Results 161 to 170 of about 1,340,779 (272)

A New Case of Lethal Congenital Contracture Syndrome Type 3 With Hyperinsulinism and Optic Atrophy

Clinical Genetics, Volume 110, Issue 6, Page 736-741, December 2026.
PIP5K1C‐related lethal congenital contracture syndrome with hyperinsulinism and optic atrophy. ABSTRACT Lethal congenital contracture syndrome 3 (LCCS3, MIM #611369) is a rare autosomal recessive neuromuscular disorder caused by biallelic loss‐of‐function (LOF) variants in PIP5K1C, reported in only two families to date.
Tameemi Abdalla Moady, Hadar Hulin Ma'ayan, Michal Cohen, Karin Weiss   +3 more
wiley   +1 more source

Genome wide identification and analysis of inositol tetrakisphosphate kinase (ITPK) gene family in Triticum aestivum L. [PDF]

PLoS One
Umar F, Maqbool R, Khan MA, Sadia B.
europepmc   +1 more source

Stepwise evolution of the developmental and symbiotic functions of DELLA in land plants

New Phytologist, Volume 252, Issue 5, Page 1702-1710, December 2026.
Proposed model for the stepwise evolution of DELLA functions in the green lineage.
Katharina Melkonian, Tifenn Pellen, Katinka Bünger, Océane Thiercelin, Aurélie Le Ru, Mélanie K. Rich, Matheus E. Bianconi, Jean Keller, Maxime Bonhomme, Pierre‐Marc Delaux   +9 more
wiley   +1 more source

Inositol Metabolism Modulates Inflammatory Injury in Acute Pancreatitis via the ISYNA1-NETs Axis. [PDF]

J Inflamm Res
Han F, Liu X, Fan Y, Chen L, Shi X, Wang Y, Xiao W, Lu G, Wu K, Xia T, Zhuang J, Sun R.   +11 more
europepmc   +1 more source

Integration of Chemical Probes and Degradomics Reveals That Cathepsin B Functions Primarily as a Dipeptidyl Carboxypeptidase in Macrophages

ChemMedChem, Volume 21, Issue 21, 12 November 2026.
An integrated chemical biology and degradomics approach reveals the proteolytic landscape of cathepsin B in mouse macrophages. Z‐RK‐AOMK perturbs the cysteine cathepsin network and reveals that cathepsin B predominantly exhibits dipeptidyl carboxypeptidase activity in cells.
Kai‐Qi Yek, Francesca L. Apolloni, Bangyan Xu, Nghi H. Nguyen, Alexander R. Ziegler, Nichollas E. Scott, Brad E. Sleebs, Laura E. Edgington‐Mitchell   +7 more
wiley   +1 more source

A Multidimensional Engineering Strategy Reprograms Microglia via Targeted and Sustained‐Release Extracellular Vesicles for Spinal Cord Injury Repair

Advanced Science, Volume 13, Issue 61, 3 November 2026.
A multifunctional EV‐based nanoplatform (Ang‐TEVs@Gel) was engineered via preconditioning, surface targeting, and ROS‐responsive hydrogel encapsulation to reprogram microglia. This system restored autophagy via miR‐664a‐3p/PIK3CA axis, cleared myelin debris, resolved neuroinflammation, and promoted axon remyelination, ultimately achieving robust motor ...
Wu Xiong, Minhao Liu, Mingming Zheng, Jizhou Jia, Ziyan Zhu, Guang Kong, Jie Liu, Juan Wang, Wenbo Li, Qingyuan Wang, Qian Zhu, Peiran Chan, Tao Qin, Jiayang Wu, Yongjie Zhang, Chunming Tang, Cong Li, Jin Fan   +17 more
wiley   +1 more source

The phosphate exporter XPR1 promotes gasdermin D-independent mature IL-1β secretion. [PDF]

J Biol Chem
Remy N, Six C, Tury S, Van Schaftingen E, Battini JL, Lucas S, Coulie PG, Gomard T.   +7 more
europepmc   +1 more source

A Protocol for Lab‐Scale Production of 13C‐Labeled Yeast Extract as Internal Standard for Metabolomics and Quantification of Intracellular Metabolites

Current Protocols, Volume 6, Issue 11, November 2026.
Abstract Metabolomics enables the profiling of small‐molecule metabolites, thereby capturing the biochemical state of a living organism at a given moment and making it possible to monitor the organism's cellular responses to stimuli. This technique has become a powerful tool in pharmaceutical research, the food industry, and microbial research ...
Miriam Cammaert, Rosalie Wouters, Jitske van Ede, Erik de Hulster, Christiaan Mooiman, Patricia van Dam, Martin Pabst, Walter van Gulik, Pascale Daran‐Lapujade   +8 more
wiley   +1 more source

Sulfur in dialogue with phosphorus, nitrogen, and iron: regulatory networks in plant nutrient homeostasis. [PDF]

J Exp Bot
Haque AM, Takahashi H, Rouached H.
europepmc   +1 more source

Plant‐Derived Probiotics From Fermented Foods: Current Evidence on Antiviral Mechanisms and Gut–Lung Axis Modulation

Food Frontiers, Volume 7, Issue 6, November 2026.
Plant‐derived probiotics from fermented foods exert anti‐respiratory virus effects via immune regulation, antiviral metabolites, and gut–lung axis, highlighting their advantages, key technologies, and application prospects. ABSTRACT Respiratory viral infections represent a major global public health threat, causing widespread morbidity, mortality, and ...
Yinghao Xing, Yaoyuan Hu, Yingying Ma, Peng Yao, Jingjing Jiang, Jiao Guo, Shuangmei Liu   +6 more
wiley   +1 more source