Insulin-like growth factor (IGF)-II- mediated fibrosis in pathogenic lung conditions.
PLoS ONE, 2019 Type 2 insulin-like growth factor (IGF-II) levels are increased in fibrosing lung diseases such as idiopathic pulmonary fibrosis (IPF) and scleroderma/systemic sclerosis-associated pulmonary fibrosis (SSc). Our goal was to investigate the contribution of
Sara M Garrett +4 more
doaj +1 more source
The impact of a human IGF-II analog ([Leu27]IGF-II) on fetal growth in a mouse model of fetal growth restriction. [PDF]
, 2016 Enhancing placental insulin-like growth factor (IGF) availability appears to be an attractive strategy for improving outcomes in fetal growth restriction (FGR).
Aplin, JD +5 more
core +2 more sources
Liver mitochondrial dysfunction is reverted by insulin-like growth factor II (IGF-II) in aging rats
Journal of Translational Medicine, 2011 Background Serum IGF-I and IGF-II levels decline with age. IGF-I replacement therapy reduces the impact of age in rats. We have recently reported that IGF-II is able to act, in part, as an analogous of IGF-I in aging rats reducing oxidative damage in ...
Castilla-Cortazar Inma +4 more
doaj +1 more source
The Intrathymic Expression of Insulin-Related Genes: Implications for Pathophysiology and Prevention of Type 1 Diabetes [PDF]
, 1998 peer reviewedRecent experimental work has challenged and shattered the old concept of a sequestration of pancreatic islet antigens from developing T-cells within the thymic environment.
Geenen, Vincent, Lefebvre, Pierre J.
core +1 more source
Changes in cardiac phenotype in hypertrophy and failure: From receptor to gene [PDF]
, 1997 The terminally differentiated adult cardiac myocyte cannot undergo cellular division. Growth of the heart in response to chronic hemodynamic overload therefore occurs through hypertrophy of the myocytes.
Heugten, H.A. (Han) van +1 more
core +3 more sources
Hematopoietic (stem) cells—The elixir of life?
FEBS Letters, EarlyView.The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo +4 more
wiley +1 more source
Insulin-like growth factors: Ligands, binding proteins, and receptors
Molecular Metabolism, 2021 Background: The insulin-like growth factor family of ligands (IGF-I, IGF-II, and insulin), receptors (IGF-IR, M6P/IGF-IIR, and insulin receptor [IR]), and IGF-binding proteins (IGFBP-1-6) play critical roles in normal human physiology and disease states.
Derek LeRoith +2 more
doaj +1 more source
Late recurrence of a malignant hypoglycemia‑inducing pelvic solitary fibrous tumor secreting high‑molecular‑weight insulin‑like growth factor‑II: A case report with protein analysis [PDF]
, 2016 The present study reports a case of recurrent malignant pelvic solitary fibrous tumor (SFT) that induced non-islet cell tumor hypoglycemia via high-molecular-weight insulin-like growth factor-II in a 72-year-old male patient. The tumor recurred ~12 years
FUKUDA Izumi +8 more
core +2 more sources
The role and implications of mammalian cellular circadian entrainment
FEBS Letters, EarlyView.At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley +1 more source
The endocrinology of aging [PDF]
, 1997 Most aging individuals die from atherosclerosis, cancer, or dementia; but in the oldest old, loss of muscle strength resulting in frailty is the limiting factor for an individual's chances of living an independent life until death. Three hormonal systems
Beld, A.W. (Annewieke) van den +2 more
core +1 more source