Annals of Hepatology, 2016 Background and aims. Autoimmune hepatitis (AIH) is a chronic inflammatory condition of the liver in which the immunological mechanisms involved in tissue destruction and/or repair are still unclear. Different pro-inflammatory cytokines have been shown to
Pablo Thomas-Dupont +8 more
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Crohn's disease: Th1, Th17 or both? The change of a paradigm: new immunological and genetic insights implicate Th17 cells in the pathogenesis of Crohn's disease [PDF]
, 2009 Traditionally, Crohn's disease has been associated with a Th1 cytokine profile, while Th2 cytokines are modulators of ulcerative colitis. This concept has been challenged by the description of tolerising regulatory T cells (Treg) and by proinflammatory ...
Brand, Stephan
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Frontiers in Immunology, 2022 The new pandemic virus SARS-CoV-2 is characterized by uncontrolled hyper-inflammation in severe cases. As the IL-22/IL-22R1 axis was reported to be involved in inflammation during viral infections, we characterized the expression of IL-22 receptor1, IL ...
Nurhan Albayrak +12 more
doaj +1 more source
Interleukin-17 regulates matrix metalloproteinase activity in human pulmonary tuberculosis. [PDF]
, 2017 Tuberculosis (TB) is characterized by extensive pulmonary matrix breakdown. Interleukin-17 (IL-17) is key in host defence in TB but its role in TB-driven tissue damage is unknown.
Aggarwal +65 more
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Cytokines (interleukin-9, IL-17, IL-22, IL-25 and IL-33) and asthma
Advanced Biomedical Research, 2014 Asthma is a reversible airway obstruction that is characterized by constriction of airway smooth muscle, hyper secretion of mucus, edema and airway hyper responsiveness (AHR), mucus secretion and thickening of the basement membrane underlying the airway ...
Rahim Farahani +4 more
doaj +1 more source
Inhibitory role of trichostatin A in secretion function of mouse peripheral lymph node cells
Di-san junyi daxue xuebao, 2020 Objective To investigate the role of trichostatin A (TSA) and its mechanism on secretory function of peripheral lymph node cells in mice. Methods The adult male C57BL/6 mice were sacrificed and their peripheral lymph nodes (LN), mesenteric lymph nodes ...
LIU Yijia +8 more
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Systemic levels of IL-23 are strongly associated with disease activity in rheumatoid arthritis but not spondyloarthritis [PDF]
, 2009 Objectives Th17 cells are an effector T-cell population that plays a role in chronic inflammatory conditions and is dependent on IL-23 for their survival and expansion. More recently, a genetic association was discovered between polymorphisms in the gene
De Keyser, Filip +8 more
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Influence of oxidative stress, diaphragm fatigue, and inspiratory muscle training on the plasma cytokine response to maximum sustainable voluntary ventilation [PDF]
, 2014 The influence of oxidative stress, diaphragm fatigue, and inspiratory muscle training (IMT) on the cytokine response to maximum sustainable voluntary ventilation (MSVV) is unknown.
Brown PI +10 more
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Tristetraprolin regulation of interleukin-22 production [PDF]
Scientific Reports, 2015 AbstractInterleukin (IL)-22 is a STAT3-activating cytokine displaying characteristic AU-rich elements (ARE) in the 3′-untranslated region (3′-UTR) of its mRNA. This architecture suggests gene regulation by modulation of mRNA stability. Since related cytokines undergo post-transcriptional regulation by ARE-binding tristetraprolin (TTP), the role of this
Härdle, Lorena +8 more
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Role of Interleukin-22 in ulcerative colitis
Biomedicine & Pharmacotherapy, 2023 Ulcerative Colitis (UC) is a chronic disease, in the progression of which an immune overreaction may play an important role. IL-22 is a member of the IL-10 superfamily of cytokines and is pleiotropic in immune regulation and inflammatory responses. IL-22 can produce protective effects, promote wound healing and tissue regeneration, while it can also ...
Nan Zhao +6 more
openaire +2 more sources