Results 91 to 100 of about 4,083 (158)

Grape Exosome–Like Nanovesicles Reverse the Prediabetic State in Mice

Journal of Diabetes Research, Volume 2026, Issue 1, 2026.
Objective This research explored the effect of grape exosome–like nanovesicles (GELNs) on reversing prediabetic conditions in mice and investigated the underlying mechanisms via metabolomic and gut microbiota analyses. Methods Twenty‐four C57BL/6J mice were divided into four groups: normal control, prediabetic model, GELN intervention, and nutrient ...
Zao-Ling Liu, Shu-Ya Cai, Aerna Qiayimaerdan, Zulipia Zunon, Ya-Le Yu, Xiao-Die Ma, Hannah Wesley   +6 more
wiley   +1 more source

Ligand-induced conformational change of Insulin-regulated aminopeptidase: insights on catalytic mechanism and active site plasticity

, 2017
Insulin-regulated aminopeptidase (IRAP) is an enzyme with several important biological functions that is known to process a large variety of different peptidic substrates although the mechanism behind this wide specificity is not clearly understood.
Giastas, P, Kokkala, P, Georgiadis, Dimitris, Anastasia Mpakali, Georgiadis, D, Karl Harlos, Zhao, Y, Mpakali, A, Giastas, Petros, Paraskevi Kokkala, Harlos, Karl, Yuguang Zhao, Dimitris Georgiadis, Emmanuel Saridakis, Kokkala, Paraskevi, Athanasios Papakyriakou, Petros Giastas, Papakyriakou, Athanasios, Stratikos, Efstratios, Papakyriakou, A, Harlos, K, Saridakis, E, Efstratios Stratikos, Zhao, Yuguang, Mpakali, Anastasia, Saridakis, Emmanuel, Stratikos, E   +26 more
core   +1 more source

Trafficking Kinetics of the Insulin-Regulated Membrane Aminopeptidase in 3T3-L1 Adipocytes

Biochemical and Biophysical Research Communications, 1997
In fat and muscle cells insulin causes the marked translocation of the glucose transporter GLUT4 from its intracellular location to the plasma membrane. We and others have discovered an insulin-regulated membrane aminopeptidase (designated IRAP) that colocalizes with intracellular GLUT4 and also translocates markedly in response to insulin.
S A, Ross, J J, Herbst, S R, Keller, G E, Lienhard   +3 more
openaire   +2 more sources

Angiotensin II type 1 receptor blocker losartan prevents and rescues cerebrovascular, neuropathological and cognitive deficits in an Alzheimer’s disease model

Neurobiology of Disease, 2014
Angiotensin II (AngII) receptor blockers that bind selectively AngII type 1 (AT1) receptors may protect from Alzheimer’s disease (AD). We studied the ability of the AT1 receptor antagonist losartan to cure or prevent AD hallmarks in aged (~18 months at ...
Brice Ongali, Nektaria Nicolakakis, Xin-Kang Tong, Tahar Aboulkassim, Panayiota Papadopoulos, Pedro Rosa-Neto, Clotilde Lecrux, Hans Imboden, Edith Hamel   +8 more
doaj   +1 more source

[H-3]IVDE77, a novel radioligand with high affinity and selectivity for the insulin-regulated aminopeptidase

, 2013
The hexapeptide angiotensin IV (Ang IV) induces diverse biological effects such as memory enhancement and protection against ischemic stroke. Studies on the mechanism of Ang IV however are hampered by its instability and its lack of selectivity. The high-
Tourwé, Dirk, Vanderheyden, Patrick M. L., Van Den Eynde, Isabelle, Tóth, Géza, Vauquelin, Georges, Nikolaou, Alexandros, Mallareddy, Jayapal Reddy   +6 more
core   +1 more source

The effect of insulin resistance on amygdale glucose metabolism alterations in experimental Alzheimer’s disease

Бюллетень сибирской медицины, 2018
Purpose. Glucose metabolism is tightly regulated in the brain. Aberrant glucose metabolism is an important feature of neurodegenerative diseases, as inAlzheimer’s disease.
Ya. V. Gorina, Yu. K. Komleva, O. L. Lopatina, A. I. Chernykh, A. B. Salmina   +4 more
doaj   +1 more source

Inhibitors Targeting Insulin-Regulated Aminopeptidase (IRAP) : Identification, Synthesis and Evaluation

, 2020
Insulin-regulated aminopeptidase (IRAP) has emerged as a potential new therapeutic target for treatment of cognitive disorders. Inhibition of the enzymatic activity facilitates cognition in rodents.
Engen, Karin
core  

Regulation of Insulin-Regulated Membrane Aminopeptidase Activity by Its C-Terminal Domain

, 2016
The development of inhibitors of insulin-regulated aminopeptidase (IRAP), a membrane-bound zinc metallopeptidase, is a promising approach for the discovery of drugs for the treatment of memory loss such as that associated with Alzheimer’s disease.
Brett A. Cromer (1703428), Robert A. Cherny (31159), Irene Volitakis (31156), Siew Yeen Chai (2213875), Michael W. Parker (322267), David B. Ascher (1358214), Craig J. Morton (1792909), Anthony L. Albiston (2213878)   +7 more
core   +1 more source

Potent Macrocyclic Inhibitors of Insulin-Regulated Aminopeptidase (IRAP) by Olefin Ring-Closing Metathesis

, 2011
Macrocyclic analogues of angiotensin IV (Ang IV, Val1-Tyr2-Ile3-His4-Pro5-Phe6) targeting the insulin-regulated aminopeptidase (IRAP) have been designed, synthesized, and evaluated biologically.
Karlén, Anders,, Lindeberg, Gunnar,, Anders Hallberg, Hallberg, Mathias,, Heidi Demaegdt, Erdélyi, Máté,, Anders Johnsson, Georges Vauquelin, Hallberg, Anders,, Gunnar Lindeberg, Johnsson, Anders,, Andersson, Hanna,, Hanna Andersson, Vauquelin, Georges,, Mathias Hallberg, Máté Erdélyi, Anders Karlén, Demaegdt, Heidi,   +17 more
core   +1 more source

Potent Macrocyclic Inhibitors of Insulin-Regulated Aminopeptidase (IRAP) by Olefin Ring-Closing Metathesis

, 2016
Macrocyclic analogues of angiotensin IV (Ang IV, Val1-Tyr2-Ile3-His4-Pro5-Phe6) targeting the insulin-regulated aminopeptidase (IRAP) have been designed, synthesized, and evaluated biologically.
Hanna Andersson (1408987), Mathias Hallberg (1656958), Anders Karlén (1281249), Gunnar Lindeberg (492163), Anders Johnsson (2193301), Anders Hallberg (585061), Heidi Demaegdt (470499), Georges Vauquelin (2136157), Máté Erdélyi (1364241)   +8 more
core   +1 more source