Results 131 to 140 of about 4,083 (158)
Ontogeny of digestive enzymes for weaning and role of dietary taurine supplementation in growth, survival and physiology of Channa striata juveniles. [PDF]
Sci RepGavhane SV +5 more
europepmc +1 more source
Mechanisms of Allosteric Inhibition of Insulin-Regulated Aminopeptidase
Journal of Molecular BiologyInhibition of Insulin-Regulated Aminopeptidase is being actively explored for the treatment of several human diseases and several classes of inhibitors have been developed although no clinical applications have been reported yet. Here, we combine enzymological analysis with x-ray crystallography to investigate the mechanism employed by two of the most ...
Anastasia Mpakali +2 more
exaly +5 more sources
Vasopressin is a physiological substrate for the insulin-regulated aminopeptidase IRAP [PDF]
American Journal of Physiology - Endocrinology and Metabolism, 2007 Insulin-regulated aminopeptidase (IRAP) is a membrane aminopeptidase and is homologous to the placental leucine aminopeptidase, P-LAP. IRAP has a wide distribution but has been best characterized in adipocytes and myocytes. In these cells, IRAP colocalizes with the glucose transporter GLUT4 to intracellular vesicles and, like GLUT4, translocates from ...
Susanna R Keller
exaly +3 more sources
Presence and regulation of insulin-regulated aminopeptidase in mouse macrophages [PDF]
JRAAS - Journal of the Renin-Angiotensin-Aldosterone System, 2014 Introduction: The insulin-regulated aminopeptidase (IRAP) is expressed in several cell types, where it is mainly located in specialized secretory endosomes that are quickly recruited to the cell surface upon cell type-specific activation.
Alexandros Nikolaou +2 more
exaly +4 more sources
Mutational analysis of the active site of human insulin-regulated aminopeptidase [PDF]
FEBS Journal, 2001 Insulin‐regulated aminopeptidase (IRAP) is a type II integral membrane protein belonging to the gluzincin family of metallopeptidases identified by the characteristic Zn2+‐coordination sequence element, HEXXH‐(18–64X)‐E. A second conserved sequence element, the GXMEN motif, positioned 22–32 amino acids N‐terminal to the Zn2+‐coordination sequence ...
Søren Vang
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Role of the Insulin-Regulated Aminopeptidase IRAP in Insulin Action and Diabetes
Biological and Pharmaceutical Bulletin, 2004 The insulin-regulated aminopeptidase (IRAP) is a member of the family of zinc-dependent membrane aminopeptidases. It is the homolog of the human placental leucine aminopeptidase (P-LAP). IRAP is expressed in different cell types but has been best characterized in two major insulin target cells, muscle and fat.
exaly +4 more sources
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Vasopressin inactivation: Role of insulin-regulated aminopeptidase
2020The physiological importance of vasopressin inactivation has long been appreciated, but the mechanisms and potential pathophysiologic roles of this process remain active subjects of research. Human Placental Leucine Aminopeptidase (P-LAP, encoded by the LNPEP gene) is an important determinant of vasopressinase activity during pregnancy and is ...
Don T, Li +2 more
openaire +2 more sources
Social behaviour is altered in the insulin-regulated aminopeptidase knockout mouse
Behavioural Brain Research, 2019Oxytocin, and the closely related neuropeptide, vasopressin, are both known to modulate social behaviours. The pro-social effects of oxytocin are well-documented and have generated much interest into its suitability as a therapeutic for disorders characterised by social dysfunction.
James D Mcfadyen +2 more
exaly +3 more sources