Results 101 to 110 of about 260,978 (210)

Interferon (IFN)-λ Takes the Helm: Immunomodulatory Roles of Type III IFNs

Frontiers in Immunology, 2017
Type III interferons (IFNs) (or IFN-λ) are the latest addition to the IFN family. Even though they share little protein homology with type I IFN, both exhibit remarkable functional similarities: each can be induced in response to viral infections, and ...
Ivan Zanoni, Ivan Zanoni, Francesca Granucci, Achille Broggi   +3 more
doaj   +1 more source

Adaptive Immunity in Marsupials

Journal of Experimental Zoology Part A: Ecological and Integrative Physiology, EarlyView.
Comparison of the marsupial and eutherian adaptive immune systems. ABSTRACT Marsupials diverged from eutherian mammals 125–160 million years ago. Although evolutionarily distinct, both groups of mammals can produce complex adaptive immune responses to antigens with several key differences.
Cassandra L. Jol, Hayley J. Stannard, Julie M. Old   +2 more
wiley   +1 more source

Interferons and systemic sclerosis: correlation between interferon gamma and interferon-lambda 1 (IL-29)

Autoimmunity, 2015
Interferon (IFN)-λ1 is a newly described cytokine, member of type III interferons family, which is known for its antiviral, anti-proliferative and antitumor activity. Recent studies indicated that this cytokine has also immune-regulatory function, but its role in the pathogenesis of autoimmune diseases is not established yet.
Andréa Tavares, Dantas, Sayonara Maria Calado, Gonçalves, Michelly Cristiny, Pereira, Anderson Rodrigues, de Almeida, Cláudia Diniz Lopes, Marques, Moacyr Jesus Barreto de Melo, Rego, Ivan da Rocha, Pitta, Angela Luzia Branco Pinto, Duarte, Maira Galdino da Rocha, Pitta   +8 more
openaire   +2 more sources

Multiomics Insights Into AL Amyloidosis

Medicine Bulletin, EarlyView.
ABSTRACT Light chain amyloidosis is a systemic or localized protein conformational disorder triggered by misfolded immunoglobulin light chains, leading to amyloid fibril deposition. The disease is characterized by multiorgan involvement and delayed diagnosis, contributing to poor prognosis and high mortality rates.
Zixuan Zhang, Ziru Huang, Haoxiang Tang, Xianrun Pan, Rong Wang, Dingding Zhang, Jian Huang   +6 more
wiley   +1 more source

Dynamic early biomarkers predict outcomes in pediatric Epstein–Barr virus‐associated hemophagocytic lymphohistiocytosis

Pediatric Investigation, EarlyView.
This study elucidates the critical pathogenic mechanisms of pediatric Epstein–Barr virus‐associated hemophagocytic lymphohistiocytosis (EBV‐HLH), where EBV infection triggers a cytokine storm leading to immune cell hyperactivation and tissue damage. Dynamic plasma biomarkers (EBV‐DNA, ferritin, and interferon‐γ) effectively predict treatment response ...
Feifei Liu, Qing Zhang, Sitong Chen, Yunze Zhao, Dong Wang, Hongyun Lian, Honghao Ma, Tianyou Wang, Rui Zhang, Zhigang Li   +9 more
wiley   +1 more source

Human IFNAR2 deficiency : lessons for antiviral immunity [PDF]

, 2015
C.J.A.D. was supported by the Academy of Medical Sciences (AMS-SGCL11), the British Infection Association, and the UK NIH Research (NIHR); S.M.B.M. was supported by the Universiti Sains Malaysia Fellowship; K.R.E. and S.H. were supported by the Sir Jules
Cant, Andrew J., Skelton, Andrew J., Leahy, T. Ronan, Morfopoulou, Sofia, Mohamad, Siti M. B., Dempsey, Eugene, Lynch, Niamh E., McMahon, Cathy, Breuer, Judith, Hubank, Mike, Valappil, Manoj, Duncan, Christopher J. A., Connell, Jeff, Jacques, Thomas S., Engelhardt, Karin R., Hambleton, Sophie, Butler, Karina M., Randall, Richard Edward, Young, Dan Frushard, Munday, Diane Carolyn, Gavin, Patrick J., Brown, Julianne R.   +21 more
core   +1 more source

Fiber Bragg Grating Force Sensors for Minimally Invasive Surgery: State of the Art, Challenges, and Opportunities

SmartBot, EarlyView.
This article reviews the application of fiber Bragg grating (FBG) technology for precise force sensing in minimally invasive surgery. It outlines the fundamental working principles and algorithms used to interpret sensor data. The text surveys clinical applications across various medical fields, such as ophthalmology and vascular intervention (Table of
Shiyuan Dong, Tianqi Huang, Lingyu Chen, Shucong Yin, Qing Chang, Dingpei Han, Yangxi Li, Boyu Zhang, Hongen Liao, Fang Chen   +9 more
wiley   +1 more source

On equivalences and standardization in a non-deterministic call-by-need lambda calculus [PDF]

, 2007
The goal of this report is to prove correctness of a considerable subset of transformations w.r.t. contextual equivalence in a an extended lambda-calculus with case, constructors, seq, let, and choice, with a simple set of reduction rules. Unfortunately,
Mann, Matthias, Schmidt-Schauß, Manfred, Matthias Mann, Manfred Schmidt-schauß   +3 more
core  

Interferon Lambda-3 Polymorphism and Response to Pegylated Interferon in Patients with Hepatitis D

Antiviral Therapy, 2014
Background Specific single nucleotide polymorphisms (SNPs) near the interferon lambda-3 (IFNλ3) gene (formerly interleukin 28B) influence the response to treatment with interferon in hepatitis C patients. We aimed to investigate such an influence in hepatitis D patients.
Abbas, Zaigham, Yakoob, javed, Umer,, Muhammad A, Abbas, Minaam, Hamid, Saeed   +4 more
openaire   +3 more sources

Endocytosis‐independent cytosolic entry of messenger RNA via fluorous bilayer zippering attenuating Toll‐like receptor signaling and enables ischemic tissue salvage

Smart Molecules, EarlyView.
The present study establishes a paradigm shift in synthetic mRNA delivery through the convergence of three orthogonal chemistries—perfluoro‐acylation, bio‐orthogonal click cross‐linking, and disulfide reduction—within a single, modular polymer architecture. Abstract A fundamental constraint of conventional messenger RNA (mRNA) delivery systems is their
Yue Wang, Haitao Xie, Guoqing Xiang, Yanhua Li, Changgui Tong, Hongyan Cui, Qixian Chen, Haidong Li, Yan Zhao   +8 more
wiley   +1 more source