Results 11 to 20 of about 2,351 (231)
Preparation of quality inositol pyrophosphates. [PDF]
J Vis Exp, 2011 Myo-inositol is present in nature either unmodified or in more complex phosphorylated derivates. Of the latest, the two most abundant in eukaryotic cells are inositol pentakisphosphate (IP(5;)) and inositol hexakisphosphate (phytic acid or IP(6;)).
Loss O +4 more
europepmc +8 more sources
Biosynthesis and possible functions of inositol pyrophosphates in plants [PDF]
Frontiers in Plant Science, 2015 Inositol phosphates (InsPs) are intricately tied to lipid signaling, as at least one portion of the inositol phosphate signaling pool is derived from hydrolysis of the lipid precursor, phosphatidyl inositol (4,5) bisphosphate. The focus of this review is
Sarah Phoebe Williams +2 more
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Inositol pyrophosphates: why so many phosphates? [PDF]
Adv Biol Regul, 2015 The inositol pyrophosphates (PP-InsPs) are a specialized group of "energetic" signaling molecules found in yeasts, plants and animals. PP-InsPs boast the most crowded three dimensional phosphate arrays found in Nature; multiple phosphates and diphosphates are crammed around the six-carbon, inositol ring.
Shears SB.
europepmc +5 more sources
Inositol Pyrophosphates: Energetic, Omnipresent and Versatile Signalling Molecules. [PDF]
J Indian Inst Sci, 2017 Inositol pyrophosphates (PP-IPs) are a class of energy-rich signalling molecules found in all eukaryotic cells. These are derivatives of inositol that contain one or more diphosphate (or pyrophosphate) groups in addition to monophosphates. The more abundant and best studied PP-IPs are diphosphoinositol pentakisphosphate (IP7) and bis-diphosphoinositol ...
Shah A, Ganguli S, Sen J, Bhandari R.
europepmc +5 more sources
Regulation of inositol metabolism is fine-tuned by inositol pyrophosphates in Saccharomyces cerevisiae. [PDF]
J Biol Chem, 2013 Although inositol pyrophosphates have diverse roles in phosphate signaling and other important cellular processes, little is known about their functions in the biosynthesis of inositol and phospholipids. Here, we show that KCS1, which encodes an inositol pyrophosphate kinase, is a regulator of inositol metabolism.
Ye C, Bandara WM, Greenberg ML.
europepmc +6 more sources
Analysis of Dictyostelium discoideum inositol pyrophosphate metabolism by gel electrophoresis. [PDF]
PLoS ONE, 2014 The social amoeba Dictyostelium discoideum was instrumental in the discovery and early characterization of inositol pyrophosphates, a class of molecules possessing highly-energetic pyrophosphate bonds.
Francesca Pisani +5 more
doaj +3 more sources
Inositol pyrophosphates as multifaceted metabolites in the regulation of mammalian signaling networks [PDF]
Animal Cells and Systems, 2018 Inositol pyrophosphates (PP-IPs) such as 5-diphosphoinositol pentakisphosphate (5-IP7) are inositol metabolites with high-energy phosphoanhydride bonds. The formation of PP-IPs is catalyzed by two groups of enzymes, the IP6 kinases and the PPIP5 kinases,
Seung Ju Park +3 more
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Metabolism and Functions of Inositol Pyrophosphates: Insights Gained from the Application of Synthetic Analogues [PDF]
Molecules, 2020 Inositol pyrophosphates (PP-InsPs) comprise an important group of intracellular, diffusible cellular signals that a wide range of biological processes throughout the yeast, plant, and animal kingdoms.
Stephen B. Shears, Huanchen Wang
doaj +2 more sources
Eukaryotic Phosphate Homeostasis: The Inositol Pyrophosphate Perspective [PDF]
Trends in Biochemical Sciences, 2017 Phosphate, as a cellular energy currency, essentially drives most biochemical reactions defining living organisms, and thus its homeostasis must be tightly regulated. Investigation into the role of inositol pyrophosphates (PP-IPs) has provided a novel perspective on the regulation of phosphate homeostasis.
Azevedo, C, Saiardi, A
openaire +6 more sources
eLife, 2023 Eukaryotic cells control inorganic phosphate to balance its role as essential macronutrient with its negative bioenergetic impact on reactions liberating phosphate.
Valentin Chabert +7 more
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