Results 271 to 280 of about 356,438 (307)

Engineered GM1 Intersects Between Mitochondrial and Synaptic Pathways to Ameliorate ALS Pathology

open access: yesAdvanced Science, EarlyView.
Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease driven by genetic and molecular disruptions affecting energy balance, protein homeostasis, and stress responses in nerve cells. Studies using human and rodent models identified convergent defects in mitochondria and synaptic function.
Federica Pilotto   +11 more
wiley   +1 more source

The Evolutionarily Conserved TPM1 Super‐Enhancer Drives Skeletal Muscle Regeneration via Mechanotransduction Signaling

open access: yesAdvanced Science, EarlyView.
By integrating biomechanical and epigenetic cues, the evolutionarily conserved TPM1 super‐enhancer drives myogenesis via TEAD4‐mediated chromatin looping. This mechanism produces species‐specific outputs (linear TPM1 mRNA in mice and CircTPM1 in bovine) that activate PI3K/AKT mechanotransduction and the MYH10/MYL3 axis to execute cytoskeletal ...
Ruimen Zhang   +27 more
wiley   +1 more source

Insulin-Like Growth Factor I

Drugs & Aging, 1999
M. Donath, J. Zapf
semanticscholar   +1 more source

Insulin-Like Growth Factor I

Drugs & Aging, 2000
E. Arvat, F. Broglio, E. Ghigo
semanticscholar   +1 more source

Plasma Insulin-Like Growth Factor-I and Prostate Cancer Risk: A Prospective Study

Science, 1998
J. Chan   +7 more
semanticscholar   +2 more sources

Insulin-like growth factor I

Springer Reference Medizin, 2019
M. Bidlingmaier
semanticscholar   +1 more source

Circulating concentrations of insulin-like growth factor I and risk of breast cancer

The Lancet, 1998
S. Hankinson   +8 more
semanticscholar   +1 more source

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