Results 81 to 90 of about 86,215 (260)
Protein pyrophosphorylation: moving forward [PDF]
, 2016 Genetic ablation of inositol pyrophosphate synthesis has established the fundamental importance of this class of molecules to the eukaryote cell. These studies, however, must be complemented by cell biology and biochemical approaches to appreciate the ...
Saiardi, A
core +3 more sources
ITPK1 is an InsP6/ADP phosphotransferase that controls phosphate signaling in Arabidopsis [PDF]
, 2021 In plants, phosphate (Pi) homeostasis is regulated by the interaction of PHR transcription factors with stand-alone SPX proteins, which act as sensors for inositol pyrophosphates.
Fiedler, D +15 more
core
Inositols in Insulin Signaling and Glucose Metabolism [PDF]
, 2018 In the past decades, both the importance of inositol for human health and the complex interaction between glucose and inositol have been the subject of increasing consideration. Glucose has been shown to interfere with cellular transmembrane transport of
Bevilacqua, Arturo, Bizzarri, Mariano
core +1 more source
Nature Communications, 2020 Myo-Inositol phosphates (InsPs) and pyrophosphates (PP-InsPs) are important second messengers but their analysis remains challenging. Here, the authors develop a capillary electrophoresis-mass spectrometry method for the identification and quantitation ...
Danye Qiu +14 more
doaj +1 more source
Role of Inositols and Inositol Phosphates in Energy Metabolism
Molecules, 2020 Recently, inositols, especially myo-inositol and inositol hexakisphosphate, also known as phytic acid or IP6, with their biological activities received much attention for their role in multiple health beneficial effects.
Saimai Chatree +4 more
doaj +1 more source
Transition behavior of the seizure dynamics modulated by the astrocyte inositol triphosphate noise [PDF]
, 2021 Epilepsy is a neurological disorder with recurrent seizures of complexity and randomness. Until now, the mechanism of epileptic randomness has not been fully elucidated. Inspired by the recent finding that astrocyte GTPase-activating protein (G-protein)-coupled receptors could be involved in stochastic epileptic seizures, we proposed a neuron-astrocyte
arxiv +1 more source
Role of the inositol pyrophosphate multikinase Kcs1 in Cryptococcus inositol metabolism [PDF]
Fungal Genetics and Biology, 2018 Cryptococcus neoformans is the most common cause of deadly fungal meningitis. This fungus has a complex inositol acquisition and utilization system, and our previous studies have shown the importance of inositol utilization in cryptococcal development and virulence. However, how inositol utilization is regulated in this fungus remains unknown.
Weidong Qian +8 more
openaire +3 more sources
Has Inositol Played Any Role in the Origin of Life? [PDF]
, 2017 Phosphorus, as phosphate, plays a paramount role in biology. Since phosphate transfer reactions are an integral part of contemporary life, phosphate may have been incorporated into the initial molecules at the very beginning.
Saiardi, A
core +1 more source
Contribution of polymorphic variation of inositol hexakisphosphate kinase 3 (IP6K3) gene promoter to the susceptibility to late onset Alzheimer's disease [PDF]
, 2016 Maintenance of electric potential and synaptic transmission are energetically demanding tasks that neuronal metabolism must continually satisfy. Inability to fulfil these energy requirements leads to the development of neurodegenerative disorders ...
Bruni, AC +6 more
core +1 more source
A Shigella type 3 effector protein co-opts host inositol pyrophosphates for activity
, 2021 Shigella spp. cause diarrhea by invading human intestinal epithelial cells. Effector proteins delivered into target host cells by the Shigella type 3 secretion system modulate host signaling pathways and processes in a manner that promotes infection. The
Thomas E. Wood +5 more
semanticscholar +1 more source