Tespa1 regulates T cell receptor-induced calcium signals by recruiting inositol 1,4,5-trisphosphate receptors [PDF]
Nature Communications, 2017 The thymocyte development protein Tespa1 is known to translate T cell receptor signals by affecting the calcium signalling cascade, but it is not clear how. Here the authors show that Tespa1 recruits IP3R1 to the TCR signalling complex.
Jingjing Liang +12 more
doaj +2 more sources
Correction: Author Correction: Tespa1 regulates T cell receptor-induced calcium signals by recruiting inositol 1,4,5-trisphosphate receptors [PDF]
Nature Communications, 2018 Nature Communications 8: Article number: 15732 (2017); Published: 9 June 2017; Updated: 12 March 2018 In the original version of this Article, the affiliation details for Yan Fang were incorrectly given as “ZJU-UoE Institute, Zhejiang University School ...
Jingjing Liang +12 more
doaj +2 more sources
Inositol 1,4,5-trisphosphate receptor expression in odontoblast cells [PDF]
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 1997 The cellular distribution of inositol 1,4,5-trisphosphate receptors was examined in rodent maxillary incisor teeth. In situ hybridization studies with a transmembrane probe of type I inositol 1,4,5-trisphosphate receptor indicated that this receptor/channel was highly expressed in odontoblast cells of incisor teeth.
Smutzer, Gregory +6 more
openaire +3 more sources
Inositol (1,4,5)-Trisphosphate Receptors in Invasive Breast Cancer: A New Prognostic Tool? [PDF]
International Journal of Molecular Sciences, 2022 Nicolas Jonckheere +2 more
exaly +2 more sources
Localization of inositol 1,4,5-trisphosphate receptors in the rat kidney [PDF]
Kidney International, 1998 Inositol 1,4,5-trisphosphate (IP3) receptors (IP3Rs) serve as intracellular calcium release channels involved in signal transduction of various hormones in the kidney. Molecular cloning studies have shown that there are three types of IP3R, designated type 1, type 2, and type 3.
Monkawa, Toshiaki +8 more
openaire +3 more sources
Inositol 1,4,5-Trisphosphate Receptors in Human Disease: A Comprehensive Update. [PDF]
J Clin Med, 2020 Inositol 1,4,5-trisphosphate receptors (ITPRs) are intracellular calcium release channels located on the endoplasmic reticulum of virtually every cell. Herein, we are reporting an updated systematic summary of the current knowledge on the functional role
Gambardella J +4 more
europepmc +3 more sources
Inositol 1,4,5-trisphosphate receptors and pacemaker rhythms
Journal of Molecular and Cellular Cardiology, 2012 Intracellular Ca(2+) plays an important role in the control of the heart rate through the interaction between Ca(2+) release by ryanodine receptors in the sarcoplasmic reticulum (SR) and the extrusion of Ca(2+) by the sodium-calcium exchanger which generates an inward current. A second type of SR Ca(2+) release channel, the inositol 1,4,5-trisphosphate
Ju, Yue-Kun +3 more
openaire +4 more sources
Insights Into Aggregation‐Delayed Phenotype of Dictyostelium discoideum [PDF]
Cell Biology International, Volume 50, Issue 9, September 2026.ABSTRACT Dictyostelium discoideum is a cellular model that has been widely used in cell signal research focusing on different cellular and developmental processes. The unique lifecycle of these cells—which involves switching between vegetative and development phases—makes Dictyostelium a reliable model for investigations in this field.
Sarah Abdulaziz Alamer
wiley +2 more sources
Cardiac inositol 1,4,5-trisphosphate receptors. [PDF]
Biochim Biophys Acta Mol Cell Res, 2017 Calcium is a second messenger that regulates almost all cellular functions. In cardiomyocytes, calcium plays an integral role in many functions including muscle contraction, gene expression, and cell death. Inositol 1,4,5-trisphosphate receptors (IP3Rs) are a family of calcium channels that are ubiquitously expressed in all tissues. In the heart, IP3Rs
Garcia MI, Boehning D.
europepmc +3 more sources
ER proteostasis meets mitochondrial function: contact sites as hubs of communication and therapeutic targets [PDF]
The FEBS Journal, Volume 293, Issue 18, Page 5585-5599, September 2026.Proteostasis ensures proper protein folding, modification, and degradation, while its impairment triggers ER stress. Chronic ER stress and maladaptive UPR via the CHOP–ERO1 axis remodel ERMCs, altering calcium signaling and mitochondrial metabolism.
Giorgia Maria Renna +5 more
wiley +2 more sources