Results 31 to 40 of about 2,351 (231)

Inositol pyrophosphates inhibit synaptotagmin-dependent exocytosis. [PDF]

Proc Natl Acad Sci U S A, 2016
Significance Inositol phosphates have long been considered to be negative regulators of synaptic exocytosis, but the function of diphosphoinositol pentakisphosphate (IP 7 ) has remained elusive. We found that overexpression and depletion of inositol hexakisphosphate (IP
Lee TS, Lee JY, Kyung JW, Yang Y, Park SJ, Lee S, Pavlovic I, Kong B, Jho YS, Jessen HJ, Kweon DH, Shin YK, Kim SH, Yoon TY, Kim S.   +14 more
europepmc   +5 more sources

Using native and synthetic genes to disrupt inositol pyrophosphates and phosphate accumulation in plants. [PDF]

Plant Physiol
Freed C, Craige B, Donahue J, Cridland C, Williams SP, Pereira C, Kim J, Blice H, Owen J, Gillaspy G.   +9 more
europepmc   +2 more sources

Inositol Pyrophosphate Pyrotechnics [PDF]

Cell Metabolism, 2007
Physiologic roles of highly phosphorylated inositol phosphates, including those containing pyrophosphate groups, have been the focus of much recent interest. In the April 6, 2007 issue of Science, two papers (Lee et al., 2007; Mulugu et al., 2007) demonstrate the occurrence of a novel inositol pyrophosphate molecule in yeast and elucidate its role in ...
Bhandari, Rashna, Chakraborty, Anutosh, Snyder, Solomon H.   +2 more
openaire   +2 more sources

Inositol pyrophosphates regulate endocytic trafficking [PDF]

Proceedings of the National Academy of Sciences, 2002
The high energy potential and rapid turnover of the recently discovered inositol pyrophosphates, such as diphosphoinositol-pentakisphosphate and bis-diphosphoinositol-tetrakisphosphate, suggest a dynamic cellular role, but no specific functions have yet been established.
Adolfo, Saiardi, Catherine, Sciambi, J Michael, McCaffery, Beverly, Wendland, Solomon H, Snyder   +4 more
openaire   +2 more sources

The Vip1 inositol polyphosphate kinase family regulates polarized growth and modulates the microtubule cytoskeleton in fungi. [PDF]

PLoS Genetics, 2014
Microtubules (MTs) are pivotal for numerous eukaryotic processes ranging from cellular morphogenesis, chromosome segregation to intracellular transport. Execution of these tasks requires intricate regulation of MT dynamics.
Jennifer Pöhlmann, Carmen Risse, Constanze Seidel, Thomas Pohlmann, Visnja Jakopec, Eva Walla, Pascal Ramrath, Norio Takeshita, Sebastian Baumann, Michael Feldbrügge, Reinhard Fischer, Ursula Fleig   +11 more
doaj   +1 more source

Inositol pyrophosphates as mammalian cell signals. [PDF]

Sci Signal, 2011
Identification and knockout of their biosynthetic enzymes has shed light on the diverse functions of the inositol pyrophosphates.
Chakraborty A, Kim S, Snyder SH.
europepmc   +4 more sources

A structural exposé of noncanonical molecular reactivity within the protein tyrosine phosphatase WPD loop

Nature Communications, 2022
Inositol pyrophosphates (PP-IPs) regulate immunity and phosphate homeostasis. Here, the authors’ structural dissection of an Arabidopsis thaliana PP-IP phosphatase reveals that substrates drive their own hydrolysis and identifies a highly elusive ...
Huanchen Wang, Lalith Perera, Nikolaus Jork, Guangning Zong, Andrew M. Riley, Barry V. L. Potter, Henning J. Jessen, Stephen B. Shears   +7 more
doaj   +1 more source

Metabolic Consequences of Polyphosphate Synthesis and Imminent Phosphate Limitation

mBio, 2023
Cells stabilize intracellular inorganic phosphate (Pi) to compromise between large biosynthetic needs and detrimental bioenergetic effects of Pi.
Geun-Don Kim, Danye Qiu, Henning Jacob Jessen, Andreas Mayer   +3 more
doaj   +1 more source

Regulation of plant biotic interactions and abiotic stress responses by inositol polyphosphates

Frontiers in Plant Science, 2022
Inositol pyrophosphates (PP-InsPs), derivatives of inositol hexakisphosphate (phytic acid, InsP6) or lower inositol polyphosphates, are energy-rich signaling molecules that have critical regulatory functions in eukaryotes. In plants, the biosynthesis and
Esther Riemer, Naga Jyothi Pullagurla, Ranjana Yadav, Priyanshi Rana, Henning J. Jessen, Marília Kamleitner, Gabriel Schaaf, Debabrata Laha   +7 more
doaj   +1 more source

Scalable Chemoenzymatic Synthesis of Inositol Pyrophosphates [PDF]

Biochemistry, 2019
The inositol pyrophosphates (PP-InsPs) are an important group of cellular messengers that influence a broad range of biological processes. To elucidate the functions of these high-energy metabolites at the biochemical level, access to the purified molecules is required.
Robert Puschmann, Robert K. Harmel, Dorothea Fiedler   +2 more
openaire   +2 more sources