Results 61 to 70 of about 797,794 (382)
Cellular & Molecular Biology LettersBackground The trafficking of cargoes from endosomes to the trans-Golgi network requires numerous sequential and coordinated steps. Cargoes are sorted into endosomal-derived carriers that are transported, tethered, and fused to the trans-Golgi network ...
Jérôme Gilleron +4 more
doaj +1 more source
Zero-inflated Poisson Factor Model with Application to Microbiome Absolute Abundance Data [PDF]
Biometrics. 2021 Mar;77(1):91-101, 2019 Dimension reduction of high-dimensional microbiome data facilitates subsequent analysis such as regression and clustering. Most existing reduction methods cannot fully accommodate the special features of the data such as count-valued and excessive zero reads. We propose a zero-inflated Poisson factor analysis (ZIPFA) model in this article.
arxiv +1 more source
Molecular Oncology, EarlyView.We quantified and cultured circulating tumor cells (CTCs) of 62 patients with various cancer types and generated CTC‐derived tumoroid models from two salivary gland cancer patients. Cellular liquid biopsy‐derived information enabled molecular genetic assessment of systemic disease heterogeneity and functional testing for therapy selection in both ...
Nataša Stojanović Gužvić +31 more
wiley +1 more source
Insulin signaling and its application
Frontiers in Endocrinology, 2023 The discovery of insulin in 1921 introduced a new branch of research into insulin activity and insulin resistance. Many discoveries in this field have been applied to diagnosing and treating diseases related to insulin resistance.
Thi Kim Chung Le +9 more
doaj +1 more source
Phenotypical heterogeneity linked to adipose tissue dysfunction in patients with type 2 diabetes [PDF]
, 2016 Adipose tissue (AT) inflammation leads to increased free fatty acid (FFA) efflux and ectopic fat deposition, but whether AT dysfunction drives selective fat accumulation in specific sites remains unknown.
ANGELICO, Francesco +12 more
core +1 more source
Insulin Resistance and Hypertension [PDF]
Hypertension, 2004 The association between insulin resistance and insulinemia and hypertension is controversial. We examined the relation between insulin resistance and hypertension in 564 non-Hispanic whites (NHW), 505 Hispanics (H), and 413 African Americans (AA) who participated in the Insulin Resistance Atherosclerosis Study (IRAS).
Marian Rewers +9 more
openaire +3 more sources
Molecular Oncology, EarlyView.Male infertility is a known risk factor for the development of testicular cancer. In this paper, we analyzed the expression profile of a microRNA panel by real‐time PCR and validated the results by digital PCR. Experimental and bioinformatics analyses allowed us to identify possible biomarkers able to discern men with a higher risk of developing ...
Carmen Ferrara +14 more
wiley +1 more source
Is vascular insulin resistance an early step in diet-induced whole-body insulin resistance?
Nutrition & Diabetes, 2022 There is increasing evidence that skeletal muscle microvascular (capillary) blood flow plays an important role in glucose metabolism by increasing the delivery of glucose and insulin to the myocytes.
Lauren Carmichael +8 more
doaj +1 more source
The novel adiponectin-resistin (AR) and insulin resistance (IR~AR~) indexes [PDF]
, 2010 Serum hypoadiponectinemia and hyperrestinemia independently links insulin resistance to type 2 diabetes (T2DM) and metabolic syndrome (MS). Thus, the aim of this study was propose a novel adiponectin-resistin (AR) index by unifying the effect of ...
Cia-Hin Lau, Sekaran Muniandy
core +1 more source
β-Cell failure in type 2 diabetes: a case of asking too much of too few? [PDF]
, 2013 The islet in type 2 diabetes (T2DM) is characterized by a deficit in β-cells, increased β-cell apoptosis, and extracellular amyloid deposits derived from islet amyloid polypeptide (IAPP). In the absence of longitudinal studies, it is unknown if the low β-
Butler, Peter C +4 more
core +1 more source