Results 101 to 110 of about 2,351 (231)

The Concise Guide to PHARMACOLOGY 2025/26: Enzymes

British Journal of Pharmacology, Volume 182, Issue S1, Page S307-S403, December 2025.
The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander, Doriano Fabbro, Alasdair J. Gibb, Eamonn Kelly, Alistair A. Mathie, Chloe J. Peach, Emma L. Veale, Jane F. Armstrong, Elena Faccenda, Simon D. Harding, Christopher Southan, Jamie A. Davies, Stephanie Annett, Detlev Boison, Kathryn Elisa Burns, Carmen Dessauer, Jürg Gertsch, Nuala Ann Helsby, Angelo A. Izzo, Rennolds Ostrom, Ester Pagano, Andreas Papapetropoulos, Nigel J. Pyne, Susan Pyne, Tracy Robson, Roland Seifert, Johannes‐Peter Stasch, Csaba Szabo, Mario van der Stelt, Albert van der Vliet, Val Watts, Szu Shen Wong   +31 more
wiley   +1 more source

Inositol Pyrophosphates as Versatile Metabolic Messengers

Annual Review of Biochemistry
Discovered in 1993, inositol pyrophosphates are evolutionarily conserved signaling metabolites whose versatile modes of action are being increasingly appreciated. These include their emerging roles as energy regulators, phosphodonors, steric/allosteric regulators, and G protein–coupled receptor messengers.
Latika, Nagpal, Sining, He, Feng, Rao, Solomon H, Snyder   +3 more
openaire   +2 more sources

Analysis of weighted co-regulatory networks in maize provides insights into new genes and regulatory mechanisms related to inositol phosphate metabolism [PDF]

, 2016
Sub-network 1 and 2 of “magenta2”, node annotation.
Chunyi Zhang, Ling Jiang, Qianqian Zhao, Rumei Chen, Shaojun Zhang, Shuai Ma, Wenzhu Yang, Xiaojin Zhou, Xiaoqing Liu, Ye Li, Yunliu Fan   +10 more
core   +6 more sources

Reviewer #3 (Public Review): Inositol Pyrophosphate Dynamics Reveals Control of the Yeast Phosphate Starvation Program Through 1,5-IP8 and the SPX Domain of Pho81

, 2023
Caroline Gutjahr, Kim Geun-Don, Qiu Danye, Liu Guizhen, Mayer Lydie Michaillat, Muhammed Jamsheer K., Jessen Henning Jacob, Mayer Andreas   +7 more
openalex   +2 more sources

The Concise Guide to PHARMACOLOGY 2025/26: Transporters

British Journal of Pharmacology, Volume 182, Issue S1, Page S404-S496, December 2025.
The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander, Alasdair J. Gibb, Eamonn Kelly, Alistair A. Mathie, Chloe J. Peach, Emma L. Veale, Jane F. Armstrong, Elena Faccenda, Simon D. Harding, Christopher Southan, Jamie A. Davies, Laura Amarosi, Catriona M. H. Anderson, Philip M. Beart, Stefan Broer, Paul A. Dawson, Gergely Gyimesi, Bruno Hagenbuch, James R. Hammond, Jules C. Hancox, Michal Hershfinkel, Ken‐ichi Inui, Yoshikatsu Kanai, Stephan Kemp, Edmund R. S. Kunji, Gavin Stewart, Sotiria Tavoulari, David T. Thwaites, Tiziano Verri   +28 more
wiley   +1 more source

Inositol, neural tube closure and the prevention of neural tube defects [PDF]

, 2016
Susceptibility to neural tube defects (NTDs), such as anencephaly and spina bifida is influenced by genetic and environmental factors including maternal nutrition.
Copp, AJ, Greene, ND, Leung, KY
core   +1 more source

Toward understanding myometrial regulation : metabolomic investigation reveals new pathways of oxytocin and ritodrine activity on the myometrium [PDF]

, 2016
In recent times, additional pathways involved in the regulation of the myometrium have been suggested. This also holds true for the effect of drugs such as oxytocin (OT) and β-adrenergic agonists on the myometrium.
Bafor, Enitome E., Edrada-Ebel, RuAngelie, Rowan, Edward G.   +2 more
core   +1 more source

Simultaneous Knockout of Tk1‐SST and Tk1‐FFT via CRISPR/Cas9 Enhances the Natural Rubber Accumulation in Taraxacum kok‐saghyz

Plant Biotechnology Journal, Volume 23, Issue 12, Page 5654-5676, December 2025.
ABSTRACT Taraxacum kok‐saghyz (TKS) synthesises natural rubber (NR) and inulin using sucrose as a carbon source. However, molecular mechanisms regulating inulin and NR accumulation remain largely unclear. Here, we report the generation of double‐gene homozygous mutants, 1‐sst1‐fft, by simultaneously knocking out two key genes responsible for inulin ...
Bi Qin, Xue Hou, Songle Fan, Chuang Li, Xiaoxiao Wang, Qiuhui Chen, Yushuang Yang, Pin Lin, Liang RuiNan Lu, Canni Fu, Ning Yang, Qiaoli Gao, Shanshan Zheng, Shizhong Liu   +13 more
wiley   +1 more source

Cellular Cations Control Conformational Switching of Inositol Pyrophosphate Analogues [PDF]

Chemistry – A European Journal, 2016
AbstractThe inositol pyrophosphate messengers (PP‐InsPs) are emerging as an important class of cellular regulators. These molecules have been linked to numerous biological processes, including insulin secretion and cancer cell migration, but how they trigger such a wide range of cellular responses has remained unanswered in many cases.
Anastasia Hager, Mingxuan Wu, Huanchen Wang, Nathaniel W. Brown, Stephen B. Shears, Nicolás Veiga, Dorothea Fiedler   +6 more
openaire   +3 more sources

A High-Throughput Screening-Compatible Strategy for the Identification of Inositol Pyrophosphate Kinase Inhibitors. [PDF]

PLoS ONE, 2016
Pharmacological tools-'chemical probes'-that intervene in cell signaling cascades are important for complementing genetically-based experimental approaches.
Brandi M Baughman, Huanchen Wang, Yi An, Dmitri Kireev, Michael A Stashko, Henning J Jessen, Kenneth H Pearce, Stephen V Frye, Stephen B Shears   +8 more
doaj   +1 more source