Results 51 to 60 of about 4,083 (158)

The Type of Fat in the Diet Influences the Behavior and the Relationship Between Cystinyl and Alanyl Aminopeptidase Activities in Frontal Cortex, Liver, and Plasma

Frontiers in Molecular Biosciences, 2020
Insulin-regulated aminopeptidase (IRAP, cystinyl aminopeptidase, CysAP) and aminopeptidase M (alanyl aminopeptidase, AlaAP) are closely related enzymes involved in cognitive, metabolic, and cardiovascular functions.
Ana Belén Segarra, Isabel Prieto, Inmaculada Banegas, Magdalena Martínez-Cañamero, Marc de Gasparo, Patrick Vanderheyden, Stefan Zorad, Manuel Ramírez-Sánchez   +7 more
doaj   +1 more source

Local renin angiotensin system and sperm DNA fragmentation

Asian Journal of Andrology, 2022
The renin angiotensin system (RAS) appears to influence male fertility at multiple levels. In this work, we analyzed the relationship between the RAS and DNA integrity.
María Victoria Aparicio Prieto, María Victoria Rodríguez Gallego, Asier Valdivia Palacín, Yosu Franco Iriarte, Gotzone Hervás Barbara, Enrique Echevarría Orella, Luis Casis Saenz   +6 more
doaj   +1 more source

Intrathecal injections of non-peptide oxytocin receptor agonists, WAY 267,464 and TC OT 39, induce significant anti-hyperalgesia in both male and female rats with inflammatory pain [PDF]

Iranian Journal of Basic Medical Sciences
Objective(s): Hyperalgesia is a clinical condition related to chronic pain in which patients experience increased nociceptive sensitivity. Intrathecal oxytocin has been shown to induce significant anti-hyperalgesia in both rodents and humans. However, in
Lok-Hi Chow, Yuan-Hao Chen, Ying-Jie Chen, Pin-Chen Lin, Eagle Yi-Kung Huang   +4 more
doaj   +1 more source

Characterization of the role of the Rab GTPase-activating protein AS160 in insulin-regulated GLUT4 trafficking [PDF]

, 2005
Insulin stimulates the translocation of the glucose transporter GLUT4 from intracellular vesicles to the plasma membrane. In the present study we have conducted a comprehensive proteomic analysis of affinity-purified GLUT4 vesicles from 3T3-L1 adipocytes
James, David E., Stockli, Jacqueline, Winata, Stephanie, Graham, Michael, Larance, Mark, Wasinger, Valerie, van Dam, Ellen M., Guilhaus, Michael, Simpson, Fiona, Ramm, Georg, Junutula, Jagath R.   +10 more
core   +1 more source

Insulin-regulated aminopeptidase inhibitors do not alter glucose handling in normal and diabetic rats

, 2017
Insulin-regulated aminopeptidase (IRAP) co-localizes with the glucose transporter 4 (GLUT4) in GLUT4 storage vesicles (GSV) in insulin-responsive cells.
Cacador, M, Anthony L Albiston, Chai, Siew Yeen, Siew Yeen Chai, Albiston, Anthony, Burns, P, Peta Burns, Sinnayah, Puspha, Burns, Peta, Puspha Sinnayah, Mauricio Cacador, Cacador, Mauricio, Chai, SY   +12 more
core   +1 more source

Insulin and glucose play a role in foam cell formation and function

Cardiovascular Diabetology, 2006
Background Foam cell formation in diabetic patients often occurs in the presence of high insulin and glucose levels. To test whether hyperinsulinemic hyperglycemic conditions affect foam cell differentiation, we examined gene expression, cytokine ...
Keller Susanna R, Huo Yuqing, Rissing Benjamin A, Miller Yury I, Jain Nitin, Shashkin Pavel N, Vandenhoff George E, Nadler Jerry L, McIntyre Thomas M   +8 more
doaj   +1 more source

Mast cell-mediated inflammation relies on insulin-regulated aminopeptidase controlling cytokine export from the Golgi

, 2023
International audienceBackground: Upon activation, mast cells rapidly release preformed inflammatory mediators from large cytoplasmic granules via regulated exocytosis.
Carvalho, Caroline, Weimershaus, Mirjana, van Endert, Peter, Maciel, Thiago Trovati, Rignault, Rachel, Waeckel-Enee, Emmanuelle, Dussiot, Michael, Hermine, Olivier   +7 more
core   +1 more source

Anti-Inflammatory and Antitumor Effects of Hydroxytyrosol but Not Oleuropein on Experimental Glioma In Vivo. A Putative Role for the Renin-Angiotensin System

Biomedicines, 2018
Functional roles of the angiotensin peptides of the renin-angiotensin system (RAS) cascade can be analyzed through their corresponding proteolytic regulatory enzymes aspartyl aminopeptidase (ASAP), aminopeptidase A (APA), aminopeptidase B (APB ...
María Jesús Ramírez-Expósito, José Manuel Martínez-Martos   +1 more
doaj   +1 more source

The emerging multifunctional roles of ERAP1, ERAP2 and IRAP between antigen processing and renin-angiotensin system modulation

Frontiers in Immunology, 2022
The Endoplasmic Reticulum Aminopeptidase 1 and 2 (ERAP1 and ERAP2) and Insulin Regulated Aminopeptidase (IRAP) are three M1 zinc metalloproteases whose role in antigen processing is the refining of peptidome either in the Endoplasmic reticulum (ERAP1 and
Benedetta Mattorre, Valentina Tedeschi, Giorgia Paldino, Maria Teresa Fiorillo, Fabiana Paladini, Rosa Sorrentino   +5 more
doaj   +1 more source

Serum IRAP, a Novel Direct Biomarker of Prediabetes and Type 2 Diabetes?

Frontiers in Molecular Biosciences, 2021
Insulin resistance (IR), currently called prediabetes (PD), affects more than half of the adult population worldwide. Type 2 diabetes (T2D), which often follows in the absence of treatment, affects more than 475 million people and represents 10–20% of ...
Candice Trocmé, Nicolas Gonnet, Margaux Di Tommaso, Hanen Samouda, Jean-Luc Cracowski, Jean-Luc Cracowski, Jean-Luc Cracowski, Claire Cracowski, Stéphanie Lambert-Porcheron, Stéphanie Lambert-Porcheron, Martine Laville, Martine Laville, Martine Laville, Estelle Nobécourt, Chiraz Gaddhab, Allan Le Lay, Torsten Bohn, Christine Poitou, Christine Poitou, Karine Clément, Karine Clément, Fahd Al-Mulla, Milad S. Bitar, Milad S. Bitar, Serge P. Bottari, Serge P. Bottari, Serge P. Bottari, Serge P. Bottari   +27 more
doaj   +1 more source