Results 101 to 110 of about 4,083 (158)

Sexual and Metabolic Differences in Hippocampal Evolution: Alzheimer’s Disease Implications

Life
Sex differences in brain metabolism and their relationship to neurodegenerative diseases like Alzheimer’s are an important emerging topic in neuroscience.
José Manuel Martínez-Martos, Vanesa Cantón-Habas, Manuel Rich-Ruíz, María José Reyes-Medina, María Jesús Ramírez-Expósito, María del Pilar Carrera-González   +5 more
doaj   +1 more source

Cognitive-enhancing effects of angiotensin IV

BMC Neuroscience, 2008
Angiotensin IV is a derivative of the potent vasoconstrictor angiotensin II and it has been shown to enhance acquisition, consolidation and recall in animal models of learning and memory when administered centrally or peripherally.
Gard Paul R
doaj   +1 more source

Disulfide Cyclized Tripeptide Analogues of Angiotensin IV as Potent and Selective Inhibitors of Insulin-Regulated Aminopeptidase (IRAP)

, 2010
The insulin-regulated aminopeptidase (IRAP) localized in areas of the brain associated with memory and learning is emerging as a new promising therapeutic target for the treatment of memory dysfunctions.
Karlén, Anders,, Lindeberg, Gunnar,, Anders Hallberg, Hallberg, Mathias,, Heidi Demaegdt, Georges Vauquelin, Hallberg, Anders,, Gunnar Lindeberg, Andersson, Hanna,, Erdélyi, Máté, Hanna Andersson, Vauquelin, Georges,, Mathias Hallberg, Máté Erdélyi, Anders Karlén, Demaegdt, Heidi,   +15 more
core   +1 more source

Disulfide Cyclized Tripeptide Analogues of Angiotensin IV as Potent and Selective Inhibitors of Insulin-Regulated Aminopeptidase (IRAP)

, 2016
The insulin-regulated aminopeptidase (IRAP) localized in areas of the brain associated with memory and learning is emerging as a new promising therapeutic target for the treatment of memory dysfunctions.
Hanna Andersson (1408987), Mathias Hallberg (1656958), Anders Karlén (1281249), Gunnar Lindeberg (492163), Anders Hallberg (585061), Heidi Demaegdt (470499), Georges Vauquelin (2136157), Máté Erdélyi (1364241)   +7 more
core   +1 more source

Fetal pancreas size and maternal serum biomarkers glycated albumin and insulin-regulated aminopeptidase provide no potential for early prediction of gestational diabetes mellitus. [PDF]

Arch Gynecol Obstet, 2023
Guleroglu FY, Ozmen AB, Bakirci IT, Dogu SY, Yılmaz I, Cetin A.   +5 more
europepmc   +1 more source

Deletion of insulin-regulated aminopeptidase in mice decreases susceptibility to pentylenetetrazol-induced generalized seizures

, 2011
The peptide angiotensin IV (Ang IV) influences seizure susceptibility in rat and mouse models. Indeed, Ang IV has been shown to protect rats from limbic seizures in the focal pilocarpine model.
A. Schallier, Schallier, A., P. Vanderheyden, Loyens, E., Vanderheyden, P., Y. Michotte, De Bundel, D., S.Y. Chai, Chai, S.Y., Michotte, Y., D. De Bundel, Smolders, I., I. Smolders, E. Loyens   +13 more
core   +1 more source

Angiotensin IV Receptors in the Rat Prefrontal Cortex: Neuronal Expression and NMDA Inhibition

Biomedicines
Background: N-methyl-D-aspartate type glutamate receptors (NMDARs) are fundamental to neuronal physiology and pathophysiology. The prefrontal cortex (PFC), a key region for cognitive function, is heavily implicated in neuropsychiatric disorders ...
Zsolt Tamás Papp, Polett Ribiczey, Erzsébet Kató, Zsuzsanna E. Tóth, Zoltán V. Varga, Zoltán Giricz, Adrienn Hanuska, Mahmoud Al-Khrasani, Ákos Zsembery, Tibor Zelles, Laszlo G. Harsing, László Köles   +11 more
doaj   +1 more source

Regulation of insulin-regulated membrane aminopeptidase activity by its C-terminal domain

, 2011
The development of inhibitors of insulin-regulated aminopeptidase (TRAP), a membrane-bound zinc metallopeptidase, is a promising approach for the discovery of drugs for the treatment of memory loss such as that associated with Alzheimer's disease.
Brett Cromer (11895804), R Cherny (13454052), S CHAI (19974987), David Ascher (3543020), Michael Parker (131082), Craig Morton (7178012), Anthony Albiston (19974984), I Volitakis (9898775)   +7 more
core  

Putative Involvement of Endocrine Disruptors in the Alzheimer's Disease Via the Insulin-Regulated Aminopeptidase/GLUT4 Pathway. [PDF]

Curr Neuropharmacol, 2021
Ramírez-Expósito MJ, Martínez-Martos JM, Cantón-Habas V, Del Pilar Carrera-González M.   +3 more
europepmc   +1 more source

Potent Macrocyclic Inhibitors of Insulin-Regulated Aminopeptidase (IRAP) by Olefin Ring-Closing Methatesis

, 2011
Macrocyclic analogues of angiotensin IV (Ang IV, Val1-Tyr2-Ile3-His4-Pro5-Phe6) targeting the insulin-regulated aminopeptidase (IRAP) have been designed, synthesized, and evaluated biologically.
Demaegdt, H, Karlén, Anders, Erdelyi, Mate,, Lindeberg, G, Hallberg, Anders, Andersson, Hanna, ´Vaquelin, G, Hallberg, Matthias, Johansson, Anja   +8 more
core