A small amount of dietary carbohydrate can promote the HFD-induced insulin resistance to a maximal level. [PDF]
PLoS ONE, 2014 Both dietary fat and carbohydrates (Carbs) may play important roles in the development of insulin resistance. The main goal of this study was to further define the roles for fat and dietary carbs in insulin resistance.
Shuang Mei +10 more
doaj +1 more source
Regulation of Insulin Clearance by Non-Esterified Fatty Acids
Biomedicines, 2022 Insulin stores lipid in adipocytes and prevents lipolysis and the release of non-esterified fatty acids (NEFA). Excessive release of NEFA during sustained energy supply and increase in abdominal adiposity trigger systemic insulin resistance, including in
Sonia M. Najjar +8 more
doaj +1 more source
Mangosteen Extract Shows a Potent Insulin Sensitizing Effect in Obese Female Patients: A Prospective Randomized Controlled Pilot Study. [PDF]
, 2018 There is a widely acknowledged association between insulin resistance and obesity/type 2 diabetes (T2DM), and insulin sensitizing treatments have proved effective in preventing diabetes and inducing weight loss.
Addessi, E +11 more
core +2 more sources
Insulin resistance and insulin sensitizing agents [PDF]
Metabolism, 2021 Insulin resistance is a common feature of obesity and type 2 diabetes, but novel approaches of diabetes subtyping (clustering) revealed variable degrees of insulin resistance in people with diabetes. Specifically, the severe insulin resistant diabetes (SIRD) subtype not only exhibits metabolic abnormalities, but also bears a higher risk for ...
Lucia, Mastrototaro, Michael, Roden
openaire +2 more sources
Is acetylation a metabolic rheostat that regulates skeletal muscle insulin action? [PDF]
, 2015 Skeletal muscle insulin resistance, which increases the risk for developing various metabolic diseases, including type 2 diabetes, is a common metabolic disorder in obesity and aging.
LaBarge, Samuel +2 more
core +2 more sources
Class III PI3K regulates organismal glucose homeostasis by providing negative feedback on hepatic insulin signalling. [PDF]
, 2015 Defective hepatic insulin receptor (IR) signalling is a pathogenic manifestation of metabolic disorders including obesity and diabetes. The endo/lysosomal trafficking system may coordinate insulin action and nutrient homeostasis by endocytosis of IR and ...
Burnol, Anne-Françoise +7 more
core +1 more source
Changes in insulin sensitivity over time and associated factors in HIV-infected adolescents [PDF]
, 2018 OBJECTIVE: To compare prevalence of insulin resistance between perinatally HIV-infected (PHIV+) and perinatally HIV-exposed, but uninfected adolescents (PHEU), determine incidence of and contributory factors to new and resolved cases of insulin ...
Dimeglio, Linda A. +13 more
core +1 more source
Recurrent insulin resistance [PDF]
Postgraduate Medical Journal, 1980 Summary The patient described developed 2 separate episodes of insulin resistance and on each occassion daily administration of soluble insulin in a daily dose of 980 units failed to achieve satisfactory control. Both episodes responded to steroid therapy.
B A, Leatherdale, D A, Ingram, K, Dixon
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Divergences in insulin resistance between the different phenotypes of the polycystic ovary syndrome [PDF]
, 2013 Context/Objective: Current diagnostic criteria for polycystic ovary syndrome (PCOS) have generated distinct PCOS phenotypes, based on the different combinations of diagnostic features found in each patient.
Bonin, Cecilia +12 more
core +1 more source