Insulin resistance and insulin sensitizing agents. [PDF]
Metabolism, 2021 Insulin resistance is a common feature of obesity and type 2 diabetes, but novel approaches of diabetes subtyping (clustering) revealed variable degrees of insulin resistance in people with diabetes. Specifically, the severe insulin resistant diabetes (SIRD) subtype not only exhibits metabolic abnormalities, but also bears a higher risk for ...
Lucia Mastrototaro, M. Roden
semanticscholar +3 more sources
Insulin resistance in patients with schizophrenia: is it related to gut permeability? [PDF]
Schizophrenia (Heidelb)Couce-Sánchez M +6 more
europepmc +3 more sources
Pathophysiology of Prediabetes Hyperinsulinemia and Insulin Resistance in the Cardiovascular System [PDF]
BiomedicinesHyperinsulinemia refers to an elevated level of circulating insulin (80 and 100 µU/mL), often leading to metabolic disorders such as obesity, insulin resistance, and type 2 diabetes (T2D).
Ghassan Bkaily +3 more
doaj +2 more sources
Use of the SGLT2 inhibitor canagliflozin for control of refractory equine hyperinsulinemia and laminitis [PDF]
Open Veterinary Journal, 2022 Background: Hyperinsulinemia associated with pituitary pars intermedia dysfunction (PPID) and/or equine metabolic syndrome (EMS) is well documented to put horses at high risk of laminitis.
Eleanor M. Kellon, Kathleen M. Gustafson
doaj +1 more source
Hypertriglyceridemia in equines with refractory hyperinsulinemia treated with SGLT2 inhibitors
Open Veterinary Journal, 2023 Background: Sodium-Glucose CoTransporter-2 [SGLT2] inhibitors, the -flozin group of drugs, which block glucose reuptake in the renal proximal tubule, are being increasingly used off-label to treat horses with refractory hyperinsulinemia. After two years
Eleanor M. Kellon, Kathleen M. Gustafson
doaj +1 more source
Possible dysmetabolic hyperferritinemia in hyperinsulinemic horses [PDF]
Open Veterinary Journal, 2019 Background: Hyperinsulinemia associated with equine metabolic syndrome (EMS) and pituitary pars intermedia dysfunction (PPID) is a risk factor for laminitis.
Eleanor M. Kellon, Kathleen M. Gustafson
doaj +1 more source
Gut microbial carbohydrate metabolism contributes to insulin resistance
Nature, 2023 Faecal carbohydrates, particularly host-accessible monosaccharides, are increased in individuals with insulin resistance and are associated with microbial carbohydrate metabolisms and host inflammatory cytokines.
T. Takeuchi +24 more
semanticscholar +1 more source
Insulin resistance and cardiovascular disease
Journal of International Medical Research, 2023 Insulin resistance (IR) and cardiovascular disease (CVD) represent two universal public health hazards, especially in today’s Western societies. A causal-effect relationship has been established that links IR with CVD.
C. E. Kosmas +5 more
semanticscholar +1 more source
Trends in insulin resistance: insights into mechanisms and therapeutic strategy
Signal Transduction and Targeted Therapy, 2022 The centenary of insulin discovery represents an important opportunity to transform diabetes from a fatal diagnosis into a medically manageable chronic condition.
Mengwei Li +5 more
semanticscholar +1 more source
Insulin Resistance: From Mechanisms to Therapeutic Strategies
Diabetes & Metabolism Journal, 2021 Insulin resistance is the pivotal pathogenic component of many metabolic diseases, including type 2 diabetes mellitus, and is defined as a state of reduced responsiveness of insulin-targeting tissues to physiological levels of insulin.
Shin-Hae Lee, Shi-Young Park, C. Choi
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