Results 41 to 50 of about 714,864 (392)

Regulation of cardiac autophagy by insulin‐like growth factor 1 [PDF]

IUBMB Life, 2013
Insulin‐like growth factor‐1 (IGF‐1) signaling is a key pathway in the control of cell growth and survival. Three critical nodes in the IGF‐1 signaling pathway have been described in cardiomyocytes: protein kinase Akt/mammalian target of rapamycin (mTOR), Ras/Raf/extracellular signal‐regulated kinase (ERK), and phospholipase C (PLC)/inositol 1,4,5 ...
Troncoso, Rodrigo, Díaz Elizondo, Jessica, Espinoza, Sandra P., Navarro Márquez, Mario F., Oyarzún, Alejandra P., Riquelme, Jaime A., García Carvajal, Ivonne, Díaz Araya, Guillermo, García Nannig, Lorena, Hill, Joseph A., Lavandero González, Sergio   +10 more
openaire   +8 more sources

Chronic inflammation and the growth hormone/insulin-like growth factor-1 axis

Central European Journal of Immunology, 2021
Interactions between growth hormone (GH), insulin-like growth factor-1 (IGF-1), and the immune system are complex, bidirectional, but not fully explained.
Ewelina Witkowska-Sędek, Beata Pyrżak
doaj   +1 more source

Biomarkers of systemic inflammation and growth in early infancy are associated with stunting in young Tanzanian children [PDF]

, 2018
Stunting can afflict up to one-third of children in resource-constrained countries. We hypothesized that low-grade systemic inflammation (defined as elevations in serum C-reactive protein or alpha-1-acid glycoprotein) in infancy suppresses the growth ...
Aboud, Said, Duggan, Christopher P., Fawzi, Wafaie W., Kisenge, Rodrick, Liu, Enju, Locks, Lindsey, Manji, Karim P., McDonald, Christine M., Sudfeld, Christopher, Syed, Sana   +9 more
core   +1 more source

Revisiting the IGF-1R as a breast cancer target

npj Precision Oncology, 2017
The type I insulin-like growth factor-1 receptor is a well-described target in breast cancer and multiple clinical trials examining insulin-like growth factor-1 receptor have been completed.
Roudy Chiminch Ekyalongo, Douglas Yee
doaj   +1 more source

The Fascinating Interplay between Growth Hormone, Insulin-Like Growth Factor-1, and Insulin [PDF]

Endocrinology and Metabolism
This review intends to provide the reader with a practical overview of several (patho)physiological conditions in which knowledge of the interplay between growth hormone (GH), insulin-like growth factor-1 (IGF-1), and insulin is important.
Eline C. Nijenhuis-Noort, Kirsten A. Berk, Sebastian J. C. M. M. Neggers, Aart J. van der Lely   +3 more
doaj   +1 more source

How IGF-II Binds to the Human Type 1 Insulin-like Growth Factor Receptor. [PDF]

, 2020
Human type 1 insulin-like growth factor receptor (IGF-1R) signals chiefly in response to the binding of insulin-like growth factor I. Relatively little is known about the role of insulin-like growth factor II signaling via IGF-1R, despite the affinity of
Croll, Tristan I, Delaine, Carlie A, Forbes, Briony E, Kirk, Nicholas S, Lawrence, Michael C, Margetts, Mai B, Sandow, Jarrod J, Venugopal, Hariprasad, Webb, Andrew I, Xu, Yibin   +9 more
core   +2 more sources

Elevated serum insulin‐like growth factor 1 in recurrent aphthous stomatitis

Clinical and Experimental Dental Research, 2019
Over 100 million Americans experience recurrent aphthous stomatitis (RAS) at some point in life. To develop targeted drugs for RAS treatment, it is critical to identify its etiology. We determined if serum insulin‐like growth factor 1 (IGF‐1) and related
Lorena Baccaglini, Jonathan J. Shuster, Douglas W. Theriaque, Zaeema Naveed   +3 more
doaj   +1 more source

Circulating Levels of Insulin-like Growth Factor 1 and Insulin-like Growth Factor Binding Protein 3 Associate With Risk of Colorectal Cancer Based on Serologic and Mendelian Randomization Analyses

Gastroenterology, 2019
Background & Aims Human studies examining associations between circulating levels of insulin-like growth factor 1 (IGF1) and insulin-like growth factor binding protein 3 (IGFBP3) and colorectal cancer risk have reported inconsistent results. We conducted
N. Murphy, R. Carreras-Torres, M. Song, A. Chan, Richard M. Martin, N. Papadimitriou, N. Dimou, K. Tsilidis, B. Banbury, K. Bradbury, J. Bešević, S. Rinaldi, E. Riboli, A. Cross, R. Travis, C. Agnoli, D. Albanes, S. Berndt, S. Bézieau, D. Bishop, H. Brenner, D. Buchanan, N. Onland-Moret, A. Burnett-Hartman, P. Campbell, G. Casey, S. Castellví-Bel, J. Chang-Claude, M. Chirlaque, A. de la Chapelle, D. English, J. Figueiredo, S. Gallinger, G. Giles, S. Gruber, A. Gsur, J. Hampe, H. Hampel, T. Harrison, M. Hoffmeister, L. Hsu, Wen-Yi Huang, J. Huyghe, M. Jenkins, T. Keku, T. Kühn, S. Kweon, L. Le Marchand, Christopher I. Li, Li Li, A. Lindblom, V. Martín, R. Milne, V. Moreno, P. Newcomb, K. Offit, S. Ogino, J. Ose, Vittorio Perduca, A. Phipps, E. Platz, J. Potter, C. Qu, G. Rennert, Lori C. Sakoda, C. Schafmayer, R. Schoen, M. Slattery, C. Tangen, C. Ulrich, F. V. van Duijnhoven, B. van Guelpen, K. Visvanathan, P. Vodicka, L. Vodickova, Veronika Vymetálková, Hansong Wang, E. White, A. Wolk, M. Woods, A. Wu, W. Zheng, U. Peters, M. Gunter   +83 more
semanticscholar   +1 more source

Estradiol, Progesterone, and Transforming Growth Factor α Regulate Insulin-Like Growth Factor Binding Protein-3 (IGFBP3) Expression in Mouse Endometrial Cells [PDF]

, 2009
Insulin-like growth factor 1 (IGF1) Is Involved in the proliferation of mouse and rat endometrial cells in a paracrine or autocrine manner. Insulin-like growth factor binding protein-3 (IGFBP3) modulates actions of IGFs directly or indirectly.
Hembree JR, Huynh H, Munetoshi Kanayama, Ohtsuki T, Ohtsuki T, Pierro E, Sakae Takeuchi, Shiraga M, Sumio Takahashi, Takaoka M, Tetsuya Maekawa   +10 more
core   +1 more source

Insulin-Like Growth Factor 1: At the Crossroads of Brain Development and Aging

Frontiers in Cellular Neuroscience, 2017
Insulin-like growth factor 1 (IGF1) is a polypeptide hormone structurally similar to insulin. It is central to the somatotropic axis, acting downstream of growth hormone (GH).
S. Wrigley, D. Arafa, D. Tropea
semanticscholar   +1 more source