Results 111 to 120 of about 4,083 (158)

Synthesis of Insulin-Regulated Aminopeptidase (IRAP) inhibitors

, 2015
The need for alternative cognitive enhancers has risen due to the fact that clinical trial results of the drugs currently approved for treating these disorders have not been satisfactory. IRAP has become a possible drug target for treating cognitive impairment brought about by Alzheimer’s disease, head trauma or cerebral ischemia, among others.
openaire   +1 more source

Molecular characterization of insulin-regulated aminopeptidase (IRAP)

, 2006
© 2006 Dr. Siying YeCentral infusion of the hexapeptide angiotensin IV (Ang IV) and its analogs have been demonstrated to markedly enhance memory retention and retrieval in rats using a range of learning and memory paradigms.
Ye, Siying
core  

Insulin-Regulated Aminopeptidase in Women with Breast Cancer: A Role beyond the Regulation of Oxytocin and Vasopressin. [PDF]

Cancers (Basel), 2020
Ramírez-Expósito MJ, Dueñas-Rodríguez B, Carrera-González MP, Navarro-Cecilia J, Martínez-Martos JM.   +4 more
europepmc   +1 more source

Angiotensin AT4 ligands are potent, competitive inhibitors of insulin regulated aminopeptidase (IRAP)

, 2003
Angiotensin IV (Ang IV) exerts profound effects on memory and learning, a phenomenon ascribed to its binding to a specific AT4 receptor. However the AT4 receptor has recently been identified as the insulin-regulated aminopeptidase (IRAP).
Siying Ye (13094898), R Lew (13471534), S Chai (9882683), T Mustafa (13733881), S McDowall (13733884), A Albiston (13732981)   +5 more
core  

Novel macrocyclic peptidomimetics targeting the insulin-regulated aminopeptidase (IRAP): design, synthesis and evaluation. [PDF]

RSC Med Chem
Olaniran Håkansson E, Balestri LJI, Puthiyaparambath S, Moes S, Henschel H, Sköld C, Hallberg M, Larhed M, Skillinghaug B, Odell LR.   +9 more
europepmc   +1 more source

Insulin-regulated aminopeptidase deficiency impairs cardiovascular adaptations and placental development during pregnancy. [PDF]

Clin Sci (Lond), 2020
Walton SL, Mirabito Colafella KM, Ansari A, Chai SY, Denton KM.   +4 more
europepmc   +1 more source

Insulin-regulated aminopeptidase inhibitor C9 restores cellular activity in methadone-damaged primary cell cultures

Insulin-regulated aminopeptidase (IRAP) is emerging as a pharmaceutical target for treatment of neurotoxic- and neurodegenerative symptoms commonly seen in cognitive impairments.
Stam, Frida, Olaniran Håkansson, Esther, Lind, Sara Florén, Grönbladh, Alfhild, Larhed, Mats, Hallberg, Mathias, Nylander, Erik, Odell, Luke R., Gising, Johan   +8 more
core   +1 more source

Quantum Mechanics/Molecular Mechanics Simulations Distinguish Insulin-Regulated Aminopeptidase Substrate (Oxytocin) and Inhibitor (Angiotensin IV) and Reveal Determinants of Activity and Inhibition. [PDF]

J Chem Inf Model
Hanževački M, Twidale RM, Lang EJM, Gerrard W, Wright DW, Stojevic V, Mulholland AJ.   +6 more
europepmc   +1 more source

Electroosmotic Perfusion-Microdialysis Probe Created by Direct Laser Writing for Quantitative Assessment of Leucine Enkephalin Hydrolysis by Insulin-Regulated Aminopeptidase in Vivo. [PDF]

Anal Chem, 2020
Wilson RE, Jaquins-Gerstl A, Chen J, Rerick M, Weber SG.   +4 more
europepmc   +1 more source

Stabilization of the open conformation οf insulin-regulated aminopeptidase by a novel substrate-selective small-molecule inhibitor. [PDF]

Protein Sci
Mpakali A, Georgaki G, Buson A, Findlay AD, Foot JS, Mauvais FX, van Endert P, Giastas P, Hamprecht DW, Stratikos E.   +9 more
europepmc   +1 more source