Overview of Inositol and Inositol Phosphates on Chemoprevention of Colitis-Induced Carcinogenesis
Molecules, 2020 Chronic inflammation is one of the most common and well-recognized risk factors for human cancer, including colon cancer. Inflammatory bowel disease (IBD) is defined as a longstanding idiopathic chronic active inflammatory process in the colon, including
Samuel E. Weinberg +4 more
doaj +1 more source
Synergism between Inositol Polyphosphates and TOR Kinase Signaling in Nutrient Sensing, Growth Control, and Lipid Metabolism in Chlamydomonas [PDF]
, 2016 The networks that govern carbon metabolism and control intracellular carbon partitioning in photosynthetic cells are poorly understood. Target of Rapamycin (TOR) kinase is a conserved growth regulator that integrates nutrient signals and modulates cell
Allen, Doug K. +7 more
core +1 more source
Targeting the Inositol Pyrophosphate Biosynthetic Enzymes in Metabolic Diseases [PDF]
Molecules, 2020 In mammals, a family of three inositol hexakisphosphate kinases (IP6Ks) synthesizes the inositol pyrophosphate 5-IP7 from IP6. Genetic deletion of Ip6k1 protects mice from high fat diet induced obesity, insulin resistance and fatty liver. IP6K1 generated 5-IP7 promotes insulin secretion from pancreatic β-cells, whereas it reduces insulin signaling in ...
Sandip Mukherjee +2 more
openaire +4 more sources
Akt/PKB activation and insulin signaling: a novel insulin signaling pathway in the treatment of type 2 diabetes [PDF]
, 2014 Type 2 diabetes is a metabolic disease categorized primarily by reduced insulin sensitivity, β-cell dysfunction, and elevated hepatic glucose production.
Elliott, B.T. +3 more
core +4 more sources
Inositol polyphosphates regulate and predict yeast pseudohyphal growth phenotypes.
PLoS Genetics, 2018 Pseudohyphal growth is a nutrient-regulated program in which budding yeast form multicellular filaments of elongated and connected cells. Filamentous growth is required for virulence in pathogenic fungi and provides an informative model of stress ...
Kaitlyn L Norman +6 more
doaj +1 more source
Physics-based machine learning for modeling stochastic IP3-dependent calcium dynamics [PDF]
arXiv, 2021 We present a machine learning method for model reduction which incorporates domain-specific physics through candidate functions. Our method estimates an effective probability distribution and differential equation model from stochastic simulations of a reaction network.
arxiv
Ratiometric fluorescent sensing of pyrophosphate with sp$^{3}$-functionalized single-walled carbon nanotubes [PDF]
Nat. Commun. 2024, 15, 706Inorganic pyrophosphate is a key molecule in many biological processes from DNA synthesis to cell metabolism. Here we introduce sp$^{3}$-functionalized (6,5) single-walled carbon nanotubes (SWNTs) with red-shifted defect emission as near-infrared luminescent probes for the optical detection and quantification of inorganic pyrophosphate.
arxiv +1 more source
Absence of gap for infinite half--integer spin ladders with an odd number of legs [PDF]
, 1995 A proof is presented for the absence of gap for spin $1/2$ ladders with an odd number of legs, in the infinite leg length limit. This result is relevant to the current discussion of coupled one--dimensional spin systems, a physical realization of which are vanadyl pyrophosphate, (VO)$_2$P$_2$O$_7$, and stoichiometric Sr$_{n-1}$ Cu$_{n+1}$ O$_{2n ...
arxiv +1 more source
Flux Sampling Suggests Metabolic Signatures of High Antibody‐Producing CHO Cells
Biotechnology and Bioengineering, EarlyView.ABSTRACT Chinese hamster ovary (CHO) cells remain the industry standard for producing numerous therapeutic proteins, particularly monoclonal antibodies (mAbs). However, achieving higher recombinant protein titers remains an ongoing challenge and a fundamental understanding of the cellular mechanism driving improved bioprocess performance remains ...
Kate E. Meeson +9 more
wiley +1 more source
Fluorination Influences the Bioisostery of Myo‐Inositol Pyrophosphate Analogs
Chemistry – A European Journal, 2023 AbstractInositol pyrophosphates (PP−IPs) are densely phosphorylated messenger molecules involved in numerous biological processes. PP−IPs contain one or two pyrophosphate group(s) attached to a phosphorylated myo‐inositol ring. 5PP−IP5 is the most abundant PP−IP in human cells. To investigate the function and regulation by PP−IPs in biological contexts,
Sarah Hostachy +8 more
openaire +3 more sources