Insulin-like growth factor-1/insulin-like growth factor-1 receptor signalling in macrophages facilitates recovery from acute lung injury [PDF]
Annals of MedicineBackground No effective treatment strategy for acute respiratory distress syndrome (ARDS) has been established. Conflicting reports on the effects of insulin-like growth factor (IGF)-1 stimulation and the inhibition of IGF-1 receptor (IGF-1R) signalling ...
Miyuki Niisato +5 more
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Doxorubicin impairs the insulin-like growth factor-1 system and causes insulin-like growth factor-1 resistance in cardiomyocytes. [PDF]
PLoS ONE, 2015 Insulin-like growth factor-1 (IGF-1) promotes the survival of cardiomyocytes by activating type 1 IGF receptor (IGF-1R). Within the myocardium, IGF-1 action is modulated by IGF binding protein-3 (IGFBP-3), which sequesters IGF-1 away from IGF-1R.
Patrizia Fabbi +11 more
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Interoceptive Information of Physical Vigor Through Circulating Insulin‐Like Growth Factor 1 [PDF]
FASEB BioAdvancesThe brain relies on interoceptive feedback signals to regulate bodily functions. Female mice with low serum IGF‐1 levels (LID mice) exhibit reduced spontaneous running compared to control females, an effect not seen in males.
Jonathan A. Zegarra‐Valdivia +6 more
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Insulin-like growth factor-1 (IGF-1) empowering tendon regenerative therapies [PDF]
Frontiers in Bioengineering and BiotechnologyTendon injury is one of the most common musculoskeletal disorders that severely affect patients’ daily lives. Unfortunately, naturally healed tendons exhibit poor quality, as they have very limited regenerative ability.
Mingming Wang +4 more
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Iraqi Journal of Chemical and Petroleum Engineering, 2023 Insulin like growth factor-1 has metabolic and growth-related roles all over the body and is strongly associated and regulated by growth hormone. It is produced by almost any type of tissue, especially the liver.
Athraa F. Hasan +2 more
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مجلة بغداد للعلوم, 2023 The purpose of this study was to measure serum levels of insulin-like growth factor-binding protein (IGFBP7), Insulin-like Growth Factor 1 (IGF-1), Growth Hormone (GH), Interleukin 6 (IL-6) and insulin in acromegaly patients and healthy controls.
Layla Othman Farhan +3 more
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Molecular Characterization and Expression Analysis of Insulin-like Growth Factor-1 and Insulin-like Growth Factor Binding Protein-1 Genes in Qinghai-Tibet Plateau and Lowland [PDF]
Asian-Australasian Journal of Animal Sciences, 2015 Insulin-like growth factor-1 (IGF-1) and insulin-like growth factor binding protein-1 (IGFBP-1) play a pivotal role in regulating cellular hypoxic response.
Ya-bing Chen +3 more
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Antagonistic Autoantibodies to Insulin-Like Growth Factor-1 Receptor Associate with Poor Physical Strength [PDF]
, 2020 Natural autoantibodies to the IGF1 receptor (IGF1R-aAb) have been described in relation to Graves' ophthalmopathy. Other physiological roles of natural IGF1R-aAb are not known. We hypothesized that IGF1R-aAb may be related to muscle development.
Becker, Niels-Peter +7 more
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Advanced Biomedical Research, 2015 Background: The effect of the growth hormone on target cells is mediated by the insulin-like growth factor 1 (IGF-1). IGF-1 binds to the insulin-like growth factor binding proteins (IGFBPs) in blood and biological fluids.
Emad Khodadadi +4 more
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Changes in Insulin-like Growth Factor-1 Level in Patients with Sepsis and Septic Shock [PDF]
Korean Journal of Critical Care Medicine, 2016 Background Despite many ongoing, prospective studies on the topic, sepsis still remains one of the main causes of death in hospital. The hormone insulin-like growth factor 1 (IGF-1) has a similar molecular structure to that of insulin.
Sang Hoon Lee +10 more
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