Results 41 to 50 of about 4,083 (158)

Trans-Modulation of the Somatostatin Type 2A Receptor Trafficking by Insulin-Regulated Aminopeptidase Decreases Limbic Seizures. [PDF]

J Neurosci, 2015
Within the hippocampus, the major somatostatin (SRIF) receptor subtype, the sst2A receptor, is localized at postsynaptic sites of the principal neurons where it modulates neuronal activity.
De Bundel D, Fafouri A, Csaba Z, Loyens E, Lebon S, El Ghouzzi V, Peineau S, Vodjdani G, Kiagiadaki F, Aourz N, Coppens J, Walrave L, Portelli J, Vanderheyden P, Chai SY, Thermos K, Bernard V, Collingridge G, Auvin S, Gressens P, Smolders I, Dournaud P.   +21 more
europepmc   +2 more sources

IRAP Inhibitors: M1-Aminopeptidase Family Inspiration

Frontiers in Pharmacology, 2020
The insulin regulated aminopeptidase (IRAP) has been proposed as an important therapeutic target for indications including Alzheimer’s disease and immune disorders.
Nicholas Barlow, Philip E. Thompson
doaj   +1 more source

Inhibition of Insulin-Regulated Aminopeptidase: A Novel Therapeutic Strategy for Stroke

, 2022
This thesis characterises and validates a preclinical model of stroke that closely mimics human stroke. In this preclinical model, novel drug therapies that target the insulin-regulated aminopeptidase (IRAP), an enzyme found in the brain, were tested ...
JONATHON TELIANIDIS (14071242)
core   +1 more source

Hydrogen Peroxide Induced Toxicity Is Reversed by the Macrocyclic IRAP-Inhibitor HA08 in Primary Hippocampal Cell Cultures

Current Issues in Molecular Biology, 2022
Angiotensin IV (Ang IV), a metabolite of Angiotensin II, is a bioactive hexapeptide that inhibits the insulin-regulated aminopeptidase (IRAP). This transmembrane zinc metallopeptidase with many biological functions has in recent years emerged as a new ...
Frida Stam, Sara Florén Lind, Anja Schroff, Sofia Zelleroth, Erik Nylander, Johan Gising, Alfhild Grönbladh, Mats Larhed, Mathias Hallberg   +8 more
doaj   +1 more source

Negative regulation of syntaxin4/SNAP-23/VAMP2-mediated membrane fusion by Munc18c In Vitro [PDF]

, 2008
Background: Translocation of the facilitative glucose transporter GLUT4 from an intracellular store to the plasma membrane is responsible for the increased rate of glucose transport into fat and muscle cells in response to insulin.
Nia J Bryant, Gould, G.W., Veronica Aran, James A McNew, Gwyn W Gould, McNew, J.A., Bryant, N.J., Aran Veronica, Avani Verma, Gould Gwyn W., Aran-Ponte, V., Fiona M Brandie, Bryant Nia J., Verma Avani, Brandie Fiona M., McNew James A., Brandie, F.M., Verma, A.   +17 more
core   +1 more source

Pleiotropic effects of Syntaxin16 identified by gene editing in cultured adipocytes

Frontiers in Cell and Developmental Biology, 2022
Adipocytes play multiple roles in the regulation of glucose metabolism which rely on the regulation of membrane traffic. These include secretion of adipokines and serving as an energy store.
Shaun K. Bremner, Woroud S. Al Shammari, Roderick S. Milligan, Brian D. Hudson, Calum Sutherland, Nia J. Bryant, Gwyn W. Gould   +6 more
doaj   +1 more source

Translocation of the insulin-regulated aminopeptidase to the cell surface: detection by radioligand binding. [PDF]

Br J Pharmacol, 2008
Background and purpose:Insulin‐regulated aminopeptidase (IRAP) and the insulin‐dependent glucose transporter GLUT4 colocalize in specific intracellular vesicles (that is, GLUT4 vesicles). These vesicles move slowly to the cell surface, but their translocation is markedly enhanced by insulin, resulting in higher glucose uptake.
Demaegdt H, Smitz L, De Backer JP, Le MT, Bauwens M, Szemenyei E, Tóth G, Michotte Y, Vanderheyden P, Vauquelin G.   +9 more
europepmc   +4 more sources

Crystal structure of human insulin-regulated aminopeptidase with specificity for cyclic peptides. [PDF]

Protein Sci, 2015
AbstractInsulin‐regulated aminopeptidase (IRAP or oxytocinase) is a membrane‐bound zinc‐metallopeptidase that cleaves neuroactive peptides in the brain and produces memory enhancing effects when inhibited. We have determined the crystal structure of human IRAP revealing a closed, four domain arrangement with a large, mostly buried cavity abutting the ...
Hermans SJ, Ascher DB, Hancock NC, Holien JK, Michell BJ, Chai SY, Morton CJ, Parker MW.   +7 more
europepmc   +6 more sources

Characterization of the Insulin-regulated Membrane Aminopeptidase in 3T3-L1 Adipocytes [PDF]

Journal of Biological Chemistry, 1996
A novel membrane aminopeptidase has been identified as a major protein in vesicles from rat adipocytes containing the glucose transporter isotype Glut4. In this study we have characterized this aminopeptidase, referred to as vp165, in 3T3-L1 adipocytes. The subcellular distributions of vp165 and Glut4 were determined by immunoisolation of vesicles with
S A, Ross, H M, Scott, N J, Morris, W Y, Leung, F, Mao, G E, Lienhard, S R, Keller   +6 more
openaire   +2 more sources

Insulin-regulated aminopeptidase in adipocyte is Cys-specific and affected by obesity [PDF]

Journal of Molecular Endocrinology, 2015
Insulin-regulated aminopeptidase (IRAP, EC 3.4.11.3) in adipocytes is well known to traffic between high (HDM) and low (LDM) density microsomal fractions toward the plasma membrane (MF) under stimulation by insulin. However, its catalytic preference for aminoacyl substrates with N-terminal Leu or Cys is controversial.
Rafaela Fadoni, Alponti, Luciana Godoy, Viana, Norma, Yamanouye, Paulo Flavio, Silveira   +3 more
openaire   +2 more sources