Inositol pyrophosphates regulate JMJD2C-dependent histone demethylation. [PDF]
Proc Natl Acad Sci U S A, 2013 Significance Epigenetic modifications of chromatin are emerging as important regulatory mechanisms of many nuclear processes. Numerous proteins have been identified that mediate these modifications in a dynamic manner. However, less is known about the signaling pathways that transduce upstream signals into chromatin changes. Here,
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Inositol Pyrophosphate-Controlled Kinetochore Architecture and Mitotic Entry in S. pombe [PDF]
Journal of Fungi, 2022 Inositol pyrophosphates (IPPs) comprise a specific class of signaling molecules that regulate central biological processes in eukaryotes. The conserved Vip1/PPIP5K family controls intracellular IP8 levels, the highest phosphorylated form of IPPs present ...
Natascha Andrea Kuenzel +6 more
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Inositol Pyrophosphates Get the Vip1 Treatment [PDF]
Cell, 2007 Inositol pyrophosphates are unique signaling molecules implicated in the regulation of diverse cellular processes. Two new studies by Mulugu et al. (2007) and Lee et al. (2007) extend the biological and metabolic diversity of this class of molecules. They identify yeast Vip1 as a new inositol pyrophosphate synthase and show that the products of Vip1 ...
Sara Maria Nancy Onnebo, Adolfo Saiardi
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Inositol pyrophosphates promote the interaction of SPX domains with the coiled-coil motif of PHR transcription factors to regulate plant phosphate homeostasis. [PDF]
Nat Commun, 2021 Phosphorus is an essential nutrient taken up by organisms in the form of inorganic phosphate (Pi). Eukaryotes have evolved sophisticated Pi sensing and signaling cascades, enabling them to stably maintain cellular Pi concentrations.
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Versatile signaling mechanisms of inositol pyrophosphates.
Current Opinion in Chemical Biology, 2022 Inositol pyrophosphates (PP-InsPs) constitute a group of highly charged messengers, which regulate central biological processes in health and disease, such as cellular phosphate and general energy homeostasis. Deciphering the molecular mechanisms underlying PP-InsP-mediated signaling remains a challenge due to the unique properties of these molecules ...
Minh Nguyen Trung +2 more
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The inositol pyrophosphate pathway in health and diseases [PDF]
Biological Reviews, 2017 ABSTRACTInositol pyrophosphates (IPPs) are present in organisms ranging from plants, slime moulds and fungi to mammals. Distinct classes of kinases generate different forms of energetic diphosphate‐containing IPPs from inositol phosphates (IPs). Conversely, polyphosphate phosphohydrolase enzymes dephosphorylate IPPs to regenerate the respective IPs ...
Anutosh Chakraborty
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Correction for Rao et al., Inositol pyrophosphates promote tumor growth and metastasis by antagonizing liver kinase B1. [PDF]
Proc Natl Acad Sci U S A, 2020 CELL BIOLOGY Correction for “Inositol pyrophosphates promote tumor growth and metastasis by antagonizing liver kinase B1,” by Feng Rao, Jing Xu, Chenglai Fu, Jiyoung Y. Cha, Moataz M. Gadalla, Risheng Xu, James C. Barrow, and Solomon H. Snyder, which was
Feng Raoa +7 more
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Using native and synthetic genes to disrupt inositol pyrophosphates and phosphate accumulation in plants. [PDF]
Plant PhysiolInositol pyrophosphates are eukaryotic signaling molecules that have been recently identified as key regulators of plant phosphate sensing and homeostasis.
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Inositol pyrophosphates and their unique metabolic complexity: analysis by gel electrophoresis. [PDF]
PLoS ONE, 2009 BackgroundInositol pyrophosphates are a recently characterized cell signalling molecules responsible for the pyrophosphorylation of protein substrates. Though likely involved in a wide range of cellular functions, the study of inositol pyrophosphates has
Oriana Losito +3 more
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Inositol Pyrophosphates Inhibit Synaptotagmin-Dependent Exocytosis [PDF]
Biophysical Journal, 2014 Inositol pyrophosphates such as IP7 (5-diphosphoinositol pentakisphosphate) are highly energetic inositol metabolites containing pyrophosphate bonds. While IP7 are known to regulate various biological events like metabolism, the molecular site of IP7 action in vesicle trafficking remains elusive.
Tae Sun Lee +10 more
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