Structural and biochemical characterization of Siw14: A protein-tyrosine phosphatase fold that metabolizes inositol pyrophosphates. [PDF]
J Biol Chem, 2018 Inositol pyrophosphates (PP-InsPs) are “energetic” intracellular signals that are ubiquitous in animals, plants, and fungi; structural and biochemical characterization of PP-InsP metabolic enzymes provides insight into their evolution, reaction ...
Wang H +4 more
europepmc +2 more sources
Correction: Human Genome-Wide RNAi Screen Identifies an Essential Role for Inositol Pyrophosphates in Type-I Interferon Response. [PDF]
PLoS Pathogens, 2014 doaj +7 more sources
Inositol pyrophosphates as mammalian cell signals. [PDF]
Sci Signal, 2011 Identification and knockout of their biosynthetic enzymes has shed light on the diverse functions of the inositol pyrophosphates.
Chakraborty A, Kim S, Snyder SH.
europepmc +4 more sources
Inositol Pyrophosphates as Versatile Metabolic Messengers.
Annual Review of BiochemistryDiscovered in 1993, inositol pyrophosphates are evolutionarily conserved signaling metabolites whose versatile modes of action are being increasingly appreciated.
Latika Nagpal +3 more
semanticscholar +3 more sources
Inositol pyrophosphates: why so many phosphates? [PDF]
Adv Biol Regul, 2015 The inositol pyrophosphates (PP-InsPs) are a specialized group of "energetic" signaling molecules found in yeasts, plants and animals. PP-InsPs boast the most crowded three dimensional phosphate arrays found in Nature; multiple phosphates and diphosphates are crammed around the six-carbon, inositol ring.
Shears SB.
europepmc +5 more sources
Protein pyrophosphorylation by inositol pyrophosphates is a posttranslational event [PDF]
Proceedings of the National Academy of Sciences, 2007 In a previous study, we showed that the inositol pyrophosphate diphosphoinositol pentakisphosphate (IP 7 ) physiologically phosphorylates mammalian and yeast proteins. We now report that this phosphate transfer reflects pyrophosphorylation. Thus, proteins must be prephosphorylated by ATP to prime them for IP
Rashna Bhandari +13 more
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Inositol pyrophosphates: metabolism and signaling
Cellular and Molecular Life Sciences, 2006 Inositol pyrophosphates belong to the diverse family of inositol polyphosphate species that have a range of signaling functions. Since the discovery of inositol pyrophosphates in the early 1990s, enormous progress has been achieved in characterising this class of molecules, linking their biological presence to a wide range of cellular functions ...
M. C. Bennett +3 more
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Generation of inositol polyphosphates through a phospholipase C-independent pathway involving carbohydrate and sphingolipid metabolism in Trypanosoma cruzi [PDF]
mBioInositol phosphates are involved in a myriad of biological roles and activities such as Ca2+ signaling, phosphate homeostasis, energy metabolism, and disease pathogenicity.
Mayara S. Bertolini +9 more
doaj +2 more sources
Mammalian inositol polyphosphate multikinase synthesizes inositol 1,4,5-trisphosphate and an inositol pyrophosphate [PDF]
Proceedings of the National Academy of Sciences, 2001 Using a consensus sequence in inositol phosphate kinase, we have identified and cloned a 44-kDa mammalian inositol phosphate kinase with broader catalytic capacities than any other member of the family and which we designate mammalian inositol phosphate multikinase (mIPMK).
Adolfo Saiardi +6 more
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Inositol Pyrophosphate Pathways and Mechanisms: What Can We Learn from Plants? [PDF]
Molecules, 2020 The ability of an organism to maintain homeostasis in changing conditions is crucial for growth and survival. Eukaryotes have developed complex signaling pathways to adapt to a readily changing environment, including the inositol phosphate (InsP ...
Caitlin Cridland, Glenda Gillaspy
doaj +2 more sources