Results 71 to 80 of about 2,351 (231)

Role of transporters in regulating mammalian intracellular inorganic phosphate

Frontiers in Pharmacology, 2023
This review summarizes the current understanding of the role of plasma membrane transporters in regulating intracellular inorganic phosphate ([Pi]In) in mammals. Pi influx is mediated by SLC34 and SLC20 Na+-Pi cotransporters.
Michael L. Jennings
doaj   +1 more source

Inositol Phosphates and Synthesizing Enzymes: Implications in Neurodegenerative Disorders

Biomolecules
Inositol is a vital sugar molecule involved in numerous signaling pathways required for cellular homeostasis and cell survival. Myo-inositol and its phospho-derivatives, inositol phosphates (IPs), are the most prevalent forms of inositol found in living ...
Chisom J. Onu, Michael Adu, Mohamed Chakkour, Vikalp Kumar, Miriam L. Greenberg   +4 more
doaj   +1 more source

A theoretical and experimental NMR study of the prototropic tautomerism of tris(tetrabutylammonium) hydrogen pyrophosphate salt in solution and in the solid-state [PDF]

, 2015
The structure of tris(tetrabutylammonium)hydrogen pyrophosphate(HPP) has been studied in solution and in the solid-state by 31P NMR. GIAO/DFT calculations of the isolated molecule in its open and closed conformations, of their water complexes and the ...
Alkorta, Ibon, Claramunt, Rosa M., Elguero, José, Sanz, Dionisia   +3 more
core   +1 more source

The Contribution of Cholesterol and Squalene Synthase in Cancer: Molecular Mechanisms, Lipid Rafts and Therapeutic Approaches

Medicinal Research Reviews, EarlyView.
ABSTRACT A plethora of cellular signaling pathways are dysregulated in cancer cells, promoting carcinogenesis and migration. Cholesterol has recently been linked to cancer by several subcellular mechanisms, especially by its involvement in the formation of lipid rafts, which promote oncogenic signaling and cancer cell invasion. Squalene synthase (SQS),
Danai Mavridi, Theodora Katavati, Angeliki P. Kourounakis   +2 more
wiley   +1 more source

Inositol Pyrophosphates Inhibit Synaptotagmin-Dependent Exocytosis [PDF]

Biophysical Journal, 2014
Inositol pyrophosphates such as IP7 (5-diphosphoinositol pentakisphosphate) are highly energetic inositol metabolites containing pyrophosphate bonds. While IP7 are known to regulate various biological events like metabolism, the molecular site of IP7 action in vesicle trafficking remains elusive.
Lee, TS Lee, Tae Sun, Lee, JY Lee, Joo-Young, Yang, Y Yang, Yoosoo, Lee, S Lee, Seulgi, Kim, YR Kim, Young-ran, Kong, B Kong, Byoungjae, Jho, YS Jho, Yong Seok, Kweon, DH Kweon, Dae-Hyuk, Shin, YK Shin, Yeon-Kyun, Yoon, TY Yoon, Tae-Young, Kim, S Kim, Seyun   +10 more
openaire   +1 more source

Fluorination Influences the Bioisostery of Myo‐Inositol Pyrophosphate Analogs

Chemistry – A European Journal, 2023
AbstractInositol pyrophosphates (PP−IPs) are densely phosphorylated messenger molecules involved in numerous biological processes. PP−IPs contain one or two pyrophosphate group(s) attached to a phosphorylated myo‐inositol ring. 5PP−IP5 is the most abundant PP−IP in human cells. To investigate the function and regulation by PP−IPs in biological contexts,
Sarah Hostachy, Huanchen Wang, Guangning Zong, Katy Franke, Andrew M. Riley, Peter Schmieder, Barry V. L. Potter, Stephen B. Shears, Dorothea Fiedler   +8 more
openaire   +4 more sources

Proteome Analysis of Corynebacterium diphtheriae–Macrophage Interaction

PROTEOMICS, EarlyView.
ABSTRACT Contact of Corynebacterium diphtheriae with macrophages induces adaptations on both bacterial and cellular sides. The study presented here was aiming to shed light on the simultaneous intracellular adaptation of the bacteria and changes in the proteome of the phagocytes in response to the internalization of C. diphtheriae.
Luca Musella, Jens Möller, Christopher Lischer, Julio Vera‐Gonzalez, Jörg Hofmann, Lisa Ott, Andreas Burkovski   +6 more
wiley   +1 more source

Inositol Trisphosphate 3-Kinase B (InsP3KB) as a Physiological Modulator of Myelopoiesis [PDF]

, 2014
Inositol trisphosphate 3-kinase B (InsP3KB) belongs to a family of kinases that convert inositol 1,4,5-trisphosphate (Ins(1,4,5)P3 or IP3) to inositol 1,3,4,5-tetrakisphosphate (Ins(1,3,4,5)P4).
Chai, Li, Erneux, Christophe, Gao, Chong, Hattori, Hidenori, Jia, Yonghui, Li, Yitang, Loison, Fabien, Luo, Hongbo, Park, Shin-Young, Schurmans, Stephane, Silberstein, Leslie E.   +10 more
core   +1 more source

Inositol Pyrophosphate-Controlled Kinetochore Architecture and Mitotic Entry in S. pombe

Journal of Fungi, 2022
Inositol pyrophosphates (IPPs) comprise a specific class of signaling molecules that regulate central biological processes in eukaryotes. The conserved Vip1/PPIP5K family controls intracellular IP8 levels, the highest phosphorylated form of IPPs present ...
Natascha Andrea Kuenzel, Abel R. Alcázar-Román, Adolfo Saiardi, Simon M. Bartsch, Sarune Daunaraviciute, Dorothea Fiedler, Ursula Fleig   +6 more
doaj   +1 more source

Engineering Cyanobacteria for High‐Yield Photosynthetic Isoprene Production With Long‐Term Phenotypic Stability

Plant Biotechnology Journal, EarlyView.
Center: Cyanobacterial isoprene production from CO2 and sunlight. Top: CRISPR‐editing for generation of markerless production strains. Top right: Long‐term production assay for strain stability assessment. Bottom right: Engineering of MEP pathway and surrounding metabolism for bottleneck idenfication. Bottom left: Relief of bottleneck by overproduction
Kim N. Janssen, Paul Bolay, Adrian Tüllinghoff, Jörg Toepel, Daniel Spindler, Bruno Bühler, Pia Lindberg   +6 more
wiley   +1 more source