Estradiol, Progesterone, and Transforming Growth Factor α Regulate Insulin-Like Growth Factor Binding Protein-3 (IGFBP3) Expression in Mouse Endometrial Cells [PDF]
, 2009 Insulin-like growth factor 1 (IGF1) Is Involved in the proliferation of mouse and rat endometrial cells in a paracrine or autocrine manner. Insulin-like growth factor binding protein-3 (IGFBP3) modulates actions of IGFs directly or indirectly.
Hembree JR +10 more
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Onderstepoort Journal of Veterinary Research, 2013 The insulin-like growth factor system (insulin-like growth factor 1, insulin-like growth factor 2, insulin-like growth factor 1 receptor, insulin-like growth factor 2 receptor and six insulin-like growth factor-binding proteins) and insulin are essential
Stephen B. Hughes +3 more
doaj +1 more source
The antagonistic pleiotropy of insulin‐like growth factor 1 [PDF]
Aging Cell, 2021 AbstractWhile insulin‐like growth factor‐1 (IGF‐1) is a well‐established modulator of aging and longevity in model organisms, its role in humans has been controversial. In this study, we used the UK Biobank (n = 440,185) to resolve previous ambiguities in the relationship between serum IGF‐1 levels and clinical disease.
William B. Zhang +3 more
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Chronic inflammation and the growth hormone/insulin-like growth factor-1 axis
Central European Journal of Immunology, 2021 Interactions between growth hormone (GH), insulin-like growth factor-1 (IGF-1), and the immune system are complex, bidirectional, but not fully explained.
Ewelina Witkowska-Sędek, Beata Pyrżak
doaj +1 more source
Revisiting the IGF-1R as a breast cancer target
npj Precision Oncology, 2017 The type I insulin-like growth factor-1 receptor is a well-described target in breast cancer and multiple clinical trials examining insulin-like growth factor-1 receptor have been completed.
Roudy Chiminch Ekyalongo, Douglas Yee
doaj +1 more source
The Fascinating Interplay between Growth Hormone, Insulin-Like Growth Factor-1, and Insulin [PDF]
Endocrinology and MetabolismThis review intends to provide the reader with a practical overview of several (patho)physiological conditions in which knowledge of the interplay between growth hormone (GH), insulin-like growth factor-1 (IGF-1), and insulin is important.
Eline C. Nijenhuis-Noort +3 more
doaj +1 more source
Fibroblasts derived from long-lived insulin receptor substrate 1 null mice are not resistant to multiple forms of stress [PDF]
, 2014 Reduced signalling through the insulin/insulin-like growth factor-1 signalling (IIS) pathway is a highly conserved lifespan determinant in model organisms.
Page, Melissa M. +5 more
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Elevated serum insulin‐like growth factor 1 in recurrent aphthous stomatitis
Clinical and Experimental Dental Research, 2019 Over 100 million Americans experience recurrent aphthous stomatitis (RAS) at some point in life. To develop targeted drugs for RAS treatment, it is critical to identify its etiology. We determined if serum insulin‐like growth factor 1 (IGF‐1) and related
Lorena Baccaglini +3 more
doaj +1 more source
IGF1R (insulin-like growth factor 1 receptor) [PDF]
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011 Review on IGF1R (insulin-like growth factor 1 receptor), with data on DNA, on the protein encoded, and where the gene is implicated.
Bentov, Y, Werner, H
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Functional muscle hypertrophy by increased insulin-like growth factor 1 does not require dysferlin. [PDF]
, 2019 IntroductionDysferlin loss-of-function mutations cause muscular dystrophy, accompanied by impaired membrane repair and muscle weakness. Growth promoting strategies including insulin-like growth factor 1 (IGF-1) could provide benefit but may cause ...
Barton, Elisabeth R +9 more
core +1 more source