Results 31 to 40 of about 2,200,720 (269)

Interleukin 31 in insect bite hypersensitivity-Alleviating clinical symptoms by active vaccination against itch. [PDF]

Allergy, 2020
Insect bite hypersensitivity (IBH) is the most common seasonal pruritic allergic dermatitis of horses occurring upon insect bites. In recent years, a major role for IL‐31 in allergic pruritus of humans, monkeys, dogs, and mice was acknowledged.
Olomski F, Fettelschoss V, Jonsdottir S, Birkmann K, Thoms F, Marti E, Bachmann MF, Kündig TM, Fettelschoss-Gabriel A.   +8 more
europepmc   +2 more sources

Interleukin-31, Interleukin-31RA, and OSMR Expression Levels in Post-burn Hypertrophic Scars [PDF]

Journal of Pathology and Translational Medicine, 2018
Background Although several studies have shown the role of interleukin-31 (IL-31) and its receptors in inducing pruritus in certain skin disorders, knowledge of its role in post-burn hypertrophic scars is insufficient.
Mi Young Lee, Eun Shin, Hyunchul Kim, In Suk Kwak, Younghee Choi   +4 more
doaj   +2 more sources

Involvement of Leukotriene B4 Released from Keratinocytes in Itch-associated Response to Intradermal Interleukin-31 in Mice

Acta Dermato-Venereologica, 2017
A recent study suggests that interleukin-31 (IL-31) exerts its effect via indirect mechanisms rather than through direct stimulation of cutaneous nerves.
Tsugunobu Andoh, Ayako Harada, Yasushi Kuraishi   +2 more
doaj   +2 more sources

Interleukin-31 in Respiratory Type 2 Inflammatory Diseases: Mechanistic Insights and Therapeutic Potential [PDF]

Journal of Inflammation Research
Shuang Yao,1,2,* Yan Zhao,1,2,* Zhimeng Li,3,4 Hongfei Lou,5,* Luo Zhang1,2,4,6,* 1Department of Otolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing, People’s Republic of ...
Yao S, Zhao Y, Li Z, Lou H, Zhang L
doaj   +2 more sources

Analyzing the Antinociceptive Effect of Interleukin-31 in Mice. [PDF]

Int J Mol Sci, 2023
The theory that an itch inhibits pain has been refuted; however, previous research did not investigate this theory for an interleukin-31 (IL-31)-induced itch. Previously, we have found that morphine-induced antinociception was partially reduced in IL-31 receptor A (IL-31RA)-deficient (IL-31RAKI) mice, indicating that IL-31RA may play an important role ...
Arai I, Tsuji M, Takahashi K, Saito S, Takeda H.   +4 more
europepmc   +4 more sources

Evaluation of Interleukin-31 Serum Levels in Patients with Chronic Kidney Disease on Hemodialysis with and without Uremic Pruritus [PDF]

مجلة كلية الطب
Background: Interleukin-31 has been linked with developing and maintaining pruritus in various dermatological and non-dermatological diseases. Objectives: To evaluate interleukin-31 serum levels in hemodialysis patients with and without uremic ...
Mustafa Sh. Abdulqahar, Ali A. Kasem
doaj   +3 more sources

The role of interleukin-31 in human allergic disease [PDF]

, 2013
The newly described cytokine Interleukin (IL) 31 has been shown to be expressed by murine activated T lymphocytes of a Th2 phenotype. Like IL-17 and IL-22, IL-31 is a tissue signalling cytokine whose receptor is mainly found on non-immune cells.
Stott, Bryony Alexandra
core   +4 more sources

Regulation of Th2 responses by different cell types expressing the interleukin-31 receptor [PDF]

Allergy, Asthma & Clinical Immunology, 2017
Background Interleukin-31 (IL-31) is a recently identified cytokine produced by Th2 cells that is involved in the development of atopic dermatitis-induced skin inflammation and pruritus.
Saburo Saito, Ayana Aoki, Iwao Arai, Shinya Takaishi, Haruyasu Ito, Nobutake Akiyama, Hiroshi Kiyonari   +6 more
doaj   +2 more sources

Anti–Interleukin‐31 Receptor A Antibody for Atopic Dermatitis

New England Journal of Medicine, 2017
Interleukin-31 may play a role in the pathobiologic mechanism of atopic dermatitis and pruritus. We wanted to assess the efficacy and safety of nemolizumab (CIM331), a humanized antibody against interleukin-31 receptor A, in the treatment of atopic dermatitis.In this phase 2, randomized, double-blind, placebo-controlled, 12-week trial, we assigned ...
T. Ruzicka, J. Hanifin, M. Furue, G. Pulka, I. Młynarczyk, A. Wollenberg, R. Galus, T. Etoh, R. Mihara, Hiroki Yoshida, J. Stewart, K. Kabashima   +11 more
semanticscholar   +9 more sources

Emerging role of interleukin‐31 and interleukin‐31 receptor in pruritus in atopic dermatitis [PDF]

Allergy, 2018
AbstractAtopic dermatitis (AD) is a chronic or chronically relapsing, eczematous, severely pruritic skin disorder associated with skin barrier dysfunction. The lesional skin of AD exhibits T helper 2 (TH2)‐deviated immune reactions. Interleukin‐31 (IL‐31), preferentially produced from TH2 cells, is a potent pruritogenic cytokine, and its systemic and ...
M. Furue, K. Yamamura, M. Kido-Nakahara, T. Nakahara, Yoshinori Fukui   +4 more
semanticscholar   +3 more sources