Results 1 to 10 of about 302,768 (263)
LINE-1 retrotransposon activation drives age-associated inflammation via cytoplasmic cDNA-STING/type I interferon signalling: therapeutic potential of reverse transcriptase inhibition [PDF]
Contemporary OncologyRetrotransposable elements are harmful at several levels, and host surveillance systems fail to consider all these elements in severe effects. The key role of retrotransposon in aging and age-associated diseases remains unclear. We summarise whether LINE-
Arshad Mehmood +5 more
doaj +2 more sources
Context-dependent impact of type I interferon signaling in cancer [PDF]
Molecular CancerType I interferon (IFN) has long been known as a critical component of the molecular machinery that first responds to viral infection in multicellular eukaryotes.
Ainhoa Ruiz-Iglesias +3 more
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Interferon Type I Regulates Inflammasome Activation and High Mobility Group Box 1 Translocation in Hepatocytes During Ehrlichia-Induced Acute Liver Injury. [PDF]
Hepatol Commun, 2021 Kader M +6 more
europepmc +3 more sources
Cloning of human Type I interferon cDNAs
Proceedings of the Japan Academy. Series B, Physical and Biological Sciences, 2023 In the late 1970s, crude interferon samples were found to exhibit anti-tumour activity. This discovery led to the interferon as a “magic drug” for cancer patients.
Shigekazu NAGATA
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Rotavirus NSP1 Inhibits Type I and Type III Interferon Induction
Viruses, 2021 Type I interferons (IFNs) are produced by most cells in response to virus infection and stimulate a program of anti-viral gene expression in neighboring cells to suppress virus replication. Type III IFNs have similar properties, however their effects are
Gennaro Iaconis +7 more
doaj +1 more source
Evasion of Type I Interferon by SARS-CoV-2
Cell Reports, 2020 Summary: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) replication and host immune response determine coronavirus disease 2019 (COVID-19), but studies evaluating viral evasion of immune response are lacking. Here, we use unbiased screening
Hongjie Xia +8 more
doaj +1 more source
Insights Into Type I and III Interferons in Asthma and Exacerbations
Frontiers in Immunology, 2020 Asthma is a highly prevalent, chronic respiratory disease that impacts millions of people worldwide and causes thousands of deaths every year.
Helen E. Rich +4 more
doaj +1 more source
Type I interferon: potential therapeutic target for psoriasis? [PDF]
PLoS ONE, 2008 BACKGROUND: Psoriasis is an immune-mediated disease characterized by aberrant epidermal differentiation, surface scale formation, and marked cutaneous inflammation.
Yihong Yao +10 more
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Biomolecules, 2021 There is a great deal of evidence pointing to interferons (IFNs) as being key cytokines in the pathogenesis of different systemic autoimmune diseases, including primary Sjögren’s syndrome (pSS).
Nicoletta Del Papa +8 more
doaj +1 more source
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2021 Background We previously demonstrated that ischemically injured cardiomyocytes release cell‐free DNA and HMGB1 (high mobility group box 1 protein) into circulation during reperfusion, activating proinflammatory responses and ultimately exacerbating ...
Lina Lai +5 more
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