Results 51 to 60 of about 70,433 (242)

Preliminary Investigation of Myo-Inositol Phosphates Produced by ASUIA279 Phytase on MCF-7 Cancer Cells

International Islamic University Malaysia Engineering Journal, 2011
Phytate or myo-inositol hexakisphosphates (IP6) is widely distributed in plants like rice brans. The production of myo-inositol phosphate intermediates has received much attention due to the remarkable potential health benefits offered by the compounds ...
N. Mohd. Yusoff, T. Nuge, N.H. Zainan, Y.Z.H-Y. Hashim, P. Jamal, Anis Shobirin Meor Hussin, Abd-Elaziem Farouk, and H.M. Salleh   +7 more
doaj   +1 more source

Inhibition of vascular calcification by inositol phosphates derivatized with ethylene glycol oligomers

Nature Communications, 2020
Cardiovascular calcification is a serious pathology for which effective pharmacological treatments are lacking. Here the authors show that an optimized oligo(ethylene glycol) derivative of inositol phosphate interferes with calcium phosphate ...
Antonia E. Schantl, Anja Verhulst, Ellen Neven, Geert J. Behets, Patrick C. D’Haese, Marc Maillard, David Mordasini, Olivier Phan, Michel Burnier, Dany Spaggiari, Laurent A. Decosterd, Mark G. MacAskill, Carlos J. Alcaide-Corral, Adriana A. S. Tavares, David E. Newby, Victoria C. Beindl, Roberto Maj, Anne Labarre, Chrismita Hegde, Bastien Castagner, Mattias E. Ivarsson, Jean-Christophe Leroux   +21 more
doaj   +1 more source

Biology-enabling inositol phosphates, phosphatidylinositol phosphates and derivatives

Natural Product Reports, 2007
This review highlights inositol polyphosphate- and phosphatidylinositol-based small molecule probes that have advanced our understanding of intracellular signalling.
Conway, Stuart J., Miller, Gavin J.
openaire   +3 more sources

Binding of inositol phosphates to arrestin [PDF]

FEBS Letters, 1991
Arrestin binds to phosphorylated rhodopsin in its light‐activated form (metarhodopsin II), blocking thereby its interaction with the G‐protein, transducin. In this study, we show that highly phosphorylated forms of inositol compete against the arrestin‐rhodopsin interaction.
Palczewski, Krzysztof, Pulvermüller, Alexander, Buczylko, Janina, Gutmann, Caroline, Hofmann, Klaus Peter   +4 more
openaire   +2 more sources

HSP90AB1‐Mediated Ubiquitin‐Proteasome Degradation of ITGBL1 Promotes Osteosarcoma Progression by Inhibiting Endoplasmic Reticulum Stress‐Induced Autophagy

Advanced Science, EarlyView.
This study delineates a novel HSP90AB1‐ITGBL1 signaling axis governing osteosarcoma. HSP90AB1 promotes K63‐linked ubiquitination and proteasomal degradation of ITGBL1. Restoring ITGBL1 induces reactive oxygen species‐dependent endoplasmic reticulum stress and pro‐death autophagy, suppressing tumor growth and metastasis.
Zhen Wang, Zixuan Guo, Chengwei Cao, Ziying Wang, Zifu Huang, Xiujuan Zhang, Yushu Zheng, Diankun She, Hao Zhu, Lingfeng Yu, Xuelin Zhao, Dongquan Xiang, Song Liao, Xin He, Xintong Ji, Chengsheng Wu, Cheng‐Xiong Xu, Meng Xu   +17 more
wiley   +1 more source

A sensitive method for the quantification of the mass of inositol phosphates using gas chromatography-mass spectrometry

Journal of Lipid Research, 1990
A sensitive method to directly measure the mass of inositol phosphates from biologic samples is described. The procedure uses ammonium sulfate gradient elution anion exchange column chromatography to isolate inositol monophosphate, bisphosphate ...
SD DaTorre, PB Corr, MH Creer
doaj   +1 more source

An Inositol 1,3,4,5,6-Pentakisphosphate 2-Kinase 1 Mutant with a 33-nt Deletion Showed Enhanced Tolerance to Salt and Drought Stress in Rice

Plants, 2020
OsIPK1 encodes inositol 1,3,4,5,6-pentakisphosphate 2-kinase, which catalyzes the conversion of myo-inositol-1,3,4,5,6-pentakisphosphate to myo-inositol-1,2,3,4,5,6-hexakisphosphate (IP6) in rice.
Meng Jiang, Yanhua Liu, Ruiqing Li, Shan Li, Yuanyuan Tan, Jianzhong Huang, Qingyao Shu   +6 more
doaj   +1 more source

Mitophagy and Ubiquitination Coordinate Context‐Specific Mitochondrial Quality Control and EMT/MET Plasticity to Drive Cancer Cell Invasion

Advanced Science, EarlyView.
Metastatic invasion emerges when tumor‐intrinsic programs and microenvironmental forces converge on mitochondrial quality control. A context‐stratified framework links mtROS, mtDNA integrity, mechanics and nutrient/oxygen cues to fission–fusion remodeling, mtUPR and mitophagy.
Bin‐Hsu Mao, Bo‐Kai Su, Ying‐Jan Wang, Ting‐Yuan Tu   +3 more
wiley   +1 more source

Di‐myo‐inositol‐1, 1′‐phosphate: A new inositol phosphate isolated from Pyrococcus woesei

FEBS Letters, 1992
A new inositol derivative could be isolated from the Archaeum Pyrococcus woesei and identified as di‐myo‐inositol‐1,1′‐phosphate by 1H, 31P NMR spectroscopy, mass spectrometry and thin layer chromatograpy. In P. woesel, this inositol phosphate represents the dominant counterion of K+ which ranges from 500 to 600 mM. The role of the potassium salt of di‐
Scholz, Stefan, Sonnenbichler, Johann, Schäfer, Wolfram, Hensel, Reinhard   +3 more
openaire   +2 more sources

Polydopamine‐Encapsulated Probiotics Restore Gut Homeostasis and Reinstate Macrophage Efferocytosis in Systemic Lupus Erythematosus

Advanced Science, EarlyView.
Polydopamine‐encapsulated probiotics restore gut homeostasis and reinstate macrophage efferocytosis, thereby reestablishing immune tolerance and mitigating systemic autoimmunity, highlighting a bioengineered microbiota‐based therapeutic strategy for SLE.
Ruimiao Wu, Mei Liu, Changxing Gao, Cheng Zhao, Feijie Zhao, Shuqing Dong, Bo Zhang, Qianmei Liu, Wenqian Zhang, Ming Zhao, Qianjin Lu   +10 more
wiley   +1 more source