Results 91 to 100 of about 260,978 (210)

Interferon lambda protects the female reproductive tract against Zika virus infection

Nature Communications, 2019
Zika virus infections can cause devastating congenital birth defects but the underlying interactions with the host immune system are not well understood.
Elizabeth A. Caine, Suzanne M. Scheaffer, Nitin Arora, Konstantin Zaitsev, Maxim N. Artyomov, Carolyn B. Coyne, Kelle H. Moley, Michael S. Diamond   +7 more
doaj   +1 more source

Single‐cell RNA sequencing of peripheral blood defines two immunological subtypes of Sjögren's disease distinguished by anti‐SSA antibodies and aberrant B cell populations

Arthritis &Rheumatology, Accepted Article.
Objectives Sjögren's disease (SjD) is a heterogeneous autoimmune disorder characterized by substantial clinical and molecular diversity. This heterogeneity raises key questions regarding the existence of distinct pathogenic mechanisms underlying disease subtypes.
Geoffrey Urbanski, Kimberly E. Taylor, Emily Flynn, Armita Norouzi, Catherine Chu, Brittany Davidson, Arnab Ghosh, Joanne Nititham, Ravi K. Patel, Annie W. Poon, Gabriela K. Fragiadakis, Alexis J. Combes, Walter L. Eckalbar, Lindsey A. Criswell, Chun Jimmie Ye, Caroline H. Shiboski   +15 more
wiley   +1 more source

Equivalence of call-by-name and call-by-need for lambda-calculi with letrec [PDF]

, 2006
We develop a proof method to show that in a (deterministic) lambda calculus with letrec and equipped with contextual equivalence the call-by-name and the call-by-need evaluation are equivalent, and also that the unrestricted copy-operation is correct ...
Schmidt-Schauß, Manfred, Manfred Schmidt-Schauß   +1 more
core  

Bovine Interferon Lambda Is a Potent Antiviral Against SARS-CoV-2 Infection in vitro

Frontiers in Veterinary Science, 2020
Interferon lambda (IFN-λ) is an antiviral naturally produced in response to viral infections, with activity on cells of epithelial origin and located in the mucosal surfaces.
Nancy Patricia Cardoso, Florencia Celeste Mansilla, Estefanía Benedetti, Cecilia Soledad Turco, Lucas José Barone, Javier Alonso Iserte, Ivana Soria, Elsa Baumeister, Alejandra Victoria Capozzo   +8 more
doaj   +1 more source

Clinical relevance of pharmacogenomic information for improving prescribing practices in acutely admitted older medical patients

British Journal of Clinical Pharmacology, EarlyView.
Aims Safe prescribing and effective medication review during acute hospitalization depends on accurate information about liver and kidney function because these organs are responsible for the elimination of most medications. While estimates for kidney function are widely used, comparable markers of hepatic drug‐metabolizing capacity are not routinely ...
Louise Westberg Strejby Christensen, Anne Kirstine Boas, Emilie Clausen, Nicoline Elers Koch, Anne Byriel Walls, Lotte Stig Nørgaard, Michael Asger Andersen, Anissa Aharaz, Rikke Lundsgaard Nielsen, Olivia Bornæs, Juliette Tavenier, Baker Nawfal Jawad, Helle Gybel Juul‐Larsen, Esben Iversen, Ove Andersen, Lona Louring Christrup, Kim Peder Dalhoff, Morten Baltzer Houlind   +17 more
wiley   +1 more source

[Letter from Leadership Lambda Seminar Series to Participants, February 20, 1999]

, 1999
A one-page letter to Leadership Lambda Seminar Series Participants, 20 February 1999.
Leadership Lambda, Inc.
core   +1 more source

Lambda Calculus in Core Aldwych [PDF]

, 2016
Core Aldwych is a simple model for concurrent computation, involving the concept of agents which communicate through shared variables. Each variable will have exactly one agent that can write to it, and its value can never be changed once written, but a ...
Communicating Process Architectures, HUNTBACH, MM   +1 more
core   +2 more sources

Time‐Dependent Bias and Prognostic Confounding in Exposure–Response Analysis of Targeted Therapies: Lessons from Sunitinib in Metastatic Renal Cancer

Clinical Pharmacology &Therapeutics, EarlyView.
Exposure–response (E–R) analyses of sunitinib in metastatic renal cell carcinoma (mRCC) have supported concentration‐guided dose escalation. However, such analyses may be biased when exposure metrics incorporate post‐baseline dose modifications, time‐varying apparent clearance, or baseline factors that influence both pharmacokinetics and clinical ...
Han Liu, Lena E. Friberg
wiley   +1 more source

Simulation in the call-by-need lambda-calculus with letrec, case, constructors, and seq [PDF]

, 2012
This paper shows equivalence of applicative similarity and contextual approximation, and hence also of bisimilarity and contextual equivalence, in LR, the deterministic call-by-need lambda calculus with letrec extended by data constructors, case ...
Sabel, David, Schmidt-Schauß, Manfred, Machkasova, Elena   +2 more
core  

COL1A1+ Epithelial Cells Orchestrate VEGFA‐VEGFR Signaling in Endometritis Revealed by Single‐Cell Analysis

Journal of Clinical Laboratory Analysis, EarlyView.
Single‐cell RNA‐seq of normal and endometritis endometrium shows reduced epithelial cells and fate divergence toward ferroptosis or ribosome/antigen‐presentation programs. COL1A1+ epithelial cells act as an AP‐1–driven hub that enhances VEGFA–VEGFR signaling and remodels the vascular microenvironment.
Chengzi Tian, Zaiyi Li
wiley   +1 more source