Results 51 to 60 of about 30,119 (260)

Analysis of inositol phosphate metabolism by capillary electrophoresis electrospray ionization mass spectrometry

Nature Communications, 2020
Myo-Inositol phosphates (InsPs) and pyrophosphates (PP-InsPs) are important second messengers but their analysis remains challenging. Here, the authors develop a capillary electrophoresis-mass spectrometry method for the identification and quantitation ...
Danye Qiu, Miranda S. Wilson, Verena B. Eisenbeis, Robert K. Harmel, Esther Riemer, Thomas M. Haas, Christopher Wittwer, Nikolaus Jork, Chunfang Gu, Stephen B. Shears, Gabriel Schaaf, Bernd Kammerer, Dorothea Fiedler, Adolfo Saiardi, Henning J. Jessen   +14 more
doaj   +1 more source

Elucidation of Inverse Agonist Activity of Bilastine

Pharmaceutics, 2020
H1-antihistamines antagonize histamine and prevent it from binding to the histamine H1 receptor (H1R). Some of them also act as inverse agonists, which are more potent than pure antagonists because they suppress the constitutive H1R activity.
Hiroyuki Mizuguchi, Tomoharu Wakugawa, Hisato Sadakata, Seiichiro Kamimura, Mai Takemoto, Tomomi Nakagawa, Masami Yabumoto, Yoshiaki Kitamura, Noriaki Takeda, Hiroyuki Fukui   +9 more
doaj   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source

Activation of phospholipase C beta 2 by the alpha and beta gamma subunits of trimeric GTP-binding protein [PDF]

, 1993
Cotransfection assays were used to show that the members of the GTP-binding protein Gq class of alpha subunits could activate phospholipase C (PLC) beta 2.
Katz, Arieh, Simon, Melvin I., Wu, Dianqing   +2 more
core  

Organic phosphorus in the terrestrial environment: a perspective on the state of the art and future priorities [PDF]

, 2017
Background The dynamics of phosphorus (P) in the environment is important for regulating nutrient cycles in natural and managed ecosystems and an integral part in assessing biological resilience against environmental change.
Almås, R.,, Audette, Y.,, Bertrand, I.,, Beyhaut, E.,, Blackwell, M. S.A.,, Boitt, G.,, Bol, R.,, Bradshaw, N.,, Brearley, C. A.,, Bruulsema, T. W.,, Cabugao, K. G.,, Celi, L.,, Ciais, P,, Condron, L. M.,, Cotner, J. B.,, Cozzolino, V.,, Darch, T.,, de Almeida, S. S.,, Dodd, R. J.,, Dunfield, K.,, Duran, P. C.,, Engl, C.,, Feng, Carl G.,, Fraser, J. T.,, Frazão, João,, Gama-Rodrigues, A. C.,, Garland, G.,, George, T. S.,, Giesler, R,, Giles, C. D.,, Goll, Daniel S,, González Jiménez, J. L.,, Graca, J.,, Granger, S. J.,, Hallama, M.,, Harrison, A. F.,, Haygarth, P. M.,, Heuck, C.,, Hou, E. Q.,, Jaisi, D.,, Johnes, P. J.,, Kaiser, K F,, Kjær, H. A.,, Klumpp, E.,, Krueger, Robert J,, Lamb, A. L.,, Lang, Fredrick F.,, Lumsdon, D. G.,, Lund University., Lund University., Lund University., Macintosh, K. A.,, Mackay, E. B.,, McGrath, J,, McIntyre, D C,, McLaren, T.,, Menezes, Ana Maria B.,, Menezes-Blackburn, D.,, Mezeli, M. M.,, Missong, A.,, Mooshammer, M.,, Mora, M. L.,, Mészáros, E.,, Neal, A. L.,, Negrón, C. P.,, Nelson, L. A.,, Pfahler, V.,, Plassard, C,, Poblete-Grant, P.,, Randall, M.,, Richardson, A. E.,, Rosling, A.,, Seguel, A.,, Seth, K.,, Shand, C. A.,, Smith, A. C.,, Smits, M. M.,, Sobarzo, J. A.,, Spohn, M.,, Stutter, M. I.,, Tamburini, F.,, Tawaraya, K.,, Tibbett, M.,, Voroney, P.,, Wallander, H.,, Wang, L.,, Wasaki, J.,, Wearing, C.,, Zhang, H.,   +88 more
core   +12 more sources

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source

Magnetic resonance spectroscopy in migraine: what have we learned so far? [PDF]

, 2012
Objective: To summarize and evaluate proton (H-1) and phosphorus (P-31) magnetic resonance spectroscopy (MRS) findings in migraine. Methods: A thorough review of H-1 and/or P-31-MRS studies in any form of migraine published up to September 2011 ...
Achten, Eric, Paemeleire, Koen, Reyngoudt, Harmen   +2 more
core   +2 more sources

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Group-specific cellular metabolism in Medulloblastoma

Journal of Translational Medicine, 2023
Background Cancer metabolism influences multiple aspects of tumorigenesis and causes diversity across malignancies. Although comprehensive research has extended our knowledge of molecular subgroups in medulloblastoma (MB), discrete analysis of metabolic ...
Viktoria L. E. Funke, Carolin Walter, Viktoria Melcher, Lanying Wei, Sarah Sandmann, Marc Hotfilder, Julian Varghese, Natalie Jäger, Marcel Kool, David T. W. Jones, Stefan M. Pfister, Till Milde, Martin Mynarek, Stefan Rutkowski, Jochen Seggewiss, Daniela Jeising, Flavia W. de Faria, Thorsten Marquardt, Thomas K. Albert, Ulrich Schüller, Kornelius Kerl   +20 more
doaj   +1 more source