Inositol Pyrophosphates and Phosphate Sensing in Plants
The FASEB Journal, 2019 Phosphate (Pi) is an essential nutrient for plants, required for plant growth and seed viability. Under Pi stress, plants undergo dynamic changes to leverage available Pi.
G. Gillaspy +7 more
semanticscholar +2 more sources
How inositol pyrophosphates control cellular phosphate homeostasis? [PDF]
Advances in Biological Regulation, 2012 Phosphorus in his phosphate PO(4)(3-) configuration is an essential constituent of all life forms. Phosphate diesters are at the core of nucleic acid structure, while phosphate monoester transmits information under the control of protein kinases and ...
Saiardi, A
core +5 more sources
A High-Throughput Screening-Compatible Strategy for the Identification of Inositol Pyrophosphate Kinase Inhibitors. [PDF]
PLoS ONE, 2016 Pharmacological tools-'chemical probes'-that intervene in cell signaling cascades are important for complementing genetically-based experimental approaches.
Brandi M Baughman +8 more
doaj +3 more sources
Nucleolar Architecture Is Modulated by a Small Molecule, the Inositol Pyrophosphate 5-InsP7 [PDF]
Biomolecules, 2023 Inositol pyrophosphates (PP-InsPs); are a functionally diverse family of eukaryotic molecules that deploy a highly-specialized array of phosphate groups as a combinatorial cell-signaling code.
Soumyadip Sahu +6 more
doaj +2 more sources
Intimate connections: Inositol pyrophosphates at the interface of metabolic regulation and cell signaling. [PDF]
J Cell Physiol, 2018 Shears SB.
europepmc +2 more sources
Inositol Pyrophosphates Regulate Cell Growth and the Environmental Stress Response by Activating the HDAC Rpd3L [PDF]
Cell Reports, 2013 Cells respond to stress and starvation by adjusting their growth rate and enacting stress defense programs. In eukaryotes this involves inactivation of TORC1, which in turn triggers downregulation of ribosome and protein synthesis genes and upregulation ...
Jeremy Worley +2 more
doaj +2 more sources
Inositol pyrophosphates in cell death and life [PDF]
Cell Cycle, 2011 Michael A. Koldobskiy, Solomon H. Snyder
openalex +4 more sources
Inositol pyrophosphate catabolism by three families of phosphatases regulates plant growth and development. [PDF]
PLoS GeneticsInositol pyrophosphates (PP-InsPs) are nutrient messengers whose cellular levels are precisely regulated. Diphosphoinositol pentakisphosphate kinases (PPIP5Ks) generate the active signaling molecule 1,5-InsP8.
Florian Laurent +10 more
doaj +2 more sources
The emerging roles of inositol pyrophosphates in eukaryotic cell physiology
Journal of Biosciences, 2015 Inositol pyrophosphates are water soluble derivatives of inositol that contain pyrophosphate or diphosphate moieties in addition to monophosphates. The best characterised inositol pyrophosphates, are IP7 (diphosphoinositol pentakisphosphate or PP-IP5), and IP8 (bisdiphosphoinositol tetrakisphosphate or (PP)2-IP4).
Swarna Gowri Thota, R. Bhandari
semanticscholar +3 more sources
A small signaling domain controls PPIP5K phosphatase activity in phosphate homeostasis [PDF]
Nature CommunicationsInositol pyrophosphates (PP-InsPs) are eukaryotic nutrient messengers. The N-terminal kinase domain of diphosphoinositol pentakisphosphate kinase (PPIP5K) generates the messenger 1,5-InsP8, the C-terminal phosphatase domain catalyzes PP-InsP breakdown ...
Pierre Raia +8 more
doaj +2 more sources