Results 1 to 10 of about 306,829 (312)
LINE-1 retrotransposon activation drives age-associated inflammation via cytoplasmic cDNA-STING/type I interferon signalling: therapeutic potential of reverse transcriptase inhibition [PDF]
Contemporary OncologyRetrotransposable elements are harmful at several levels, and host surveillance systems fail to consider all these elements in severe effects. The key role of retrotransposon in aging and age-associated diseases remains unclear. We summarise whether LINE-
Arshad Mehmood +5 more
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Context-dependent impact of type I interferon signaling in cancer [PDF]
Molecular CancerType I interferon (IFN) has long been known as a critical component of the molecular machinery that first responds to viral infection in multicellular eukaryotes.
Ainhoa Ruiz-Iglesias +3 more
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Cloning of human Type I interferon cDNAs
Proceedings of the Japan Academy. Series B, Physical and Biological Sciences, 2023 In the late 1970s, crude interferon samples were found to exhibit anti-tumour activity. This discovery led to the interferon as a “magic drug” for cancer patients.
Shigekazu NAGATA
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Rotavirus NSP1 Inhibits Type I and Type III Interferon Induction
Viruses, 2021 Type I interferons (IFNs) are produced by most cells in response to virus infection and stimulate a program of anti-viral gene expression in neighboring cells to suppress virus replication. Type III IFNs have similar properties, however their effects are
Gennaro Iaconis +7 more
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Evasion of Type I Interferon by SARS-CoV-2
Cell Reports, 2020 Summary: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) replication and host immune response determine coronavirus disease 2019 (COVID-19), but studies evaluating viral evasion of immune response are lacking. Here, we use unbiased screening
Hongjie Xia +8 more
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Insights Into Type I and III Interferons in Asthma and Exacerbations
Frontiers in Immunology, 2020 Asthma is a highly prevalent, chronic respiratory disease that impacts millions of people worldwide and causes thousands of deaths every year.
Helen E. Rich +4 more
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Type I interferon: potential therapeutic target for psoriasis? [PDF]
PLoS ONE, 2008 BACKGROUND: Psoriasis is an immune-mediated disease characterized by aberrant epidermal differentiation, surface scale formation, and marked cutaneous inflammation.
Yihong Yao +10 more
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Biomolecules, 2021 There is a great deal of evidence pointing to interferons (IFNs) as being key cytokines in the pathogenesis of different systemic autoimmune diseases, including primary Sjögren’s syndrome (pSS).
Nicoletta Del Papa +8 more
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Antiproliferative Properties of Type I and Type II Interferon
Pharmaceuticals, 2010 The clinical possibilities of interferon (IFN) became apparent with early studies demonstrating that it was capable of inhibiting tumor cells in culture and in vivo using animal models.
Joseph Bekisz +4 more
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Journal of Experimental & Clinical Cancer Research, 2021 Background Improvement of radiotherapy efficacy requires better insight in the dynamic responses that occur during irradiation. Here, we aimed to identify the molecular responses that are triggered during clinically applied fractionated irradiation ...
Ruben S. A. Goedegebuure +15 more
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