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Biosynthesis and possible functions of inositol pyrophosphates in plants [PDF]
Frontiers in Plant Science, 2015 Inositol phosphates (InsPs) are intricately tied to lipid signaling, as at least one portion of the inositol phosphate signaling pool is derived from hydrolysis of the lipid precursor, phosphatidyl inositol (4,5) bisphosphate. The focus of this review is
Glenda Gillaspy, Imara Y Perera
exaly +9 more sources
Inositol pyrophosphates activate the vacuolar transport chaperone complex in yeast by disrupting a homotypic SPX domain interaction [PDF]
Nature Communications, 2023 Many proteins involved in eukaryotic phosphate homeostasis are regulated by SPX domains. In yeast, the vacuolar transporter chaperone (VTC) complex contains two such domains, but mechanistic details of its regulation are not well understood.
Joka Pipercevic +10 more
doaj +5 more sources
Inositol Pyrophosphates: Signaling Molecules with Pleiotropic Actions in Mammals [PDF]
Molecules, 2020 Inositol pyrophosphates (PP-IPs) such as 5-diphosphoinositol pentakisphosphate (5-IP7) are inositol metabolites containing high-energy phosphoanhydride bonds.
Seulgi Lee +3 more
doaj +6 more sources
eLife, 2023 Eukaryotic cells control inorganic phosphate to balance its role as essential macronutrient with its negative bioenergetic impact on reactions liberating phosphate.
Valentin Chabert +7 more
doaj +2 more sources
Analysis of Dictyostelium discoideum inositol pyrophosphate metabolism by gel electrophoresis. [PDF]
PLoS ONE, 2014 The social amoeba Dictyostelium discoideum was instrumental in the discovery and early characterization of inositol pyrophosphates, a class of molecules possessing highly-energetic pyrophosphate bonds.
Francesca Pisani +5 more
doaj +3 more sources
mBio, 2022 Inositol pyrophosphates (IPPs) are signaling molecules that regulate cellular phosphate homeostasis in diverse eukaryal taxa. In fission yeast, mutations that increase 1,5-IP8 derepress the PHO regulon while mutations that ablate IP8 synthesis are PHO ...
Bradley Benjamin +5 more
doaj +2 more sources
The Vip1 inositol polyphosphate kinase family regulates polarized growth and modulates the microtubule cytoskeleton in fungi. [PDF]
PLoS Genetics, 2014 Microtubules (MTs) are pivotal for numerous eukaryotic processes ranging from cellular morphogenesis, chromosome segregation to intracellular transport. Execution of these tasks requires intricate regulation of MT dynamics.
Jennifer Pöhlmann +11 more
doaj +1 more source
Nature Communications, 2022 Inositol pyrophosphates (PP-IPs) regulate immunity and phosphate homeostasis. Here, the authors’ structural dissection of an Arabidopsis thaliana PP-IP phosphatase reveals that substrates drive their own hydrolysis and identifies a highly elusive ...
Huanchen Wang +7 more
doaj +1 more source
Metabolic Consequences of Polyphosphate Synthesis and Imminent Phosphate Limitation
mBio, 2023 Cells stabilize intracellular inorganic phosphate (Pi) to compromise between large biosynthetic needs and detrimental bioenergetic effects of Pi.
Geun-Don Kim +3 more
doaj +1 more source
Regulation of plant biotic interactions and abiotic stress responses by inositol polyphosphates
Frontiers in Plant Science, 2022 Inositol pyrophosphates (PP-InsPs), derivatives of inositol hexakisphosphate (phytic acid, InsP6) or lower inositol polyphosphates, are energy-rich signaling molecules that have critical regulatory functions in eukaryotes. In plants, the biosynthesis and
Esther Riemer +7 more
doaj +1 more source