Results 1 to 10 of about 2,351 (231)

A Role for Inositol Pyrophosphates in the Metabolic Adaptations to Low Phosphate in Arabidopsis [PDF]

Metabolites, 2021
Phosphate is a major plant macronutrient and low phosphate availability severely limits global crop productivity. In Arabidopsis, a key regulator of the transcriptional response to low phosphate, phosphate starvation response 1 (PHR1), is modulated by a ...
Eric S. Land, Caitlin A. Cridland, Branch Craige, Anna Dye, Sherry B. Hildreth, Rich F. Helm, Glenda E. Gillaspy, Imara Y. Perera   +7 more
doaj   +4 more sources

NUDIX hydrolases target specific inositol pyrophosphates and regulate phosphate homeostasis and bacterial pathogen susceptibility in Arabidopsis. [PDF]

J Integr Plant Biol
NUDIX‐type hydrolase enzymes of subclade I and II preferentially target the inositol pyrophosphate messengers 4‐ and 3‐InsP7, respectively. Inactivation of subclade II NUDTs disrupts phosphate homeostasis and enhances bacterial resistance, revealing connections between defense and nutrient signaling.
Schneider R, Lami K, Prucker I, Stolze SC, Strauß A, Schmidt JM, Bartsch SM, Langenbach K, Lange E, Ritter K, Furkert D, Faiß N, Kumar S, Shamim Hasan M, Makris A, Krusenbaum L, Wege S, Belay YZ, Kriescher S, The J, Harings M, Grundler FMW, Ried-Lasi MK, Schoof H, Gaugler P, Kamleitner M, Fiedler D, Nakagami H, Giehl RFH, Lahaye T, Bhattacharjee S, Jessen HJ, Gaugler V, Schaaf G.   +33 more
europepmc   +3 more sources

Human genome-wide RNAi screen identifies an essential role for inositol pyrophosphates in Type-I interferon response. [PDF]

PLoS Pathogens, 2014
The pattern recognition receptor RIG-I is critical for Type-I interferon production. However, the global regulation of RIG-I signaling is only partially understood. Using a human genome-wide RNAi-screen, we identified 226 novel regulatory proteins of RIG-
Niyas Kudukkil Pulloor, Sajith Nair, Kathleen McCaffrey, Aleksandar D Kostic, Pradeep Bist, Jeremy D Weaver, Andrew M Riley, Richa Tyagi, Pradeep D Uchil, John D York, Solomon H Snyder, Adolfo García-Sastre, Barry V L Potter, Rongtuan Lin, Stephen B Shears, Ramnik J Xavier, Manoj N Krishnan   +16 more
doaj   +3 more sources

Inositol pyrophosphates activate the vacuolar transport chaperone complex in yeast by disrupting a homotypic SPX domain interaction [PDF]

Nature Communications, 2023
Many proteins involved in eukaryotic phosphate homeostasis are regulated by SPX domains. In yeast, the vacuolar transporter chaperone (VTC) complex contains two such domains, but mechanistic details of its regulation are not well understood.
Joka Pipercevic, Bastian Kohl, Ruta Gerasimaite, Véronique Comte-Miserez, Sarah Hostachy, Thomas Müntener, Elia Agustoni, Henning Jacob Jessen, Dorothea Fiedler, Andreas Mayer, Sebastian Hiller   +10 more
doaj   +2 more sources

Inositol pyrophosphates promote the interaction of SPX domains with the coiled-coil motif of PHR transcription factors to regulate plant phosphate homeostasis [PDF]

Nature Communications, 2021
Rebekka Wild, Jinsheng Zhu, Kristina Sturm   +2 more
exaly   +4 more sources

Inositol Pyrophosphates: Signaling Molecules with Pleiotropic Actions in Mammals [PDF]

Molecules, 2020
Inositol pyrophosphates (PP-IPs) such as 5-diphosphoinositol pentakisphosphate (5-IP7) are inositol metabolites containing high-energy phosphoanhydride bonds.
Seulgi Lee, Min-Gyu Kim, Hyoungjoon Ahn, Seyun Kim   +3 more
doaj   +2 more sources

Correction: Human Genome-Wide RNAi Screen Identifies an Essential Role for Inositol Pyrophosphates in Type-I Interferon Response. [PDF]

PLoS Pathogens, 2014
The PLOS Pathogens Staff
doaj   +7 more sources

Novel Substrates for Kinases Involved in the Biosynthesis of Inositol Pyrophosphates and Their Enhancement of ATPase Activity of a Kinase [PDF]

Molecules, 2021
IP6K and PPIP5K are two kinases involved in the synthesis of inositol pyrophosphates. Synthetic analogs or mimics are necessary to understand the substrate specificity of these enzymes and to find molecules that can alter inositol pyrophosphate synthesis.
Raja Mohanrao, Ruth Manorama, Shubhra Ganguli, Mithun C. Madhusudhanan, Rashna Bhandari, Kana M. Sureshan   +5 more
doaj   +2 more sources

Cellular delivery and photochemical release of a caged inositol-pyrophosphate induces PH-domain translocation in cellulo [PDF]

Nature Communications, 2016
Photocaged inositol-pyrophosphates offer a tool to study cellular signalling, but their challenging synthesis has precluded any biological studies so far.
Igor Pavlovic, Divyeshsinh T. Thakor, Jessica R. Vargas, Colin J. McKinlay, Sebastian Hauke, Philipp Anstaett, Rafael C. Camuña, Laurent Bigler, Gilles Gasser, Carsten Schultz, Paul A. Wender, Henning J. Jessen   +11 more
doaj   +2 more sources

Can Inositol Pyrophosphates Inform Strategies for Developing Low Phytate Crops? [PDF]

Plants, 2020
Inositol pyrophosphates (PP-InsPs) are an emerging class of “high-energy” intracellular signaling molecules, containing one or two diphosphate groups attached to an inositol ring, that are connected with phosphate sensing, jasmonate signaling,
Catherine Freed, Olusegun Adepoju, Glenda Gillaspy   +2 more
doaj   +2 more sources