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Frontiers in Endocrinology, 2022 The growth hormone/insulin-like growth factor (GH/IGF) system, also called the pituitary-liver axis, has a somatotrophic role in the body. Although the GH/IGF system has always been regarded as a vertebrate-specific endocrine system, its actual origin ...
Mengyang Li
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The visceral adiposity index is associated with insulin sensitivity and IGF-I levels in adults with growth hormone deficiency [PDF]
, 2016 The visceral adiposity index, based on anthropometric and metabolic parameters, has been shown to be related to adipose tissue function and insulin sensitivity.
Ciresi, A. +3 more
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Growth Regulation by Insulin-like Growth Factor-I in Fish [PDF]
Bioscience, Biotechnology, and Biochemistry, 2000 Insulin-like growth factor-I (IGF-I) is a mitogenic polypeptide that plays an essential role in the regulation of development and somatic growth of vertebrates, mainly by mediating growth hormone actions. It has clearly been established that the structure of IGF-I and its biological function has been highly conserved among vertebrates.
Moriyama, Shunsuke +2 more
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Insulin-like growth factor -I deficiency, insulin sensitivity, and glucose metabolism [PDF]
, 2013 In children and adolescents, growth hormone (GH) and insulin-like growth factor-I (IGF-I) act in concert to stimulate linear growth; however, the effects on glucose metabolism are in opposition. GH increases insulin resistance by lipolysis. In contrast,
Ekström, Klas
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Insulin-like growth factor-II: new roles for an old actor
Frontiers in Endocrinology, 2012 IGF-II, traditionally considered as a growth factor implicated in growth of fetal tissues and cancer cells, is now emerging as a potential metabolic regulator.
Stefano eCianfarani
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Growth hormone treatment in non-growth hormone-deficient children [PDF]
Annals of Pediatric Endocrinology & Metabolism, 2014 Until 1985 growth hormone (GH) was obtained from pituitary extracts, and was available in limited amounts only to treat severe growth hormone deficiency (GHD).
Sandro Loche +3 more
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Insulin-like growth factor I during growth in bulls [PDF]
Reproduction Nutrition Développement, 1989 In 10 bulls, changes in blood plasma concentrations of insulin-like growth factor I (IGF1) were studied during rearing and during the ensuing growth period. IGF1 continuously increased from 32 micrograms/l at the age of 15 d to 194 micrograms/l at the age of 307 d together with body weight.
J. Blum, H. Ronge
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Insulin-like growth factor (IGF)-I and IGF binding proteins axis in diabetes mellitus [PDF]
Annals of Pediatric Endocrinology & Metabolism, 2015 Increasing evidence suggests an important role of the insulin-like growth factor (IGF)-IGF binding protein (IGFBP) axis in the maintenance of normal glucose and lipid metabolism. Significant changes occur in the local IGF-I-IGFBPs environment in response
Min Sun Kim, Dae-Yeol Lee
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PLoS ONE, 2018 Background and aimsNonalcoholic fatty liver disease is one of the major complications of obesity, occurring already in pediatric age. Insulin like growth factor-I has been proposed as a potential therapeutic agent for its beneficial effect in ...
Anna Alisi +6 more
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Insulin-Like Growth Factor-I and Insulin-Like Growth Factor Binding Protein-3 in Alzheimer's Disease [PDF]
The Journal of Clinical Endocrinology & Metabolism, 2012 Few large studies have been conducted to assess the relationship between circulating IGF and late-life cognition.The aim of the study was to assess the relationship between IGF-I and IGF binding protein-3 (IGFBP-3) serum levels and cognitive impairment, including Alzheimer's disease (AD).In this multicentric cross-sectional study, 694 elderly subjects (
Joël Coste +13 more
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