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Growth Hormone and Insulin-Like Growth Factor-1
2016Human growth hormone (GH) was first isolated from the human pituitary gland in 1945 and found to promote the growth of children with hypopituitarism. Since the formation of the World Anti-Doping Association, human GH has appeared on the list of forbidden substances.
Nicholls, A.R., Holt, Richard
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Insulin-Like Growth Factor 1 Expression in Thyroid Tumors
Applied Immunohistochemistry & Molecular Morphology, 2000Insulin-like growth factor 1 (IGF-1) likely is involved in thyrocyte proliferation via autocrine mechanisms, but limited data are available on its in vivo expression in thyroid neoplasms. This prompted us to explore IGF-1 expression at the protein and mRNA levels and IGF-1 receptor (IGF-1rec) immunoreactivity in normal and neoplastic thyroids (50 ...
Maiorano E +7 more
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Journal of Urology, 2002
Elevated serum levels of insulin-like growth factor-1 (IGF-1) have been consistently shown to be a risk factor for prostate cancer. Alterations in serum IGF-1 binding proteins 1 to 3 have also been associated with prostate cancer risk. A potentially important complication in these studies is that prostate tissue, perhaps especially malignant prostate ...
Glenn J, Bubley +7 more
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Elevated serum levels of insulin-like growth factor-1 (IGF-1) have been consistently shown to be a risk factor for prostate cancer. Alterations in serum IGF-1 binding proteins 1 to 3 have also been associated with prostate cancer risk. A potentially important complication in these studies is that prostate tissue, perhaps especially malignant prostate ...
Glenn J, Bubley +7 more
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Cellular Immunology, 2005
Almost all of the previous studies with growth hormone (GH) have been done with exogenously supplied GH and, therefore, involve actions of the hormone through its receptor. However, the actions of endogenous or lymphocyte GH are still unclear. In a previous study, we showed that overexpression of GH (GHo) in a lymphoid cell line resulted in protection ...
Douglas A, Weigent, Robyn E, Arnold
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Almost all of the previous studies with growth hormone (GH) have been done with exogenously supplied GH and, therefore, involve actions of the hormone through its receptor. However, the actions of endogenous or lymphocyte GH are still unclear. In a previous study, we showed that overexpression of GH (GHo) in a lymphoid cell line resulted in protection ...
Douglas A, Weigent, Robyn E, Arnold
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Insulin-like Growth Factor-1 Deficiency
2019Since insulin-like growth factor-1 (IGF-1) measurement has become widely known to reflect cumulative growth hormone (GH) secretion, it is not surprising for clinicians to be tempted to use IGF-1 levels to not only screen for GH excess but for GH deficiency also (Le Roith D. Seminars in medicine of the Beth Israel Deaconess Medical Center.
Thomas Ittoop, S. Sethu K. Reddy
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Insulin-like growth factor-1 expression in reflux nephropathy
Pediatric Surgery International, 2004Reflux nephropathy (RN) is recognised as a major cause of end-stage renal failure in children and young adults. Insulin-like growth factor-1 (IGF-1), a peptide growth factor produced by collecting ducts, and its receptor, insulin-like growth factor-1 receptor (IGF-1R), are present in the glomeruli and basolateral membrane of renal proximal tubular ...
Boris, Chertin +2 more
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Targeting insulin-like growth factor 1 receptor in sarcomas
Current Opinion in Oncology, 2008The present review examines the rationale for targeting insulin-like growth factor-I receptor in sarcoma therapy and highlights some key issues that need to be addressed as clinical trials targeting insulin-like growth factor-I receptor proceed.Preclinical evidence supports proof of principle for targeting insulin-like growth factor-I receptor ...
Katia, Scotlandi, Piero, Picci
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2012
Strange, disturbing quality to subjects’ dream life. Difficulty concentrating. Headache in the forehead. Nasal congestion. Cramping abdominal pain associated with diarrhea or stool. Constipation with ineffectual urging. Strong uterine cramping with the menses. Premenstrual breast tenderness and swelling. Nausea. An aversion to chocolate and sweets.
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Strange, disturbing quality to subjects’ dream life. Difficulty concentrating. Headache in the forehead. Nasal congestion. Cramping abdominal pain associated with diarrhea or stool. Constipation with ineffectual urging. Strong uterine cramping with the menses. Premenstrual breast tenderness and swelling. Nausea. An aversion to chocolate and sweets.
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Elevated insulin‐like growth factor‐1 in Cushing’s disease
Clinical Endocrinology, 2019SummaryObjectiveTo determine if patients with untreated Cushing's disease have higher serum insulin‐like growth factor‐1 (IGF‐1) compared to matched controls, and if IGF‐1 decreases following remission of Cushing's disease.DesignRetrospective case‐control study matching Cushing's disease cases to control patients for adenoma size, age, sex, diabetic ...
Katherine English +3 more
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Peripheral insulin-like growth factor 1 in bipolar disorder
Psychiatry Research, 2017Bipolar disorder is a recurrent and highly incapacitating illness, related to inflammation and changes in the insulin-like growth factor 1 (IGF-1). The objective of this study was to evaluate serum levels of IGF-1 in bipolar disorder patients and its relation to inflammation. We included 31 patients with bipolar disorder and 33 healthy controls.
Emily G, da Silva +6 more
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