Scalable Chemoenzymatic Synthesis of Inositol Pyrophosphates. [PDF]
Biochemistry, 2019 The inositol pyrophosphates (PP-InsPs) are an important group of cellular messengers which influence a broad range of biological processes. To elucidate the functions of these high-energy metabolites at the biochemical level, access to the purified ...
R. Puschmann +2 more
semanticscholar +3 more sources
Inositol pyrophosphates impact phosphate homeostasis via modulation of RNA 3' processing and transcription termination. [PDF]
Nucleic Acids Res, 2019 Fission yeast phosphate acquisition genes pho1, pho84, and tgp1 are repressed in phosphate-rich medium by transcription of upstream lncRNAs. Here we show that phosphate homeostasis is subject to metabolite control by inositol pyrophosphates (IPPs ...
Sanchez AM, Garg A, Shuman S, Schwer B.
europepmc +2 more sources
Eukaryotic Phosphate Homeostasis: The Inositol Pyrophosphate Perspective [PDF]
Trends in Biochemical Sciences, 2017 Phosphate, as a cellular energy currency, essentially drives most biochemical reactions defining living organisms, and thus its homeostasis must be tightly regulated.
Azevedo, C, Saiardi, A
core +6 more sources
Inositol pyrophosphates promote tumor growth and metastasis by antagonizing liver kinase B1. [PDF]
Proc Natl Acad Sci U S A, 2015 Rao F +7 more
europepmc +4 more sources
Inositol pyrophosphates mediated the apoptosis induced by hypoxic injury in bone marrow-derived mesenchymal stem cells by autophagy. [PDF]
Stem Cell Res Ther, 2019 To investigate the potential effect of IP7 on the autophagy and apoptosis of bone marrow mesenchymal stem cells (BM-MSCs) caused by hypoxia. BM-MSCs isolated from adult male C57BL/6 mice were exposed to normoxic condition and hypoxic stress for 6 h, 12 h,
Deng J +9 more
europepmc +2 more sources
The inositol pyrophosphate metabolism of Dictyostelium discoideum does not regulate inorganic polyphosphate (polyP) synthesis [PDF]
, 2021 Initial studies on the inositol phosphates metabolism were enabled by the social amoeba Dictyostelium discoideum. The abundant amount of inositol hexakisphosphate (IP6 also known as Phytic acid) present in the amoeba allowed the discovery of the more ...
Borghi, F +8 more
core +2 more sources
Inositol pyrophosphates regulate endocytic trafficking [PDF]
Proceedings of the National Academy of Sciences, 2002 The high energy potential and rapid turnover of the recently discovered inositol pyrophosphates, such as diphosphoinositol-pentakisphosphate and bis-diphosphoinositol-tetrakisphosphate, suggest a dynamic cellular role, but no specific functions have yet been established.
Adolfo Saiardi +4 more
openalex +5 more sources
Inositol pyrophosphates inhibit synaptotagmin-dependent exocytosis. [PDF]
Proc Natl Acad Sci U S A, 2016 Significance Inositol phosphates have long been considered to be negative regulators of synaptic exocytosis, but the function of diphosphoinositol pentakisphosphate (IP 7 ) has remained elusive. We found that overexpression and depletion of inositol hexakisphosphate (IP 6 ) kinase ...
Lee TS +14 more
europepmc +6 more sources
Biomolecules, 2023 Inositol phosphates constitute a family of highly charged messenger molecules that play diverse roles in cellular processes. The various phosphorylation patterns they exhibit give rise to a vast array of different compounds.
Kevin Ritter +4 more
doaj +2 more sources
Photolysis of cell-permeant caged inositol pyrophosphates controls oscillations of cytosolic calcium in a β-cell line. [PDF]
Chem Sci, 2019 β-Cells respond directly to the intracellular photochemical release of caged inositol pyrophosphate isomers with modulations of oscillations in cytosolic Ca2+.
Hauke S +9 more
europepmc +2 more sources