Results 51 to 60 of about 761,638 (295)

Structural features of human inositol phosphate multikinase rationalize its inositol phosphate kinase and phosphoinositide 3-kinase activities

Journal of Biological Chemistry, 2017
Human inositol phosphate multikinase (HsIPMK) critically contributes to intracellular signaling through its inositol-1,4,5-trisphosphate (Ins(1,4,5)P3) 3-kinase and phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) 3-kinase activities. This catalytic
Huanchen Wang, S. Shears
semanticscholar   +1 more source

Two bifunctional inositol pyrophosphate kinases/phosphatases control plant phosphate homeostasis

bioRxiv, 2018
Many eukaryotic proteins regulating phosphate (Pi) homeostasis contain SPX domains. We have previously shown that these domains act as cellular receptors for inositol pyrophosphate (PP-InsP) signaling molecules, suggesting that PP-InsPs may regulate Pi ...
Jinsheng Zhu, K. Lau, Robert K. Harmel, R. Puschmann, Larissa Broger, A. Dutta, H. Jessen, L. Hothorn, D. Fiedler, M. Hothorn   +9 more
semanticscholar   +1 more source

Tipping the scales:Lessons from simple model systems on inositol imbalance in neurological disorders [PDF]

, 2017
Inositol and inositol-containing compounds have signalling and regulatory roles in many cellular processes, suggesting that inositol imbalance may lead to wide-ranging changes in cellular functions.
Abe, Adley, Alberdi, Alers, Alzheimer’s Disease International, Anna D. Frej, Bachhawat, Belmaker, Berridge, Brickner, Buckmaster, Bélanger, Calker, Cataldi, Chang, Chang, Chang, Chang, Chang, Chiu, Cho, Clark, Clements, Cremona, Criollo, Croze, Culbertson, Das, Davanzo, Dean-Johnson, Deranieh, Deranieh, Deranieh, Di Daniel, Drion, Eickholt, Fajutrao, Felberbaum, Fenili, Ferruz, Fischbach, Fischer, Frej, Fu, Ghavami, Grant P. Otto, Greenberg, Griffith, Hartman, Hasegawa, Ho, Hoyer, Irvine, Jiang, Ju, Ju, Kaddurah-Daouk, Kamada, Keith, Kennedy, King, Kirshenbaum, Klopfenstein, Kollros, Konarzewska, Kosta, Kotaria, Kurnasov, Kwan, Lester, Lhuillier, Loewus, Looney, Lopes, Lystad, MacGregor, Macias, Majumder, Martin, Masaki, McKnight, McLaurin, McMahon, Meng, Mizushima, Mohammadpour, Murray, Nonaka, Nozadze, Ohnishi, Otto, O’Donnell, Parthasarathy, Pascente, Pattni, Pereira, Prieto, Puls, Qing, Randise-Hinchliff, Robin S.B. Williams, Sarkar, Saudek, Schewe, Schiebler, Sha, Shaldubina, Shaltiel, Shetty, Shi, Shimon, Silverstone, Singh, Solomonia, Solomonia, Solomonia, Steger, Stransky, Teo, Terbach, Toker, Trushina, Vaden, van Vliet, Vanhaesebroeck, Viard, Vogel, Wang, Warsh, Watanabe, Waugh, Wellard, Whiting, Williams, Williams, Wong, Wu, Wu, Xu, Yamagami, Zeng   +140 more
core   +1 more source

Inositol monophosphate phosphatase genes of Mycobacterium tuberculosis

BMC Microbiology, 2010
Background Mycobacteria use inositol in phosphatidylinositol, for anchoring lipoarabinomannan (LAM), lipomannan (LM) and phosphatidylinosotol mannosides (PIMs) in the cell envelope, and for the production of mycothiol, which maintains the redox balance ...
Parish Tanya, Av-Gay Yossef, Dinadayala Premkumar, Wheeler Paul R, Movahedzadeh Farahnaz, Daffé Mamadou, Stoker Neil G   +6 more
doaj   +1 more source

Comparative Genomics of Pneumocystis Species Suggests the Absence of Genes for myo-Inositol Synthesis and Reliance on Inositol Transport and Metabolism

mBio, 2014
In the context of deciphering the metabolic strategies of the obligate pathogenic fungi in the genus Pneumocystis, the genomes of three species (P. carinii, P. murina, and P.
Aleksey Porollo, Thomas M. Sesterhenn, Margaret S. Collins, Jeffrey A. Welge, Melanie T. Cushion   +4 more
doaj   +1 more source

Effect of Fiber Fermentation and Protein Digestion Kinetics on Mineral Digestion in Pigs

Animals, 2022
Nutrient kinetic data and the timing of nutrient release along the gastrointestinal tract (GIT), are not yet widely used in current feed formulations for pigs and poultry.
Charlotte M. E. Heyer, Neil W. Jaworski, Greg I. Page, Ruurd T. Zijlstra   +3 more
doaj   +1 more source

Generation of inositol polyphosphates through a phospholipase C-independent pathway involving carbohydrate and sphingolipid metabolism in Trypanosoma cruzi

mBio
Inositol phosphates are involved in a myriad of biological roles and activities such as Ca2+ signaling, phosphate homeostasis, energy metabolism, and disease pathogenicity.
Mayara S. Bertolini, Sabrina E. Cline, Miguel A. Chiurillo, Brian S. Mantilla, Aharon Eidex, Logan P. Crowe, Danye Qiu, Henning J. Jessen, Adolfo Saiardi, Roberto Docampo   +9 more
doaj   +1 more source

Wheat inositol pyrophosphate kinase TaVIH2-3B modulates cell-wall composition and drought tolerance in Arabidopsis

BMC Biology, 2021
Background Inositol pyrophosphates (PP-InsPs) are high-energy derivatives of inositol, involved in different signalling and regulatory responses of eukaryotic cells.
Anuj Shukla, Mandeep Kaur, Swati Kanwar, Gazaldeep Kaur, Shivani Sharma, Shubhra Ganguli, Vandana Kumari, Koushik Mazumder, Pratima Pandey, Hatem Rouached, Vikas Rishi, Rashna Bhandari, Ajay Kumar Pandey   +12 more
doaj   +1 more source

Overexpression of MdMIPS1 enhances drought tolerance and water-use efficiency in apple

Journal of Integrative Agriculture, 2022
Myo-inositol and its derivatives play important roles in the tolerance of higher plants to abiotic stresses, and myo-inositol-1-phosphate synthase (MIPS) is the rate-limiting enzyme in myo-inositol biosynthesis. In this study, we found that increased myo-
Ling-yu HU, Hong YUE, Jing-yun ZHANG, Yang-tian-su LI, Xiao-qing GONG, Kun ZHOU, Feng-wang MA   +6 more
doaj   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source