Results 91 to 100 of about 98,783 (245)

Proteome Analysis of Corynebacterium diphtheriae–Macrophage Interaction

PROTEOMICS, EarlyView.
ABSTRACT Contact of Corynebacterium diphtheriae with macrophages induces adaptations on both bacterial and cellular sides. The study presented here was aiming to shed light on the simultaneous intracellular adaptation of the bacteria and changes in the proteome of the phagocytes in response to the internalization of C. diphtheriae.
Luca Musella, Jens Möller, Christopher Lischer, Julio Vera‐Gonzalez, Jörg Hofmann, Lisa Ott, Andreas Burkovski   +6 more
wiley   +1 more source

Inositol Pyrophosphates Inhibit Synaptotagmin-Dependent Exocytosis [PDF]

Biophysical Journal, 2014
Inositol pyrophosphates such as IP7 (5-diphosphoinositol pentakisphosphate) are highly energetic inositol metabolites containing pyrophosphate bonds. While IP7 are known to regulate various biological events like metabolism, the molecular site of IP7 action in vesicle trafficking remains elusive.
Lee, TS Lee, Tae Sun, Lee, JY Lee, Joo-Young, Yang, Y Yang, Yoosoo, Lee, S Lee, Seulgi, Kim, YR Kim, Young-ran, Kong, B Kong, Byoungjae, Jho, YS Jho, Yong Seok, Kweon, DH Kweon, Dae-Hyuk, Shin, YK Shin, Yeon-Kyun, Yoon, TY Yoon, Tae-Young, Kim, S Kim, Seyun   +10 more
openaire   +1 more source

Identification and structural characterisation of a partially arabinosylated lipoarabinomannan variant isolated from a Corynebacterium glutamicum ubiAmutant [PDF]

, 2007
Arabinan polysaccharide side-chains are present in both Mycobacterium tuberculosis and Corynebacterium glutamicum in the heteropolysaccharide arabinogalactan (AG), and in M. tuberculosis in the lipoglycan, lipoarabinomannan (LAM).
Alderwick, Luke J., Besra, Gurdyal S, Dell, Anne, Eggeling, Lothar, Gilleron, Martine, Giordano, Assunta, Hitchen, Paul, Krumbach, Karin, Mishra, Arun K., Morris, Howard R., Nigou, Jerome, Tatituri, Raju Venkata Veera   +11 more
core  

Cigarette Smoke (CS) and Nicotine Delay Neutrophil Spontaneous Death via Suppressing Production of Diphosphoinositol Pentakisphosphate [PDF]

, 2014
Diphosphoinositol pentakisphosphate (InsP7), a higher inositol phosphate containing energetic pyrophosphate bonds, is beginning to emerge as a key cellular signaling molecule.
Bajrami, Besnik, Cao, Shannan, Kwak, Hyunjeong, Li, Hongmei, Liu, Peng, Luo, Hongbo, Xu, Yuanfu, Ye, Keqiang, Zhou, Jiaxi, Zhou, Yuan, Zhu, Haiyan   +10 more
core   +1 more source

Engineering Cyanobacteria for High‐Yield Photosynthetic Isoprene Production With Long‐Term Phenotypic Stability

Plant Biotechnology Journal, EarlyView.
Center: Cyanobacterial isoprene production from CO2 and sunlight. Top: CRISPR‐editing for generation of markerless production strains. Top right: Long‐term production assay for strain stability assessment. Bottom right: Engineering of MEP pathway and surrounding metabolism for bottleneck idenfication. Bottom left: Relief of bottleneck by overproduction
Kim N. Janssen, Paul Bolay, Adrian Tüllinghoff, Jörg Toepel, Daniel Spindler, Bruno Bühler, Pia Lindberg   +6 more
wiley   +1 more source

IP₇-SPX Domain Interaction Controls Fungal Virulence by Stabilizing Phosphate Signaling Machinery

mBio, 2020
In the human-pathogenic fungus Cryptococcus neoformans, the inositol polyphosphate signaling pathway is critical for virulence. We recently demonstrated the key role of the inositol pyrophosphate IP7 (isomer 5-PP-IP5) in driving fungal virulence; however,
Desmarini Desmarini, Sophie Lev, David Furkert, Ben Crossett, Adolfo Saiardi, Keren Kaufman-Francis, Cecilia Li, Tania C. Sorrell, Lorna Wilkinson-White, Jacqueline Matthews, Dorothea Fiedler, Julianne Teresa Djordjevic   +11 more
doaj   +1 more source

Using organic phosphorus to sustain pasture productivity: A perspective [PDF]

, 2013
Organic phosphorus (P) in grazed pastures/grasslands could sustain production systems that historically relied on inorganic P fertiliser. Interactions between inorganic P, plants and soils have been studied extensively.
Condron, Leo M., Haygarth, P. M., Heaven, M. W., McDowell, Richard, Nash, D. M., Richardson, A. E., Turner, B. L., Watkins, M.   +7 more
core   +1 more source

Plant Lipid Droplets and Derived Lipidic Nano‐Assemblies: Structure, Biogenesis and Pharmaceutical Applications

Plant Biotechnology Journal, EarlyView.
ABSTRACT Lipid droplets (LDs) serve as the primary storage site for neutral lipids in plant cells, with growing evidence supporting many additional biological roles, such as in lipid homeostasis, signalling, trafficking, inflammatory responses and inter‐organelle communication.
Abdulsamie Hanano, Amal Yousfan, Denis J. Murphy   +2 more
wiley   +1 more source

Identification of a major IP5 kinase in Cryptococcus neoformans confirms that PP-IP5/IP7, not IP6, is essential for virulence [PDF]

, 2016
Fungal inositol polyphosphate (IP) kinases catalyse phosphorylation of IP3 to inositol pyrophosphate, PP-IP5/IP7, which is essential for virulence of Cryptococcus neoformans.
Desmarini, D, Djordjevic, JT, Lev, S, Li, C, Saiardi, A, Sorrell, TC   +5 more
core   +2 more sources

The Contribution of Cholesterol and Squalene Synthase in Cancer: Molecular Mechanisms, Lipid Rafts and Therapeutic Approaches

Medicinal Research Reviews, Volume 46, Issue 2, Page 352-381, March 2026.
ABSTRACT A plethora of cellular signaling pathways are dysregulated in cancer cells, promoting carcinogenesis and migration. Cholesterol has recently been linked to cancer by several subcellular mechanisms, especially by its involvement in the formation of lipid rafts, which promote oncogenic signaling and cancer cell invasion. Squalene synthase (SQS),
Danai Mavridi, Theodora Katavati, Angeliki P. Kourounakis   +2 more
wiley   +1 more source