Insulin-like growth factor-1 in CNS and cerebrovascular aging [PDF]
, 2013 Insulin-like growth factor-1 (IGF-1) is an important anabolic hormone that decreases with age. In the past two decades, extensive research has determined that the reduction in IGF-1 is an important component of the age-related decline in cognitive ...
Anna Csiszar +6 more
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Estudio inmunocitoquímico y molecular de cultivo primario de tejido molar
Biomédica: revista del Instituto Nacional de Salud, 2006 Introducción. La enfermedad trofoblástica gestacional comprende un conjunto de patologías caracterizadas por crecimiento e invasión anómalos del trofoblasto.
Yinth Andrea Bernal +6 more
doaj +1 more source
Relationship between Insulin-Like Growth Factor Type 1 and Intrauterine Growth
Acta Clinica Croatica, 2020 Insulin-like growth factor 1 (IGF-1) is a regulator of intrauterine growth, and circulating concentrations are reduced in intrauterine growth-restricted fetuses.
Lidija Banjac +5 more
doaj +1 more source
Insulin-Like Growth Factor-1 in Acute Ischemic Stroke
The Egyptian Journal of Neurology, Psychiatry and Neurosurgery, 2018 Background Cerebrovascular ischemic stroke is highly prevalent in the general population and is considered one of the frequent causes of mortality and disability.
Hala Shaheen +4 more
doaj +1 more source
Insulin and IGF-1 improve mitochondrial function in a PI-3K/Akt-dependent manner and reduce mitochondrial generation of reactive oxygen species in Huntington’s disease knock-in striatal cells [PDF]
, 2014 Akt, protein kinase B; ARE, antioxidant response element; Erk, extracellular signal-regulated kinase; CBP, CREB-binding protein; CREB, cAMP response-element (CRE) binding protein; CDK, cyclin-dependent kinase; DHE, dihydroethidium; Drp1, dynamin-related ...
Oliveira, Ana M. +4 more
core +1 more source
Insulin-like growth factor-1 receptors and insulin-like growth factor-1-like activity in human primary breast cancer [PDF]
Cancer, 1989 In the current study the authors have investigated whether human primary breast cancer specimens contain insulin-like growth factor-1 (IGF-1) receptors (IGF-1-R) or IGF-1-like activities. Simultaneously, epidermal growth factor (EGF) receptors (EGF-R) and cytosolic estrogen receptor (ER), progesterone receptor (PR), and EGF-like activity were ...
J A, Foekens +3 more
openaire +2 more sources
Effect of Iron Deficiency Anemia on IGF-1 Level Among Sample of Children
Advanced Medical Journal, 2023 Background and objectives:Iron-deficiency anemia is a worldwide nutritional problem and an important public health problem especially in developing countries.
Kani Rast Noori +1 more
doaj +1 more source
The signaling landscape of insulin-like growth factor 1. [PDF]
J Biol ChemThe sheer amplitude of biological actions of insulin-like growth factor I (IGF-1) affecting all types of cells in all tissues suggests a vast signaling landscape for this ubiquitous humoral signal. While the canonical signaling pathways primarily involve the Ras/MAPK and PI3K/AKT cascades, the evolutionary conservation of insulin-like peptides (ILPs ...
Khan MZ, Zugaza JL, Torres Aleman I.
europepmc +3 more sources
Differentiation of Murine Embryonic Stem Cells to Thyrocytes Requires Insulin and Insulin-like Growth Factor-1 [PDF]
, 2009 [Abstract] The mechanisms controlling thyrocyte development during embryonic stem (ES) cell differentiation have only been partially elucidated, although previous studies have suggested the participation of thyroid stimulating hormone (TSH) in these ...
Arufe, M.C., Lin, Reigh-Yi, Lu, Min
core +2 more sources
Paraoxonase 2 overexpression inhibits tumor development in a mouse model of ovarian cancer. [PDF]
, 2018 Ovarian cancer (OC) is most lethal malignancy among all gynecological cancer. Large bodies of evidences suggest that mitochondrial-derived ROS play a critical role in the development and progression of OC.
Devarajan, Asokan +11 more
core +3 more sources