Results 51 to 60 of about 86,215 (260)

Human genome-wide RNAi screen identifies an essential role for inositol pyrophosphates in Type-I interferon response. [PDF]

PLoS Pathogens, 2014
The pattern recognition receptor RIG-I is critical for Type-I interferon production. However, the global regulation of RIG-I signaling is only partially understood. Using a human genome-wide RNAi-screen, we identified 226 novel regulatory proteins of RIG-
Niyas Kudukkil Pulloor, Sajith Nair, Kathleen McCaffrey, Aleksandar D Kostic, Pradeep Bist, Jeremy D Weaver, Andrew M Riley, Richa Tyagi, Pradeep D Uchil, John D York, Solomon H Snyder, Adolfo García-Sastre, Barry V L Potter, Rongtuan Lin, Stephen B Shears, Ramnik J Xavier, Manoj N Krishnan   +16 more
doaj   +2 more sources

The Inositol Pyrophosphate Biosynthetic Pathway of Trypanosoma cruzi

ACS Chemical Biology, 2021
Inositol phosphates (IPs) are phosphorylated derivatives of myo-inositol involved in the regulation of several cellular processes through their interaction with specific proteins. Their synthesis relies on the activity of specific kinases that use ATP as phosphate donor.
Brian S. Mantilla, Leticia D. Do Amaral, Henning J. Jessen, Roberto Docampo   +3 more
openalex   +5 more sources

Inositol Phosphates and Synthesizing Enzymes: Implications in Neurodegenerative Disorders [PDF]

Biomolecules
Inositol is a vital sugar molecule involved in numerous signaling pathways required for cellular homeostasis and cell survival. Myo-inositol and its phospho-derivatives, inositol phosphates (IPs), are the most prevalent forms of inositol found in living ...
Chisom J. Onu, Michael Adu, Mohamed Chakkour, Vikalp Kumar, Miriam L. Greenberg   +4 more
doaj   +2 more sources

Regulation of inositol metabolism is fine-tuned by inositol pyrophosphates in Saccharomyces cerevisiae. [PDF]

J Biol Chem, 2013
Although inositol pyrophosphates have diverse roles in phosphate signaling and other important cellular processes, little is known about their functions in the biosynthesis of inositol and phospholipids. Here, we show that KCS1, which encodes an inositol pyrophosphate kinase, is a regulator of inositol metabolism.
Ye C, Bandara WM, Greenberg ML.
europepmc   +5 more sources

Inositol pyrophosphates and Akt: Is the pancreatic β-cell the exception to the rule? [PDF]

Cellular Signalling, 2019
The inositol pyrophosphate, diphosphoinositol pentakisphosphate (IP7), is thought to negatively regulate the critical insulin signaling protein Akt/PKB. Knock down of the IP7-generating inositol hexakisphosphate kinase 1 (IP6K1) results in a concomitant ...
RYU, SUNG HO
core   +2 more sources

Inositol pyrophosphates: structure, enzymology and function. [PDF]

Cell Mol Life Sci, 2009
The stereochemistry of the inositol backbone provides a platform on which to generate a vast array of distinct molecular motifs that are used to convey information both in signal transduction and many other critical areas of cell biology. Diphosphoinositol phosphates, or inositol pyrophosphates, are the most recently characterized members of the ...
Barker CJ, Illies C, Gaboardi GC, Berggren PO.   +3 more
europepmc   +3 more sources

Inositol pyrophosphates modulate hydrogen peroxide signalling

Biochemical Journal, 2009
Inositol pyrophosphates are involved in a variety of cellular functions, but the specific pathways and/or downstream targets remain poorly characterized. In the present study we use Saccharomyces cerevisiae mutants to examine the potential roles of inositol pyrophosphates in responding to cell damage caused by ROS (reactive oxygen species).
Sara Maria Nancy Onnebo, Adolfo Saiardi
openalex   +6 more sources

Inositol Pyrophosphates Mediate the DNA-PK/ATM-p53 Cell Death Pathway by Regulating CK2 Phosphorylation of Tti1/Tel2. [PDF]

Mol Cell, 2020
Rao F, Cha J, Xu J, Xu R, Vandiver MS, Tyagi R, Tokhunts R, Koldobskiy MA, Fu C, Barrow R, Wu M, Fiedler D, Barrow JC, Snyder SH.   +13 more
europepmc   +2 more sources

Turnover of inositol polyphosphate pyrophosphates in pancreatoma cells.

Journal of Biological Chemistry, 1993
There is little information concerning the intracellular function of inositol 1,3,4,5,6-pentakis- and hexakisphosphate, despite their being the most abundant inositol polyphosphates. Current opinions that they play passive roles as antioxidants (Graf, E., Mahoney, J. R., Bryant, R. G., and Eaton, J. W. (1987) J. Biol. Chem.
Frank S. Menniti, R.N. Miller, James W. Putney, Stephen B. Shears   +3 more
openalex   +3 more sources

Inositol pyrophosphates as multifaceted metabolites in the regulation of mammalian signaling networks

Animal Cells and Systems, 2018
Inositol pyrophosphates (PP-IPs) such as 5-diphosphoinositol pentakisphosphate (5-IP7) are inositol metabolites with high-energy phosphoanhydride bonds. The formation of PP-IPs is catalyzed by two groups of enzymes, the IP6 kinases and the PPIP5 kinases,
Seung Ju Park, Seulgi Lee, Seung Eun Park, Seyun Kim   +3 more
doaj   +2 more sources