Results 81 to 90 of about 11,209 (176)

Bovine Interferon Lambda Is a Potent Antiviral Against SARS-CoV-2 Infection in vitro

Frontiers in Veterinary Science, 2020
Interferon lambda (IFN-λ) is an antiviral naturally produced in response to viral infections, with activity on cells of epithelial origin and located in the mucosal surfaces.
Nancy Patricia Cardoso, Florencia Celeste Mansilla, Estefanía Benedetti, Cecilia Soledad Turco, Lucas José Barone, Javier Alonso Iserte, Ivana Soria, Elsa Baumeister, Alejandra Victoria Capozzo   +8 more
doaj   +1 more source

COL1A1+ Epithelial Cells Orchestrate VEGFA‐VEGFR Signaling in Endometritis Revealed by Single‐Cell Analysis

Journal of Clinical Laboratory Analysis, EarlyView.
Single‐cell RNA‐seq of normal and endometritis endometrium shows reduced epithelial cells and fate divergence toward ferroptosis or ribosome/antigen‐presentation programs. COL1A1+ epithelial cells act as an AP‐1–driven hub that enhances VEGFA–VEGFR signaling and remodels the vascular microenvironment.
Chengzi Tian, Zaiyi Li
wiley   +1 more source

Multiomics Insights Into AL Amyloidosis

Medicine Bulletin, EarlyView.
ABSTRACT Light chain amyloidosis is a systemic or localized protein conformational disorder triggered by misfolded immunoglobulin light chains, leading to amyloid fibril deposition. The disease is characterized by multiorgan involvement and delayed diagnosis, contributing to poor prognosis and high mortality rates.
Zixuan Zhang, Ziru Huang, Haoxiang Tang, Xianrun Pan, Rong Wang, Dingding Zhang, Jian Huang   +6 more
wiley   +1 more source

Fiber Bragg Grating Force Sensors for Minimally Invasive Surgery: State of the Art, Challenges, and Opportunities

SmartBot, EarlyView.
This article reviews the application of fiber Bragg grating (FBG) technology for precise force sensing in minimally invasive surgery. It outlines the fundamental working principles and algorithms used to interpret sensor data. The text surveys clinical applications across various medical fields, such as ophthalmology and vascular intervention (Table of
Shiyuan Dong, Tianqi Huang, Lingyu Chen, Shucong Yin, Qing Chang, Dingpei Han, Yangxi Li, Boyu Zhang, Hongen Liao, Fang Chen   +9 more
wiley   +1 more source

Endocytosis‐independent cytosolic entry of messenger RNA via fluorous bilayer zippering attenuating Toll‐like receptor signaling and enables ischemic tissue salvage

Smart Molecules, EarlyView.
The present study establishes a paradigm shift in synthetic mRNA delivery through the convergence of three orthogonal chemistries—perfluoro‐acylation, bio‐orthogonal click cross‐linking, and disulfide reduction—within a single, modular polymer architecture. Abstract A fundamental constraint of conventional messenger RNA (mRNA) delivery systems is their
Yue Wang, Haitao Xie, Guoqing Xiang, Yanhua Li, Changgui Tong, Hongyan Cui, Qixian Chen, Haidong Li, Yan Zhao   +8 more
wiley   +1 more source

Interferon (IFN)-λ Takes the Helm: Immunomodulatory Roles of Type III IFNs

Frontiers in Immunology, 2017
Type III interferons (IFNs) (or IFN-λ) are the latest addition to the IFN family. Even though they share little protein homology with type I IFN, both exhibit remarkable functional similarities: each can be induced in response to viral infections, and ...
Ivan Zanoni, Ivan Zanoni, Francesca Granucci, Achille Broggi   +3 more
doaj   +1 more source

Credit‐Driven Adaptive Grouping for Refined Cooperative Multi‐Agent Reinforcement Learning

CAAI Transactions on Intelligence Technology, EarlyView.
ABSTRACT Policy heterogeneity is crucial for achieving sophisticated coordination in complex collaborative tasks, which has emerged as one of the key challenges in multi‐agent reinforcement learning (MARL) in recent years. Notably, the grouping paradigm has made remarkable progress in addressing policy heterogeneity.
Yirui Liu, Xueqiang Gu, Caiming Zheng, Xin Xu, Zhangling Wang, Wanpeng Zhang, Yixing Lan   +6 more
wiley   +1 more source

Interferons and systemic sclerosis: correlation between interferon gamma and interferon-lambda 1 (IL-29)

Autoimmunity, 2015
Interferon (IFN)-λ1 is a newly described cytokine, member of type III interferons family, which is known for its antiviral, anti-proliferative and antitumor activity. Recent studies indicated that this cytokine has also immune-regulatory function, but its role in the pathogenesis of autoimmune diseases is not established yet.
Andréa Tavares, Dantas, Sayonara Maria Calado, Gonçalves, Michelly Cristiny, Pereira, Anderson Rodrigues, de Almeida, Cláudia Diniz Lopes, Marques, Moacyr Jesus Barreto de Melo, Rego, Ivan da Rocha, Pitta, Angela Luzia Branco Pinto, Duarte, Maira Galdino da Rocha, Pitta   +8 more
openaire   +2 more sources

TriCrackNet: Trilateral Segmentation Network for Real‐Time Crack Segmentation

CAAI Transactions on Intelligence Technology, EarlyView.
ABSTRACT To achieve high‐precision real‐time crack segmentation, we propose TriCrackNet, an efficient network based on a tri‐branch collaborative architecture incorporating boundary constraints, semantic parsing, and spatial refinement. In the semantic branch, efficient atrous spatial pyramid pooling (EASPP) is integrated.
Haixin Jia, Han Wang, Xiaoqiang Shi, Guoying Zhang, Hanqi Jiang, Jianbo Peng   +5 more
wiley   +1 more source

Cyberattack‐Resilient Fractional‐Order PPI Control for Frequency Regulation in PV‐Integrated Power Systems

CAAI Transactions on Intelligence Technology, EarlyView.
ABSTRACT Load‐frequency control (LFC) comprises a primary process in interconnected electrical power systems, playing a critical role in maintaining the stability and reliability of the electrical grid. It is of paramount importance that the designed controller functions in an optimal manner, particularly with regard to the compression of area ...
Bora Çavdar, Erdinç Şahin, Fatih Mehmet Nuroğlu   +2 more
wiley   +1 more source