Results 31 to 40 of about 657,596 (286)

Impaired interferon-γ responses, increased interleukin-17 expression, and a tumor necrosis factor–α transcriptional program in invasive aspergillosis [PDF]

, 2009
This article is available open access through the publisher’s website. Copyright @ 2009 Oxford University Press.Background - Invasive aspergillosis (IA) is the most common cause of death associated with fungal infection in the developed world ...
Armstrong-James, DP, Bignell, E, Haynes, K, Rogers, NJ, Rogers, TRF, Stark, J, Teo, I, Turnbull, SA   +7 more
core   +1 more source

Pathogenic Effector Th2 Cells in Allergic Eosinophilic Inflammatory Disease

Frontiers in Medicine, 2017
There is an absolute requirement for Th2 cells in the pathogenesis of allergen-driven eosinophil-rich type 2 inflammation. Although Th2 cells are generally regarded as a homogeneous population, in the past decade there has been increasing evidence for a ...
Alyssa Mitson-Salazar, Calman Prussin
doaj   +1 more source

Reslizumab in patients with inadequately controlled late-onset asthma and elevated blood eosinophils [PDF]

, 2017
INTRODUCTION: Asthma with adult onset and elevated blood eosinophils is a difficult-to-treat subgroup. This post hoc analysis evaluated reslizumab, an anti-interleukin-5 monoclonal antibody, in patients with late-onset eosinophilic asthma.
Brusselle, Guy, Germinaro, Matthew, Weiss, Sivan, Zangrilli, James   +3 more
core   +2 more sources

Activation of the STAT3/Acute Phase Response Factor Transcription Factor by Interleukin-5 [PDF]

, 1995
The receptor for interleukin-5 (IL-5R) is composed of a unique a chain (IL-5Ra) expressed on eosinophils and basophils, associated with a bc subunit, which is shared by the receptors for IL-3 and granulocyte macrophagecolony stimulating factor.
Caldenhoven, Eric, Dijk, Thamar B. van, Groot, Rolf P. de, Koenderman, L., Lammers, J.W.J., Raaijmakers, J.A.M.   +5 more
core   +2 more sources

The intestinal expulsion of the roundworm Ascaris suum is associated with eosinophils, intra-epithelial T cells and decreased intestinal transit time [PDF]

, 2013
Ascaris lumbricoides remains the most common endoparasite in humans, yet there is still very little information available about the immunological principles of protection, especially those directed against larval stages.
A Fujiwara, A Roepstorff, A Zhao, A Zhao, Aaron R. Jex, BA Vallance, C Dold, C Moolenbeek, C Zhou, CD Criscione, CV Holland, D Leles, D Masure, Dries Masure, DW Crompton, F van Wijk, G Jungersen, GH Liu, HD Dawson, J Vandesompele, JF Urban Jr, Jimmy Saunders, Johnny Vlaminck, Jozef Vercruysse, KD Mccoy, Koen Chiers, L Eriksen, M Ashraf, M Morimoto, N Arizono, N Foster, N Miquel, NL Harris, P Kermanizadeh, P Nejsum, P O'Lorcain, PA Knight, Peter Geldhof, PI Uston, R Shamri, RM Anthony, RW Li, S Rozen, S Schmidt, Sarah Claerhoudt, Tao Wang, TB Stewart, TJ Anderson, Wim Van den Broeck   +48 more
core   +9 more sources

Eosinophils Are Important for Protection, Immunoregulation and Pathology during Infection with Nematode Microfilariae [PDF]

, 2014
Eosinophil responses typify both allergic and parasitic helminth disease. In helminthic disease, the role of eosinophils can be both protective in immune responses and destructive in pathological responses. To investigate whether eosinophils are involved
AA Humbles, AD Doyle, AD Klion, AE O'Connell, AM Galioto, Anita Y. N. Cheung, Ashleigh C. Johnston, BA Vallance, CA Gray, CA Gray, CS Enobe, D Abraham, D Voehringer, DR Herbert, E Pearlman, E Pinelli, EA Jacobsen, Emma T. Cadman, ET Cadman, H Kita, James J. Lee, JE Simons, JE Simons, JH Schroeder, JJ Lee, Katherine A. Thysse, KJ Hamann, KL Denzler, KL Denzler, L Le Goff, L O'Bryan, LA Spencer, LR Hall, M Lomask, M Witzenrath, ML Knott, PC Fulkerson, PL Milton, RA Lawrence, RA Lawrence, Rachel A. Lawrence, RK Mehlotra, S Pegorier, S Specht, SA Babayan, SI Ochkur, Siobhan Bearder, T Carter, T Ramalingam, T Ramalingam, Thomas B. Nutman, V Fabre, W Mitzner   +52 more
core   +4 more sources

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Immune Responses in Human Necatoriasis: Association between Interleukin-5 Responses and Resistance to Reinfection [PDF]

, 2004
Cytokine and proliferative responses to Necator americanus infection were measured in a treatment-reinfection study of infected subjects from an area of Papua New Guinea where N. americanus is highly endemic.
Brown, A.P., Pritchard, D.I., Quinnell, R.J., Raiko, A., Shaw, M.-A.   +4 more
core  

Healthcare resource use and costs of severe, uncontrolled eosinophilic asthma in the UK general population [PDF]

, 2017
Acknowledgments The authors thank Derek Skinner (Cambridge Research Support Ltd, Oakington, Cambridge, UK) for assistance with data extraction.Peer reviewedPublisher ...
Gibson, Danny, Golam, Sarowar, Hillyer, Elizabeth V, Kerkhof, Marjan, Price, David B, Soriano, Joan B, Tran, Trung N   +6 more
core   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source