Results 81 to 90 of about 4,083 (158)

Reduced Dietary Protein Induces Changes in the Dental Proteome

Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, Volume 346, Issue 2, Page 107-127, March 2026.
Low dietary protein (10%) from normal (20%) does change protein expression in tooth proteome and alter developmental pathways. Among the significant protein expressions changes are actin‐based myosins, tooth, and bone development proteins. Perplexingly tooth size is not altered, suggesting more nuanced phenotypic response to low dietary protein in ...
Robert W. Burroughs, Christopher J. Percival, Natasha S. Vitek   +2 more
wiley   +1 more source

Sub‐cellular localization of insulin‐regulated membrane aminopeptidase, IRAP to vesicles in neurons [PDF]

Journal of Neurochemistry, 2007
AbstractAngiotensin IV and LVV‐hemorphin 7 promote robust enhancing effects on learning and memory. These peptides are also competitive inhibitors of the insulin‐regulated membrane aminopeptidase, suggesting that the biological actions of these peptides may result from inhibition of IRAP activity.
Fernando, Ruani N, Luff, Susan E, Albiston, Anthony L, Chai, Siew Yeen   +3 more
openaire   +3 more sources

Synthesis, Evaluation and Proposed Binding Pose of Substituted Spiro‐Oxindole Dihydroquinazolinones as IRAP Inhibitors

ChemistryOpen, 2020
Insulin‐regulated aminopeptidase (IRAP) is a new potential macromolecular target for drugs aimed for treatment of cognitive disorders. Inhibition of IRAP by angiotensin IV (Ang IV) improves the memory and learning in rats.
Karin Engen, Dr. Sudarsana Reddy Vanga, Dr. Thomas Lundbäck, Dr. Faith Agalo, Vivek Konda, Dr. Annika Jenmalm Jensen, Prof. Johan Åqvist, Dr. Hugo Gutiérrez‐de‐Terán, Prof. Dr. Mathias Hallberg, Prof. Dr. Mats Larhed, Dr. Ulrika Rosenström   +10 more
doaj   +1 more source

Discovery of Lomitapide as a Novel Mast Cell Regulatory Agent Through Chemical Library Screening

European Journal of Immunology, Volume 56, Issue 2, February 2026.
Chemical library screening identified lomitapide as a novel mast cell (MC) regulatory agent. Lomitapide selectively inhibits IgE/Ag‐ or phorbol 12‐myristate 13‐acetate (PMA)/ionomycin‐mediated MC degranulation by altering plasma membrane dynamics, including endocytosis and membrane fusion. ABSTRACT Allergic diseases are a global health concern, and new
Shiori Mamorita, Atsushi Furukawa, Yuka Nagata, Ryo Suzuki   +3 more
wiley   +1 more source

iCARDIO Alliance Global Implementation Guidelines for the Management of Obesity 2025

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 1, February 2026.
ABSTRACT There are a number of guidelines on how to manage obesity, but inconsistencies in healthcare access, varying infrastructure, resource constraints and diverse local practices restrict their global applicability. This underscores the need for universal recommendations that address the unique challenges faced by patients and healthcare providers ...
Stefan D. Anker, Linong Ji, Tammy Kindel, Andrew J. S. Coats, Dike Ojji, Adriana Puente Barragán, Peter Rossing, Shelley Zieroth, Shaaf Ahmad, Shariq Usman, Geeta Appannah, Alison L. Bailey, Ahmed Bennis, Andrea Brandao, Javed Butler, Melanie J. Davies, Lubomira Fabryova, Yuan‐Lin Guo, Hidetaka Itoh, Uday M. Jadhav, Carel W. Le Roux, Fausto J. Pinto, Julio Rosenstock, Banshi Saboo, Hani Sabbour, Mangesh Tiwaskar, Karol E. Watson, Kwang Wei Tham, Fernando Stuardo Wyss, Walter P. Abhayaratna, William T. Abraham, Wael Al Mahmeed, Alessia Argirò, John J. Atherton, Danielle Belardo, Raquel Campuzano, Nandini Chatterjee, Marc‐André Cornier, Sarah Davies, Clemencia de Rueda Panadero, Anastase Dzudie, Ty J. Gluckman, Muhammad Shahzeb Khan, Kamlesh Khunti, Yuri Lopatin, Zhiyi Ma, Okechukwu S. Ogah, Abraham Oomman, Emilio S. Peralta Lopez, Ping Li, Paul Poirier, Julie Redfern, Giuseppe M. C. Rosano, Donna Ryan, Amit Saraf, Sameh Shaheen, Subodh Verma, Stephan von Haehling, Martha Gulati, Naveed Sattar, Jose Luis Zamorano   +60 more
wiley   +1 more source

Identification of Potential Therapeutic Agents for Primary Amebic Meningoencephalitis Using Text Mining and Bioinformatics Analyses

Analytical Cellular Pathology, Volume 2026, Issue 1, 2026.
Naegleria fowleri, the brain‐eating ameba, causes primary amebic meningoencephalitis (PAM), a fatal infectious disease that affects the central nervous system (CNS). We aimed to evaluate the functions and potential drugs targeting PAM using text mining and bioinformatics analyses.
Eun Jung Sohn, Hyeonseo Jo, Kun Taek Park, Andrey Elchaninov   +3 more
wiley   +1 more source

Sites of glucose transporter-4 vesicle fusion with the plasma membrane correlate spatially with microtubules.

PLoS ONE, 2012
In adipocytes, vesicles containing glucose transporter-4 (GLUT4) redistribute from intracellular stores to the cell periphery in response to insulin stimulation.
Jennine M Dawicki-McKenna, Yale E Goldman, E Michael Ostap   +2 more
doaj   +1 more source

IRAP Endosomes Control Phagosomal Maturation in Dendritic Cells

Frontiers in Cell and Developmental Biology, 2020
Dendritic cells (DCs) contribute to the immune surveillance by sampling their environment through phagocytosis and endocytosis. We have previously reported that, rapidly following uptake of extracellular antigen into phagosomes or endosomes in DCs, a ...
Mirjana Weimershaus, François-Xavier Mauvais, Irini Evnouchidou, Irini Evnouchidou, Myriam Lawand, Loredana Saveanu, Peter van Endert   +6 more
doaj   +1 more source

Early Nutritional Programing: Unlocking the Potential of Fish for Sustainable Aquaculture

Aquaculture Nutrition, Volume 2026, Issue 1, 2026.
Nutritional programing, which explores the link between early nutritional conditions and their long‐term effects on animals, is a developing field within fish biology. Suboptimal nutritional status during early life is strongly associated with a higher risk of metabolic consequences later in life, including permanent growth retardation, impaired neural
Shivendra Kumar, Aditi Banik, Maneesh Kumar Dubey, Prem Prakash Srivastava, Zsuzsanna J. Sandor, Jianguang Qin   +5 more
wiley   +1 more source

Is There an Interplay Between the Functional Domains of IRAP?

Frontiers in Cell and Developmental Biology, 2020
As a member of the M1 family of aminopeptidases, insulin regulated aminopeptidase (IRAP) is characterized by distinct binding motifs at the active site in the C-terminal domain that mediate the catalysis of peptide substrates.
Anika Vear, Tracey Gaspari, Philip Thompson, Siew Yeen Chai   +3 more
doaj   +1 more source