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Post-operative insulin resistance
Post-operative insulin resistance (IR) is a recognised marker of surgical stress. However, the reasons underlying post-operative IR and its clinical value are still unclear.
Irina Aleksandrovna Tarasova+2 more
doaj +1 more source
Class III PI3K regulates organismal glucose homeostasis by providing negative feedback on hepatic insulin signalling. [PDF]
Defective hepatic insulin receptor (IR) signalling is a pathogenic manifestation of metabolic disorders including obesity and diabetes. The endo/lysosomal trafficking system may coordinate insulin action and nutrient homeostasis by endocytosis of IR and ...
Burnol, Anne-Françoise+7 more
core +1 more source
Nutritional modulation of insulin resistance [PDF]
Insulin resistance has been proposed as the strongest single predictor for the development of Type 2 Diabetes (T2DM). Chronic oversupply of energy from food, together with inadequate physical activity, have been recognized as the most relevant factors ...
Weickert, Martin O.
core +3 more sources
TLR4 links innate immunity and fatty acid-induced insulin resistance.
TLR4 is the receptor for LPS and plays a critical role in innate immunity. Stimulation of TLR4 activates proinflammatory pathways and induces cytokine expression in a variety of cell types.
Hang Shi+5 more
semanticscholar +1 more source
Hyperinsulinemia and insulin resistance : What comes first ? [PDF]
Background 1) Classical explanation : Classical explanation of diabetic pathophysiology states that obesity induced insulin resistance develops first and is followed by compensatory hyperinsulinnemia.
Milind M. Watve, Pramod P. Patil
core +2 more sources
The prevalence of sarcopenic obesity is increasing worldwide, particularly amongst aging populations. Insulin resistance is the core mechanism of sarcopenic obesity and is also associated with variable cardiometabolic diseases such as cardiovascular ...
So-hyeon Hong, K. Choi
semanticscholar +1 more source
Divergences in insulin resistance between the different phenotypes of the polycystic ovary syndrome [PDF]
Context/Objective: Current diagnostic criteria for polycystic ovary syndrome (PCOS) have generated distinct PCOS phenotypes, based on the different combinations of diagnostic features found in each patient.
Bonin, Cecilia+12 more
core +1 more source
Chemerin receptor blockade improves vascular function in diabetic obese mice via redox-sensitive- and Akt-dependent pathways [PDF]
Chemerin and its G protein-coupled receptor [chemerin receptor 23 (ChemR23)] have been associated with endothelial dysfunction, inflammation, and insulin resistance.
Alves-Lopes, Rheure+9 more
core +1 more source
Fructose and hepatic insulin resistance
Excessive caloric intake in a form of high-fat diet (HFD) was long thought to be the major risk factor for development of obesity and its complications, such as fatty liver disease and insulin resistance.
S. Softic+8 more
semanticscholar +1 more source
Inflammation and insulin resistance [PDF]
Over a hundred years ago, high doses of salicylates were shown to lower glucose levels in diabetic patients. This should have been an important clue to link inflammation to the pathogenesis of type 2 diabetes (T2D), but the antihyperglycemic and antiinflammatory effects of salicylates were not connected to the pathogenesis of insulin resistance until ...
Allison B. Goldfine+2 more
openaire +4 more sources