Results 121 to 130 of about 4,083 (158)

Inhibition of Insulin-regulated aminopeptidase in the brain : Evaluation of cognitive markers and restorative effects

Cognitive functions like learning and memory, are natural abilities that humans are highly dependent on to function properly. Neurological disorders like dementia, ischemia, and substance-use disorder may all severely impair cognitive functions.
Stam, Frida
core   +1 more source

Alzheimer's, angiotensin IV and an aminopeptidase

, 2004
The angiotensin AT4 receptor was originally defined as the specific, high affinity binding site for the hexapeptide angiotensin IV (Ang IV). Subsequently, the peptide LVV-hemorphin 7 was also demonstrated to be a bioactive ligand of the AT4 receptor ...
G Peck (12148926), R Fernando (11166417), S Chai (9882683), S Ye (7645880), A Albiston (13732981)   +4 more
core  

The Discovery of New Inhibitors of Insulin-Regulated Aminopeptidase by a High-Throughput Screening of 400,000 Drug-like Compounds. [PDF]

Int J Mol Sci
Gising J, Honarnejad S, Bras M, Baillie GL, McElroy SP, Jones PS, Morrison A, Beveridge J, Hallberg M, Larhed M.   +9 more
europepmc   +1 more source

AKT and AMP-activated protein kinase regulate TBC1D1 through phosphorylation and its interaction with the cytosolic tail of insulin-regulated aminopeptidase IRAP. [PDF]

J Biol Chem, 2018
Mafakheri S, Flörke RR, Kanngießer S, Hartwig S, Espelage L, De Wendt C, Schönberger T, Hamker N, Lehr S, Chadt A, Al-Hasani H.   +10 more
europepmc   +1 more source

A PCR-RFLP method for detection of the LNPEP encoding human insulin-regulated aminopeptidase (IRAP) rs4869317 polymorphism. [PDF]

Indian J Med Res, 2016
RamIrez-Expósito MJ, MartInez-Martos JM, Palomeque T, Lorite P.   +3 more
europepmc   +1 more source

Porcine insulin-regulated aminopeptidase: Cloning and expression

, 2005
Kristensen, Torsten, Andersen, R.S., Reinholdt, H., Romero, Paloma Rueda, Hald, S., Brenig, B., Bendixen, C.   +6 more
openaire   +2 more sources

Identification and development of specific inhibitors for insulin-regulated aminopeptidase as a new class of cognitive enhancers. [PDF]

Br J Pharmacol, 2011
Albiston AL, Diwakarla S, Fernando RN, Mountford SJ, Yeatman HR, Morgan B, Pham V, Holien JK, Parker MW, Thompson PE, Chai SY.   +10 more
europepmc   +1 more source

Integrated analysis of the adipocyte plasma membrane proteome reveals KCC1 and PIT2 as novel insulin-responsive transporters. [PDF]

J Biol Chem
Zhang Y, Cooke KC, Scavuzzo J, Cutler HB, Madsen S, Kearney AL, Conway OJ, Hawkins BL, Menon D, Humphrey SJ, Koumanov F, Stöckli J, Geddes TA, Fazakerley DJ, Diaz-Vegas A, Burchfield JG, James DE.   +16 more
europepmc   +1 more source

Evexomostat (SDX-7320), a methionine aminopeptidase type 2 inhibitor, stimulates weight loss and inhibits obesity-accelerated tumor growth. [PDF]

Front Oncol
Cornelius P, Mayes BA, Dannenberg AJ, Dufour PJ, Little S, Guzior DV, Petersen JS, Shanahan JM, Carver BJ.   +8 more
europepmc   +1 more source

Canonical and Alternative Pathways (Insulin and Exercise) of GLUT4 Synthesis, Signaling, Intracellular Clustering, and Recruitment to the Plasma Membrane. [PDF]

Int J Mol Sci
Ramos-Jiménez A, Rubio-Valles M, Guereca-Arvizuo J, Juárez-Oropeza MA, Ramos-Hernández JA, Chávez-Guevara IA, González-Rodríguez E, Moreno-Brito V, Hernández Torres RP.   +8 more
europepmc   +1 more source