Results 11 to 20 of about 582,708 (219)

Inositol 1,4,5-Trisphosphate Receptors in Hypertension [PDF]

Frontiers in Physiology, 2018
Chronic hypertension remains a major cause of global mortality and morbidity. It is a complex disease that is the clinical manifestation of multiple genetic, environmental, nutritional, hormonal, and aging-related disorders.
Ali H. Eid, Ali H. Eid, Ahmed F. El-Yazbi, Ahmed F. El-Yazbi, Fouad Zouein, Abdelilah Arredouani, Allal Ouhtit, Md M. Rahman, Hatem Zayed, Gianfranco Pintus, Haissam Abou-Saleh   +10 more
doaj   +7 more sources

A Comparative Perspective on Functionally-Related, Intracellular Calcium Channels: The Insect Ryanodine and Inositol 1,4,5-Trisphosphate Receptors [PDF]

Biomolecules, 2021
Calcium (Ca2+) homeostasis is vital for insect development and metabolism, and the endoplasmic reticulum (ER) is a major intracellular reservoir for Ca2+.
Umut Toprak, Cansu Doğan, Dwayne Hegedus   +2 more
doaj   +4 more sources

Inositol 1,4,5-trisphosphate receptors in the heart

Biological Research, 2004
Inositol 1,4,5-trisphosphate (InsP3) is an established calcium-mobilizing messenger, which is well-known to activate Ca2+ signaling in many cell types. Contractile cardiomyocytes express hormone receptors that are coupled to the production of InsP3. Such
LAUREN MACKENZIE, H. LLEWELYN RODERICK, ANDREW PROVEN, STUART J CONWAY, MARTIN D BOOTMAN   +4 more
doaj   +8 more sources

Inositol Adenophostin: Convergent Synthesis of a Potent Agonist of d-myo-Inositol 1,4,5-Trisphosphate Receptors [PDF]

ACS Omega, 2020
D-myo-Inositol 1,4,5-trisphosphate receptors (IP3Rs) are Ca2+ channels activated by the intracellular messenger inositol 1,4,5-trisphosphate (IP3, 1). The glyconucleotide adenophostin A (AdA, 2) is a potent agonist of IP3Rs. A recent synthesis of D-chiro-
Xiangdong Su, Wolfgang Dohle, Stephen J. Mills, Joanna M. Watt, Ana M. Rossi, Colin W. Taylor, Barry V. L. Potter   +6 more
doaj   +3 more sources

Inositol 1,4,5-trisphosphate receptors are essential for fetal-maternal connection and embryo viability. [PDF]

PLoS Genetics, 2020
Inositol 1,4,5-trisphosphate receptors (IP3Rs) are a family of intracellular Ca2+ release channels located on the ER membrane, which in mammals consist of 3 different subtypes (IP3R1, IP3R2, and IP3R3) encoded by 3 genes, Itpr1, Itpr2, and Itpr3 ...
Feili Yang, Lei Huang, Alexandria Tso, Hong Wang, Li Cui, Lizhu Lin, Xiaohong Wang, Mingming Ren, Xi Fang, Jie Liu, Zhen Han, Ju Chen, Kunfu Ouyang   +12 more
doaj   +2 more sources

Mice lacking inositol 1,4,5-trisphosphate receptors exhibit dry eye. [PDF]

PLoS ONE, 2014
Tear secretion is important as it supplies water to the ocular surface and keeps eyes moist. Both the parasympathetic and sympathetic pathways contribute to tear secretion. Although intracellular Ca2+ elevation in the acinar cells of lacrimal glands is a
Takaaki Inaba, Chihiro Hisatsune, Yasumasa Sasaki, Yoko Ogawa, Etsuko Ebisui, Naoko Ogawa, Minoru Matsui, Tsutomu Takeuchi, Katsuhiko Mikoshiba, Kazuo Tsubota   +9 more
doaj   +2 more sources

Inositol 1,4,5‐Trisphosphate Receptors Regulate Vascular Smooth Muscle Cell Proliferation and Neointima Formation in Mice [PDF]

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Vascular smooth muscle cell (VSMC) proliferation is involved in many types of arterial diseases, including neointima hyperplasia, in which Ca2+ has been recognized as a key player. However, the physiological role of Ca2+ release via inositol 1,
Fang Huang, Fei Zhang, Lei Huang, Xiangbin Zhu, Can Huang, Na Li, Qingen Da, Yu Huang, Huihua Yang, Hong Wang, Lingyun Zhao, Qingsong Lin, Zee Chen, Junjie Xu, Jie Liu, Mingming Ren, Yan Wang, Zhen Han, Kunfu Ouyang   +18 more
doaj   +2 more sources

Intracellular calcium channels: Inositol-1,4,5-trisphosphate receptors [PDF]

European Journal of Pharmacology, 2014
The inositol-1,4,5-trisphosphate receptors (InsP3Rs) are the major intracellular Ca(2+)-release channels in cells. Activity of InsP3Rs is essential for elementary and global Ca(2+) events in the cell. There are three InsP3Rs isoforms that are present in mammalian cells. In this review we will focus primarily on InsP3R type 1.
Ilya Bezprozvanny, Peter B Stathopulos, Elena Popugaeva   +2 more
exaly   +5 more sources

Apical localization of inositol 1,4,5-trisphosphate receptors is independent of extended synaptotagmins in hepatocytes. [PDF]

PLoS ONE, 2014
Extended synaptotagmins (E-Syts) are a recently identified family of proteins that tether the endoplasmic reticulum (ER) to the plasma membrane (PM) in part by conferring regulation of cytosolic calcium (Ca2+) at these contact sites (Cell, 2013). However,
Maria Jimena Amaya, André G Oliveira, Lena K Schroeder, Edward S Allgeyer, Joerg Bewersdorf, Michael H Nathanson   +5 more
doaj   +2 more sources

Inositol 1,4,5‐Trisphosphate Receptors in Endothelial Cells Play an Essential Role in Vasodilation and Blood Pressure Regulation [PDF]

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2019
Background Endothelial NO synthase plays a central role in regulating vasodilation and blood pressure. Intracellular Ca2+ mobilization is a critical modulator of endothelial NO synthase function, and increased cytosolic Ca2+ concentration in endothelial ...
Qingsong Lin, Lingyun Zhao, Ran Jing, Christa Trexler, Hong Wang, Yali Li, Huayuan Tang, Fang Huang, Fei Zhang, Xi Fang, Jie Liu, Nan Jia, Ju Chen, Kunfu Ouyang   +13 more
doaj   +2 more sources