Results 141 to 150 of about 4,083 (158)

Insulin-regulated aminopeptidase and its compartment in dendritic cells

Molecular Immunology, 2013
Peptide epitopes presented by MHC class I molecules are produced through sequential proteolysis, frequently terminating with an aminoterminal trimming step. While the trimming enzymes processing endogenous MHC class I ligands in the endoplasmic reticulum have by now been characterized extensively, we have only recently identified an endosomal enzyme ...
Loredana, Saveanu, Joël, Babdor, Myriam, Lawand, Peter, van Endert   +3 more
openaire   +2 more sources

Insulin-Regulated Aminopeptidase

2004
Although insulin-regulated aminopeptidase (IRAP) was first described as a marker protein for specialized vesicles containing the insulin-responsive glucose transporter, GLUT4, the protein has subsequently been shown to be identical to oxytocinase or the AT4 receptor.
Siew Yeen Chai, Ruani Fernando, Siying Ye, Grantley R. Peck, Anthony L. Albiston   +4 more
openaire   +1 more source

Antidepressant-like effects of oxytocin in mice are dependent on the presence of insulin-regulated aminopeptidase

International Journal of Neuropsychopharmacology, 2013
Oxytocin is a neuromodulator with antidepressant-like effects. In vitro, oxytocin is rapidly cleaved by insulin-regulated aminopeptidase (IRAP). Oxytocin metabolites are known to exert strong central activities that are different from the effects of the ...
Ellen Loyens, Dimitri De Bundel, Heidi Demaegdt   +2 more
exaly   +2 more sources

The insulin-regulated aminopeptidase a companion and regulator of GLUT4

Frontiers in Bioscience, 2003
The insulin-regulated membrane aminopeptidase (IRAP) was originally identified in fat and muscle cells as a major protein in intracellular vesicles that also harbor the insulin-responsive glucose transporter GLUT4. IRAP, like GLUT4, predominantly localizes to these intracellular vesicles under basal conditions.
openaire   +2 more sources

Distinct distribution of GLUT4 and insulin regulated aminopeptidase in the mouse kidney

Regulatory Peptides, 2011
The physiological importance of the insulin responsive glucose transporter GLUT4 in adipocytes and muscle in maintaining glucose homeostasis is well established. A key protein associated with this process is the aminopeptidase IRAP which co-localizes with GLUT4 in specialized vesicles, where it plays a tethering role. In this study, we investigated the
Albiston, Anthony L, Yeatman, Holly R, Pham, Vi, Fuller, Stephanie J, Diwakarla, Shanti, Fernando, Ruani N, Chai, Siew Yeen   +6 more
openaire   +2 more sources

Aryl Sulfonamide Inhibitors of Insulin-Regulated Aminopeptidase Enhance Spine Density in Primary Hippocampal Neuron Cultures

ACS Chemical Neuroscience, 2016
The zinc metallopeptidase insulin regulated aminopeptidase (IRAP), which is highly expressed in the hippocampus and other brain regions associated with cognitive function, has been identified as a high-affinity binding site of the hexapeptide angiotensin
Shanti Diwakarla, Sudarsana Reddy Vanga, Yasmin Shamsudin   +2 more
exaly   +2 more sources

Cyclic insulin‐regulated aminopeptidase (IRAP)/AT₄ receptor ligands

Journal of Peptide Science, 2006
AbstractThe angiotensin IV receptor (AT4 receptor) is the insulin‐regulated aminopeptidase enzyme (IRAP, EC 3.4.11.3). This membrane‐spanning enzyme belongs to the M1 family of zinc‐dependent metallo‐peptidases. It has been proposed that AT4 receptor ligands exert their physiological effects by binding to the active site of IRAP and thereby inhibiting ...
Axen, A., Lindberg, G., Demaegdt, Heidi, Vauquelin, Georges, Karlen, A., Hallberg, M.   +5 more
openaire   +3 more sources

Reproduction and maternal behavior in insulin-regulated aminopeptidase (IRAP) knockout mice

Peptides, 2009
During human pregnancy, a circulating form of insulin-regulated aminopeptidase (IRAP EC 3.4.11.3), often termed oxytocinase or placental leucine aminopeptidase (PLAP), is present in plasma. It is proposed that circulating IRAP plays an important role in regulating the circulating levels of oxytocin and/or vasopressin during pregnancy.
Vi, Pham, Peta, Burns, Anthony L, Albiston, Holly R, Yeatman, Leelee, Ng, Shanti, Diwakarla, Siew Yeen, Chai   +6 more
openaire   +2 more sources

Identification of modulating residues defining the catalytic cleft of insulin-regulated aminopeptidase

Biochemistry and Cell Biology, 2008
Inhibition of insulin-regulated aminopeptidase (IRAP) has been demonstrated to facilitate memory in rodents, making IRAP a potential target for the development of cognitive enhancing therapies. In this study, we generated a 3-D model of the catalytic domain of IRAP based on the crystal structure of leukotriene A4 hydrolase (LTA4H).
Ye, Siying, Chai, Siew Yeen, Lew, Rebecca A, Ascher, David B, Morton, Craig J, Parker, Michael W, Albiston, Anthony L   +6 more
openaire   +3 more sources

Distribution and cellular localization of insulin‐regulated aminopeptidase in the rat central nervous system

Journal of Comparative Neurology, 2005
AbstractCentral infusions of angiotensin IV enhance spatial learning, memory retention and retrieval, neurotransmitter release, and long‐term potentiation via interaction with a specific, high‐affinity binding site. This site was recently purified and identified as the insulin‐regulated aminopeptidase (IRAP). This enzyme was previously characterized as
Fernando, Ruani N, Larm, Jari, Albiston, Anthony L, Chai, Siew Yeen   +3 more
openaire   +3 more sources