Results 41 to 50 of about 848,154 (350)

The role of the novel Th17 cytokine IL-26 in intestinal inflammation [PDF]

, 2008
Background and aims: Interleukin 26 (IL-26), a novel IL-10-like cytokine without a murine homologue, is expressed in T helper 1 (Th1) and Th17 cells. Currently, its function in human disease is completely unknown. The aim of this study was to analyse its
Auernhammer, Christoph J., Beigel, Florian, Brand, Stephan, Dambacher, J., Diepolder, Helmut M., Göke, Burkhard, Toni, Enrico N. de, Zitzmann, K.   +7 more
core   +1 more source

Interleukin-22 acts as a mitochondrial protector

Theranostics, 2020
Interleukin (IL)-22 has been increasingly recognized as a promising therapeutic option for various types of diseases. This commentary summarizes the novel mechanistic aspects of IL-22 for the treatment of liver diseases including the study by Chen et al.
Hwang, Seonghwan, Feng, Dechun, Gao, Bin
openaire   +2 more sources

Role of Interleukin-22 in liver diseases [PDF]

Inflammation Research, 2014
Interleukin (IL)-22, originally referred to as IL-TIF for IL-10-related T cell-derived inducible factor, is a member of the IL-10-like cytokine family. IL-22 is highly expressed by Th17 cells and is tightly linked to chronic inflammation, including inflammatory bowel disease and local intestinal inflammation among others.A PubMed and Web of Science ...
Pan, Chun-xiao, Tang, Jie, Wang, Xiao-yu, Wu, Fan-rong, Ge, Jin-fang, Chen, Fei-hu   +5 more
openaire   +2 more sources

Expression of Interleukin‐22 in Myasthenia Gravis [PDF]

Scandinavian Journal of Immunology, 2013
AbstractIL‐17 and IL‐22 are implicated in the pathogenesis of autoimmune diseases. The roles of IL‐22 in the pathophysiology of myasthenia gravis (MG) remain unsettled. The aim of this study was to investigate the possible relationship between serum IL‐22, IL‐17 levels, anti‐acetylcholine receptor antibody (anti‐AChR Ab) titres and clinical parameters ...
S, Zheng, C, Dou, N, Xin, J, Wang, J, Wang, P, Li, L, Fu, X, Shen, G, Cui, R, Dong, J, Lu, Y, Zhang   +11 more
openaire   +2 more sources

Interleukin-1 blockade in recently decompensated systolic heart failure: study design of the recently decompensated heart failure anakinra response trial (RED-HART) [PDF]

, 2015
Heart Failure (HF) is a clinical syndrome characterized by dyspnea, fatigue, and poor exercise capacity due to impaired cardiac function. The incidence of HF is increasing and represents the leading cause of hospitalization in the United States among ...
Abbate Antonio, Abouzaki Nayef, Arena Ross, BIONDI ZOCCAI, GIUSEPPE, Canada Justin, CARBONE, SALVATORE, Oddi Erdle Claudia, Valle Raleigh Juan, Van Tassell Benjamin W   +8 more
core   +1 more source

Interleukin-22 Influences the Th1/Th17 Axis

Frontiers in Immunology, 2021
Interleukin-22 (IL-22) is secreted by a wide range of immune cells and its downstream effects are mediated by the IL-22 receptor, which is present on non-immune cells in many organs throughout the body.
Hannes Lindahl, Tomas Olsson
doaj   +1 more source

Lactobacillus delivery of bioactive interleukin-22 [PDF]

Microbial Cell Factories, 2017
Interleukin-22 (IL-22) plays a prominent role in epithelial regeneration and dampening of chronic inflammatory responses by protecting intestinal stem cells from immune-mediated tissue damage. IL-22 has a considerable therapeutic potential in graft-versus-host disease (GVHD), which is a frequent and challenging complication following allogeneic stem ...
Lin, Yin, Krogh-Andersen, Kasper, Hammarström, Lennart, Marcotte, Harold   +3 more
openaire   +2 more sources

Role of subclinical gut inflammation in the pathogenesis of spondyloarthritis [PDF]

, 2018
Subclinical gut inflammation occurring in patients affected by spondyloarthritis (SpA) is correlated with the severity of spine inflammation. Several evidences indicate that dysbiosis occurs in SpA, and that may modulate intestinal permeability and ...
Ciccia F., Ferrante A., Guggino G., Rizzo A.   +3 more
core   +1 more source

Interleukin-1 polymorphisms associated with increased risk of gastric cancer [PDF]

, 2000
Helicobacter pylori infection is associated with a variety of clinical outcomes including gastric cancer and duodenal ulcer disease. The reasons for this variation are not clear, but the gastric physiological response is influenced by the severity and ...
A Cox, B Ruiz, CA Dinarello, Charles S. Rabkin, Chiu-Chin Yuan, Correa, P., CR Yu, D Basso, DM Parkin, E El-Omar, E El-Omar, EJ Kuipers, EM El-Omar, Emad M. El-Omar, F Pociot, George Lanyon, HC Jung, Howard A. Young, HW Chow, IL Beales, Jay H. Bream, Jesus Herrera, JL Wallace, Jolanta Lissowska, Joseph F. Fraumeni, Kenneth E. L. McColl, LA Noach, LE Hansson, M Carrington, Mary Carrington, Maureen Martin, MJ Blaser, MM Wolfe, NA Tountas, Nathaniel Rothman, P Sipponen, RM Royall, RW Stockbruegger, S Santtila, T Andus, VA Danis, Wong-Ho Chow, Y Yamaoka   +42 more
core   +2 more sources

Interleukin-22 promotes tumor angiogenesis [PDF]

Angiogenesis, 2018
TH17 cells play important yet complex roles in cancer development and progression. We previously reported that TH17 cells and IL-17 mediate resistance to anti-VEGF therapy by inducing recruitment of immunosuppressive and proangiogenic myeloid cells to the tumor microenvironment. Here, we demonstrate that IL-22, a key effector cytokine expressed by TH17
Nicholas J. Protopsaltis, Wei Liang, Eric Nudleman, Napoleone Ferrara   +3 more
openaire   +4 more sources