial failure, oxidative ...
Xin Liu, Hao Li, Ching Kang, Dongling Guo, Shuyu Liu, Jiaqi Meng, Zhiqian Huang, Yu Du, Xiangjia Zhu   +8 more
wiley   +1 more source

The disease mutation A77V in Ryanodine receptor RyR2 induces changes in energy conduction pathways in the protein [PDF]

, 2011
Energetically responsive residues of the 217 amino acid N-terminal domain of the cardiac Ryanodine receptor RyR2 are identified by a simple elastic net model. These residues lie along a hydrogen bonded path through the protein.
Nazan Walpoth, Burak Erman
core  

Purine-based inhibitors of inositol-1,4,5-trisphosphate-3-kinase

, 2002
Calcium metabolism regulation may be studied by use of a novel purine-based inhibitor of inositol 1,4,5-trisphosphate 3-kinase (IP3K) developed by purine library screening (IC50= 10.2 muM). This new IP3K inhibitor 1 increased Ca2+ ion release as a result
Choi, Gildon, Gray, NS, Cox, RJ, Moon, Ho-Sang, Choi, Kwan Yong, Chung, SK, Ryu, Sung Ho, Burdett, Matthew, Gray, Nathanael S., Chung, Sung-Kee, Ryu, SH, Suh, PG, Bae, Yoe-Sik, Schultz, Peter G., Choi, G, Meijer, Laurent, Mogk, Axel, Mayo-Martin, MB, Lee, Jae Wook, Schultz, PG, Waldmann, H., Chang, Young-Tae, Eisele, F., Burdett, M, Suh, Pann-Ghill, CHANG, YOUNG TAE, Meijer, L, Deuerling, Elke, Bae, YS, Ludolph, B., Gibson, JS, Mayer, Matthias P., Moon, HS, Lee, JW, Choi, KY   +34 more
core   +1 more source

Acetylcholine- and inositol 1,4,5-trisphosphate-induced calcium mobilization in Xenopus laevis oocytes [PDF]

, 1986
Acetylcholine induces a complex electrical membrane response in Xenopus laevis oocytes. This response is mimicked, and probably mediated by injected inositol 1,4,5-trisphosphate.
Gillo, Boaz, Yoram Lass, Nadler, Etta, Yoram Oron, Boaz Gillo, Lass, Yoram, Etta Nadler, Oron, Yoram   +7 more
core   +1 more source

Investigating the Role of Inositol 1,4,5-Trisphosphate Receptors in the Pathogenesis of Alzheimer’s Disease Through Computational Modeling

Biophysica
Alzheimer’s disease (AD) is the most common form of dementia, characterized by the progressive accumulation of amyloid β (Aβ) plaques and neurofibrillary tangles of tau protein in and around neurons.
Shamima Akter, Ghanim Ullah, Aman Ullah
doaj   +1 more source

The release of calcium from the endoplasmic reticulum induced by amyloid-beta and prion peptides activates the mitochondrial apoptotic pathway

Neurobiology of Disease, 2008
In this study, we analyzed whether ER Ca2+ release, induced by amyloid-β (Aβ) and prion (PrP) peptides activates the mitochondrial-mediated apoptotic pathway.
Elisabete Ferreiro, Catarina R. Oliveira, Cláudia M.F. Pereira   +2 more
doaj   +1 more source