Results 61 to 70 of about 2,351 (231)

Inositol pyrophosphates modulate hydrogen peroxide signalling

Biochemical Journal, 2009
Inositol pyrophosphates are involved in a variety of cellular functions, but the specific pathways and/or downstream targets remain poorly characterized. In the present study we use Saccharomyces cerevisiae mutants to examine the potential roles of inositol pyrophosphates in responding to cell damage caused by ROS (reactive oxygen species).
Onnebo, Sara Maria Nancy, Saiardi, Adolfo   +1 more
openaire   +3 more sources

Two inositol hexakisphosphate kinases drive inositol pyrophosphate synthesis in plants [PDF]

The Plant Journal, 2014
SummaryInositol pyrophosphates are unique cellular signaling molecules with recently discovered roles in energy sensing and metabolism. Studies in eukaryotes have revealed that these compounds have a rapid turnover, and thus only small amounts accumulate.
Mintu, Desai, Padma, Rangarajan, Janet L, Donahue, Sarah P, Williams, Eric S, Land, Mihir K, Mandal, Brian Q, Phillippy, Imara Y, Perera, Victor, Raboy, Glenda E, Gillaspy   +9 more
openaire   +2 more sources

Identification of a major IP5 kinase in Cryptococcus neoformans confirms that PP-IP5/IP7, not IP6, is essential for virulence [PDF]

, 2016
Fungal inositol polyphosphate (IP) kinases catalyse phosphorylation of IP3 to inositol pyrophosphate, PP-IP5/IP7, which is essential for virulence of Cryptococcus neoformans.
Desmarini, D, Djordjevic, JT, Lev, S, Li, C, Saiardi, A, Sorrell, TC   +5 more
core   +2 more sources

Synergism between Inositol Polyphosphates and TOR Kinase Signaling in Nutrient Sensing, Growth Control, and Lipid Metabolism in Chlamydomonas [PDF]

, 2016
The networks that govern carbon metabolism and control intracellular carbon partitioning in photosynthetic cells are poorly understood. Target of Rapamycin (TOR) kinase is a conserved growth regulator that integrates nutrient signals and modulates cell
Allen, Doug K., Couso, Inmaculada, Diamond, Spencer, Evans, Bradley S., Li, Jia, Liu, Yu, Ma, Fangfang, Umen, James G.   +7 more
core   +1 more source

A systematic genetic screen for genes involved in sensing inorganic phosphate availability in Saccharomyces cerevisiae [PDF]

, 2017
Saccharomyces cerevisiae responds to changes in extracellular inorganic phosphate (P_i) availability by regulating the activity of the phosphate-responsive (PHO) signaling pathway, enabling cells to maintain intracellular levels of the essential nutrient
Choi, Joonhyuk, O’Shea, Erin K., Rabinowitz, Joshua D., Rajagopal, Abbhirami, Xu, Yi-Fan   +4 more
core   +3 more sources

Cellular IP₆ Levels Limit HIV Production while Viruses that Cannot Efficiently Package IP₆ Are Attenuated for Infection and Replication [PDF]

, 2019
Summary: HIV-1 hijacks host proteins to promote infection. Here we show that HIV is also dependent upon the host metabolite inositol hexakisphosphate (IP6) for viral production and primary cell replication.
Böcking, Till, Faysal, K. M.Rifat, Fletcher, Adam J., Freed, Eric O., James, Leo C., Kleinpeter, Alex, Mallery, Donna L., Novikova, Mariia, Saiardi, Adolfo, Vaysburd, Marina, Wilson, Miranda S.C.   +10 more
core   +3 more sources

Overview of Inositol and Inositol Phosphates on Chemoprevention of Colitis-Induced Carcinogenesis

Molecules, 2020
Chronic inflammation is one of the most common and well-recognized risk factors for human cancer, including colon cancer. Inflammatory bowel disease (IBD) is defined as a longstanding idiopathic chronic active inflammatory process in the colon, including
Samuel E. Weinberg, Le Yu Sun, Allison L. Yang, Jie Liao, Guang Yu Yang   +4 more
doaj   +1 more source

Role of the inositol pyrophosphate multikinase Kcs1 in Cryptococcus inositol metabolism [PDF]

Fungal Genetics and Biology, 2018
Cryptococcus neoformans is the most common cause of deadly fungal meningitis. This fungus has a complex inositol acquisition and utilization system, and our previous studies have shown the importance of inositol utilization in cryptococcal development and virulence. However, how inositol utilization is regulated in this fungus remains unknown.
Guojian, Liao, Yina, Wang, Tong-Bao, Liu, Gurkirat, Kohli, Weidong, Qian, Erika, Shor, Selvakumar, Subbian, Chaoyang, Xue   +7 more
openaire   +2 more sources

High intensity exercise decreases IP6K1 muscle content & improves insulin sensitivity in glucose intolerant individuals [PDF]

, 2017
Context Insulin resistance in skeletal muscle contributes to whole body hyperglycaemia and the secondary complications associated with type 2 diabetes.
Dunning-Foreman, P., Dunning-Foreman, P., Elliott, B., Elliott, B., Howard, D., Howard, D., Mackenzie, R.W.A., Mackenzie, R.W.A., Markiv, A., Markiv, A., McGrady, M., McGrady, M., Naufahu, J., Naufahu, J., Watt, P.W., Watt, P.W.   +15 more
core   +5 more sources

Inositol polyphosphates regulate and predict yeast pseudohyphal growth phenotypes.

PLoS Genetics, 2018
Pseudohyphal growth is a nutrient-regulated program in which budding yeast form multicellular filaments of elongated and connected cells. Filamentous growth is required for virulence in pathogenic fungi and provides an informative model of stress ...
Kaitlyn L Norman, Christian A Shively, Amberlene J De La Rocha, Nebibe Mutlu, Sukanya Basu, Paul J Cullen, Anuj Kumar   +6 more
doaj   +1 more source