Biomolecules, 2023 Multiple inositol polyphosphate phosphatase (MINPP1) is an enigmatic enzyme that is responsible for the metabolism of inositol hexakisphosphate (InsP6) and inositol 1,3,4,5,6 pentakisphosphate (Ins(1,3,4,5,6)P5 in mammalian cells, despite being ...
Jia Yu +6 more
doaj +6 more sources
Untangling Inositol (Pyro)Phosphate Biology Through Emerging Technologies [PDF]
Advanced ScienceInositol phosphates (InsPs) and inositol pyrophosphates (PP‐InsPs) constitute a remarkably diverse yet evolutionarily conserved signaling network generated through combinatorial phosphorylation of myo‐inositol.
Adolfo Saiardi +5 more
doaj +3 more sources
Crosstalk Between Ras and Inositol Phosphate Signaling Revealed by Lithium Action on Inositol Monophosphatase in Schizophyllum Commune [PDF]
Advances in Biological Regulation, 2019 Mushroom forming basidiomycete Schizophyllum commune has been used as a tractable model organism to study fungal sexual development. Ras signaling activation via G-protein-coupled receptors (GPCRs) has been postulated to play a significant role in the ...
Katrin Krause +2 more
exaly +3 more sources
Cellular adaptations of fission yeast to inositol starvation [PDF]
mBioInositol is an essential nutrient and a precursor of phosphorylated metabolites that play important roles in cell physiology. Here we characterize the impact of intracellular inositol deficiency, taking advantage of fission yeast Schizosaccharomyces ...
Ana M. Sanchez +6 more
doaj +2 more sources
The Expanding Landscape of Inositol Phosphate Signaling Network in Land Plants [PDF]
FEBS LettersThe emergence of land plants from aquatic habitat over half a billion years ago marked a pivotal moment in Earth's history, profoundly altering both soil composition and atmospheric chemistry. This remarkable evolutionary transition was accompanied by the establishment of multiple signaling pathways that facilitated plant ...
Debabrata Laha, Ranjana Yadav
exaly +4 more sources
Inositol Signaling in the Basidiomycete Fungus Schizophyllum commune [PDF]
Journal of Fungi, 2021 Intracellular signaling is conserved in eukaryotes to allow for response to extracellular signals and to regulate development and cellular functions. In fungi, inositol phosphate signaling has been shown to be involved in growth, sexual reproduction, and
Reyna Murry +6 more
doaj +2 more sources
The Role of Inositol Hexakisphosphate Kinase in the Central Nervous System
Biomolecules, 2023 Inositol is a unique biological small molecule that can be phosphorylated or even further pyrophosphorylated on each of its six hydroxyl groups. These numerous phosphorylation states of inositol along with the kinases and phosphatases that interconvert ...
Tyler Heitmann, James C. Barrow
doaj +2 more sources
Role of Inositols and Inositol Phosphates in Energy Metabolism
Molecules, 2020 Recently, inositols, especially myo-inositol and inositol hexakisphosphate, also known as phytic acid or IP6, with their biological activities received much attention for their role in multiple health beneficial effects.
Saimai Chatree +4 more
doaj +3 more sources
A Hybrid Experimental and in silico Platform for ITPK1 Chemical Probe Discovery [PDF]
SLAS DiscoveryInositol-tetrakisphosphate 1-kinase (ITPK1) is a pivotal enzyme in the inositol phosphate signaling pathway that functions to maintain the balance of inositol phosphate (IP) species.
Adam Yasgar +21 more
doaj +2 more sources
Metabolic hubs under attack: Effector-mediated manipulation of plant inositol phosphate signaling [PDF]
PLoS PathogensElena Roitsch +3 more
doaj +3 more sources