Preparation of quality inositol pyrophosphates. [PDF]
J Vis Exp, 2011 Myo-inositol is present in nature either unmodified or in more complex phosphorylated derivates. Of the latest, the two most abundant in eukaryotic cells are inositol pentakisphosphate (IP5) and inositol hexakisphosphate (phytic acid or IP6). IP5 and IP6
Loss O +4 more
europepmc +7 more sources
Metabolism and Functions of Inositol Pyrophosphates: Insights Gained from the Application of Synthetic Analogues [PDF]
Molecules, 2020 Inositol pyrophosphates (PP-InsPs) comprise an important group of intracellular, diffusible cellular signals that a wide range of biological processes throughout the yeast, plant, and animal kingdoms.
Stephen B. Shears, Huanchen Wang
doaj +5 more sources
A Role for Inositol Pyrophosphates in the Metabolic Adaptations to Low Phosphate in Arabidopsis [PDF]
Metabolites, 2021 Phosphate is a major plant macronutrient and low phosphate availability severely limits global crop productivity. In Arabidopsis, a key regulator of the transcriptional response to low phosphate, phosphate starvation response 1 (PHR1), is modulated by a ...
Eric S. Land +7 more
doaj +3 more sources
Novel Substrates for Kinases Involved in the Biosynthesis of Inositol Pyrophosphates and Their Enhancement of ATPase Activity of a Kinase [PDF]
Molecules, 2021 IP6K and PPIP5K are two kinases involved in the synthesis of inositol pyrophosphates. Synthetic analogs or mimics are necessary to understand the substrate specificity of these enzymes and to find molecules that can alter inositol pyrophosphate synthesis.
Raja Mohanrao +5 more
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Can Inositol Pyrophosphates Inform Strategies for Developing Low Phytate Crops? [PDF]
Plants, 2020 Inositol pyrophosphates (PP-InsPs) are an emerging class of “high-energy” intracellular signaling molecules, containing one or two diphosphate groups attached to an inositol ring, that are connected with phosphate sensing, jasmonate signaling,
Catherine Freed +2 more
doaj +3 more sources
Absolute Quantitation of Inositol Pyrophosphates by Capillary Electrophoresis Electrospray Ionization Mass Spectrometry [PDF]
Journal of Visualized Experiments, 2021 Inositol pyrophosphates (PP-InsPs) are an important group of intracellular signaling molecules. Derived from inositol phosphates (InsPs), these molecules feature the presence of at least one energetic pyrophosphate moiety on the myo-inositol ring.
Eisenbeis, VB +3 more
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Tandem inactivation of inositol pyrophosphatases Asp1, Siw14, and Aps1 illuminates functional redundancies in inositol pyrophosphate catabolism in fission yeast [PDF]
mBioInositol pyrophosphates 5-IP7, 1-IP7, and 1,5-IP8 are eukaryal signaling molecules that influence cell physiology, especially phosphate homeostasis. In fission yeast, 1,5-IP8 and 1-IP7 impact gene expression by acting as agonists of RNA 3'-processing and
Beate Schwer +5 more
doaj +3 more sources
Inositol Pyrophosphates: Energetic, Omnipresent and Versatile Signalling Molecules. [PDF]
J Indian Inst Sci, 2017 Inositol pyrophosphates (PP-IPs) are a class of energy-rich signalling molecules found in all eukaryotic cells. These are derivatives of inositol that contain one or more diphosphate (or pyrophosphate) groups in addition to monophosphates.
Shah A, Ganguli S, Sen J, Bhandari R.
europepmc +6 more sources
Emerging roles of inositol pyrophosphates as key modulators of fungal pathogenicity [PDF]
Virulence, 2018 Inositol pyrophosphates (PP-IPs) are energy-rich small molecules that are omnipresent in eukaryotic cells, from yeast to mammals, playing central roles in overall cellular homeostasis as a diverse and multifaceted class of intracellular messengers ...
Hyun Ah Kang
doaj +3 more sources
Dissecting the activation of insulin degrading enzyme by inositol pyrophosphates and their bisphosphonate analogs. [PDF]
Chem Sci, 2021 Inositol poly- and pyrophosphates (InsPs and PP-InsPs) are densely phosphorylated eukaryotic messengers, which are involved in numerous cellular processes.
Hostachy S +8 more
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